Search Results - "Hartl, Frederike A."

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation by Swamy, Mahima, Beck-Garcia, Katharina, Beck-Garcia, Esmeralda, Hartl, Frederike A., Morath, Anna, Yousefi, O. Sascha, Dopfer, Elaine Pashupati, Molnár, Eszter, Schulze, Anna K., Blanco, Raquel, Borroto, Aldo, Martín-Blanco, Nadia, Alarcon, Balbino, Höfer, Thomas, Minguet, Susana, Schamel, Wolfgang W.A.

“…Signaling through the T cell receptor (TCR) controls adaptive immune responses. Antigen binding to TCRαβ transmits signals through the plasma membrane to…”
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Phospho-mimetic CD3ε variants prevent TCR and CAR signaling by Woessner, Nadine M, Brandl, Simon M, Hartmann, Sara, Schamel, Wolfgang W, Hartl, Frederike A, Minguet, Susana

“…Antigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3…”
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Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor by Juraske, Claudia, Wipa, Piyamaporn, Morath, Anna, Hidalgo, Jose Villacorta, Hartl, Frederike A, Raute, Katrin, Oberg, Hans-Heinrich, Wesch, Daniela, Fisch, Paul, Minguet, Susana, Pongcharoen, Sutatip, Schamel, Wolfgang W

“…T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are…”
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The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing by Dopfer, Elaine P., Hartl, Frederike A., Oberg, Hans-Heinrich, Siegers, Gabrielle M., Yousefi, O. Sascha, Kock, Sylvia, Fiala, Gina J., Garcillán, Beatriz, Sandstrom, Andrew, Alarcón, Balbino, Regueiro, Jose R., Kabelitz, Dieter, Adams, Erin J., Minguet, Susana, Wesch, Daniela, Fisch, Paul, Schamel, Wolfgang W.A.

“…Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3…”
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Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling by Hartl, Frederike A, Ngoenkam, Jatuporn, Beck-Garcia, Esmeralda, Cerqueira, Liz, Wipa, Piyamaporn, Paensuwan, Pussadee, Suriyaphol, Prapat, Mishra, Pankaj, Schraven, Burkhart, Günther, Stefan, Pongcharoen, Sutatip, Schamel, Wolfgang W A, Minguet, Susana

“…The T cell antigen receptor (TCR) is expressed on T cells, which orchestrate adaptive immune responses. It is composed of the ligand-binding clonotypic TCRαβ…”
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Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function by Hartl, Frederike A., Beck-Garcìa, Esmeralda, Woessner, Nadine M., Flachsmann, Lea J., Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M., Taromi, Sanaz, Fiala, Gina J., Morath, Anna, Mishra, Pankaj, Yousefi, O. Sascha, Zimmermann, Julia, Hoefflin, Nico, Köhn, Maja, Wöhrl, Birgitta M., Zeiser, Robert, Schweimer, Kristian, Günther, Stefan, Schamel, Wolfgang W., Minguet, Susana

“…Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the…”
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A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation by Lui, Victor G, Hoenig, Manfred, Cabrera-Martinez, Berenice, Baxter, Ryan M, Garcia-Perez, Josselyn E, Bailey, Olivia, Acharya, Atanu, Lundquist, Karl, Capera, Jesusa, Matusewicz, Paul, Hartl, Frederike A, D'Abramo, Marco, Alba, Josephine, Jacobsen, Eva-Maria, Niewolik, Doris, Lorenz, Myriam, Pannicke, Ulrich, Schulz, Ansgar S, Debatin, Klaus-Michael, Schamel, Wolfgang W, Minguet, Susana, Gumbart, James C, Dustin, Michael L, Cambier, John C, Schwarz, Klaus, Hsieh, Elena W Y

“…Lymphocyte-specific protein tyrosine kinase (LCK) is essential for T cell antigen receptor (TCR)-mediated signal transduction. Here, we report two siblings…”
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Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance by Minguet, Susana, Kläsener, Kathrin, Schaffer, Anna-Maria, Fiala, Gina J, Osteso-Ibánez, Teresa, Raute, Katrin, Navarro-Lérida, Inmaculada, Hartl, Frederike A, Seidl, Maximilian, Reth, Michael, Del Pozo, Miguel A

“…Immature B cells are subject to tolerance mechanisms that prevent the expression of self-reactive BCRs. Minguet and colleagues identify the membrane protein…”
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Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells by Schönle, Anne, Hartl, Frederike A., Mentzel, Jan, Nöltner, Theresa, Rauch, Katharina S., Prestipino, Alessandro, Wohlfeil, Sebastian A., Apostolova, Petya, Hechinger, Anne-Kathrin, Melchinger, Wolfgang, Fehrenbach, Kerstin, Guadamillas, Marta C., Follo, Marie, Prinz, Gabriele, Ruess, Ann-Katrin, Pfeifer, Dietmar, Angel del Pozo, Miguel, Schmitt-Graeff, Annette, Duyster, Justus, Hippen, Keli I., Blazar, Bruce R., Schachtrup, Kristina, Minguet, Susana, Zeiser, Robert

“…Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold protein that regulates signaling in multiple cell types. We found increased…”
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Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning by Paensuwan, Pussadee, Hartl, Frederike A, Yousefi, O Sascha, Ngoenkam, Jatuporn, Wipa, Piyamaporn, Beck-Garcia, Esmeralda, Dopfer, Elaine P, Khamsri, Boonruang, Sanguansermsri, Donruedee, Minguet, Susana, Schamel, Wolfgang W, Pongcharoen, Sutatip

“…Ligand binding to the TCR causes a conformational change at the CD3 subunits to expose the CD3ε cytoplasmic proline-rich sequence (PRS). It was suggested that…”
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Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function by Hartl, Frederike A., Beck-Garcìa, Esmeralda, Woessner, Nadine M., Flachsmann, Lea J., Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M., Taromi, Sanaz, Fiala, Gina J., Morath, Anna, Mishra, Pankaj, Yousefi, O. Sascha, Zimmermann, Julia, Hoefflin, Nico, Köhn, Maja, Wöhrl, Birgitta M., Zeiser, Robert, Schweimer, Kristian, Günther, Stefan, Schamel, Wolfgang W., Minguet, Susana

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The CD3 Conformational Change in the gamma delta T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing by Dopfer, Elaine P, Hartl, Frederike A, Oberg, Hans-Heinrich, Siegers, Gabrielle M, Yousefi, OSascha, Kock, Sylvia, Fiala, Gina J, Garcillan, Beatriz, Sandstrom, Andrew, Alarcon, Balbino, Regueiro, Jose R, Kabelitz, Dieter, Adams, Erin J, Minguet, Susana, Wesch, Daniela, Fisch, Paul, Schamel, Wolfgang WA

“…Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the alpha beta TCR, antigen induces a conformational change at the…”
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Correction: Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning by Paensuwan, Pussadee, Hartl, Frederike A, Yousefi, O Sascha, Ngoenkam, Jatuporn, Wipa, Piyamaporn, Beck-Garcia, Esmeralda, Dopfer, Elaine P, Khamsri, Boonruang, Sanguansermsri, Donruedee, Minguet, Susana, Schamel, Wolfgang W, Pongcharoen, Sutatip

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Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms by Prestipino, Alessandro, Emhardt, Alica J, Aumann, Konrad, O'Sullivan, David, Gorantla, Sivahari P, Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S, Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian, Ehl, Stephan, Hartl, Frederike A, Minguet, Susana, Miething, Cornelius, Heidel, Florian H, Kröger, Nicolaus, Triviai, Ioanna, Brummer, Tilman, Finke, Jürgen, Illert, Anna L, Ruggiero, Eliana, Bonini, Chiara, Duyster, Justus, Pahl, Heike L, Lane, Steven W, Hill, Geoffrey R, Blazar, Bruce R, von Bubnoff, Nikolas, Pearce, Erika L, Zeiser, Robert

“…Recent evidence has revealed that oncogenic mutations may confer immune escape. A better understanding of how an oncogenic mutation affects immunosuppressive…”
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Author Correction: Noncanonical binding of Lck to CD3[epsilon] promotes TCR signaling and CAR function by Hartl, Frederike A, Beck-Garcìa, Esmeralda, Woessner, Nadine M, Flachsmann, Lea J, Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M, Taromi, Sanaz

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Noncanonical binding of Lck to CD3[epsilon] promotes TCR signaling and CAR function by Hartl, Frederike A, Beck-Garcìa, Esmeralda, Woessner, Nadine M, Flachsmann, Lea J, Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M, Taromi, Sanaz

“…Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the…”
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Caveolin-1-dependent BCR nanoscale organization regulates B cell tolerance by Minguet, Susana, Kläsener, Kathrin, Schaffer, Anna-Maria, Fiala, Gina J., Osteso-Ibánez, Teresa, Raute, Katrin, Navarro-Lérida, Inmaculada, Hartl, Frederike A., Seidl, Maximilian, Reth, Michael, Del Pozo, Miguel A.

“…Caveolin-1 (Cav1) regulates plasma membrane nano-organization and compartmentalization. Here, we demonstrate that Cav1 controlled the distribution of…”
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