Search Results - "Hartl, D. L"

Mitochondrial pseudogenes: evolution's misplaced witnesses by Bensasson, Douda, Zhang, De-Xing, Hartl, Daniel L., Hewitt, Godfrey M.

“…Nuclear copies of mitochondrial DNA (mtDNA) have contaminated PCR-based mitochondrial studies of over 64 different animal species. Since the last review of…”
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High rate of DNA loss in the Drosophila melanogaster and Drosophila virilis species groups by Petrov, D A, Hartl, D L

“…We recently proposed that patterns of evolution of non-LTR retrotransposable elements can be used to study patterns of spontaneous mutation. Transposition of…”
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Population genetics of polymorphism and divergence by Sawyer, S.A. (Washington University, St. Louis, MO), Hartl, D.L

“…Frequencies of mutant sites are modeled as a Poisson random field in two species that share a sufficiently recent common ancestor. The selective effect of the…”
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Genetic Applications of an Inverse Polymerase Chain Reaction by Ochman, H, Gerber, A. S, Hartl, D. L

“…A method is presented for the rapid in vitro amplification of DNA sequences that flank a region of known sequence. The method uses the polymerase chain…”
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Evidence for DNA Loss as a Determinant of Genome Size by Petrov, Dmitri A., Sangster, Todd A., Johnston, J. Spencer, Hartl, Daniel L., Shaw, Kerry L.

“…Eukaryotic genome sizes range over five orders of magnitude. This variation cannot be explained by differences in organismic complexity (the C value paradox)…”
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Selection Intensity for Codon Bias by Hartl, D. L, Moriyama, E. N, Sawyer, S. A

“…The patterns of nonrandom usage of synonymous codons (codon bias) in enteric bacteria were analyzed. Poisson random field (PRF) theory was used to derive the…”
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Autoregulation of mariner transposase activity by overproduction and dominant-negative complementation by Lohe, A R, Hartl, D L

“…Genetic studies of the mariner transposable element Mos1 have revealed two novel types of regulatory mechanisms. In one mechanism, overproduction of the…”
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Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements by Lohe, A R, Moriyama, E N, Lidholm, D A, Hartl, D L

“…Horizontal transmission has been well documented as a major mechanism for the dissemination of mariner-like elements (MLEs) among species. Less well understood…”
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Transgene coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila by Siegal, M.L, Hartl, D.L

“…Studies of gene function and regulation in transgenic Drosophila are often compromised by the possibility of genomic position effects on gene expression. We…”
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Selective sweep of a newly evolved sperm-specific gene in Drosophila by Nurminsky, D.I, Nurminskaya, M.V, De Aguiar, D, Hartl, D.L

“…The pattern of genetic variation across the genome of Drosophila melanogaster is consistent with the occurrence of frequent 'selective sweeps', in which new…”
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High intrinsic rate of DNA loss in Drosophila by Petrov, Dmitri A, Lozovskaya, Elena R, Hartl, Daniel L

“…Pseudogenes are common in mammals but virtually absent in Drosophila. All putative Drosophila pseudogenes show patterns of molecular evolution that are…”
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Recent Origin of Plasmodium falciparum from a Single Progenitor by Volkman, Sarah K., Barry, Alyssa E., Lyons, Emily J., Nielsen, Kaare M., Thomas, Susan M., Choi, Mehee, Thakore, Seema S., Day, Karen P., Wirth, Dyann F., Hartl, Daniel L.

“…Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts efforts to control disease caused by this parasite. Genetic…”
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Genome clashes in hybrids: insights from gene expression by Landry, C R, Hartl, D L, Ranz, J M

“…In interspecific hybrids, novel phenotypes often emerge from the interaction of two divergent genomes. Interactions between the two transcriptional networks…”
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Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans by Branco, A T, Tao, Y, Hartl, D L, Lemos, B

“…X-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked…”
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Compensatory mutations restore fitness during the evolution of dihydrofolate reductase by Brown, Kyle M, Costanzo, Marna S, Xu, Wenxin, Roy, Scott, Lozovsky, Elena R, Hartl, Daniel L

“…Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. Although traditional viewpoints have assumed that…”
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Codon usage bias and base composition of nuclear genes in Drosophila by Moriyama, E.N, Hartl, D.L

“…The nuclear genes of Drosophila evolve at various rates. This variation seems to correlate with codon-usage bias. In order to elucidate the determining factors…”
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Mosaic Structure of Plasmids From Natural Populations of Escherichia coli by Boyd, E. F, Hill, C. W, Rich, S. M, Hartl, D. L

“…The distribution of plasmids related to the fertility factor F was examined in the ECOR reference collection of Escherichia coli. Probes specific for four…”
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A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents by Bustamante, Carlos D, Nielsen, Rasmus, Hartl, Daniel L

“…We present a new likelihood method for detecting constrained evolution at synonymous sites and other forms of nonneutral evolution in putative pseudogenes. The…”
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Effects of X-Linkage and Sex-Biased Gene Expression on the Rate of Adaptive Protein Evolution in Drosophila by Baines, John F., Sawyer, Stanley A., Hartl, Daniel L., Parsch, John

“…Patterns of polymorphism and divergence in Drosophila protein-coding genes suggest that a considerable fraction of amino acid differences between species can…”
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The Transposable Element mariner Mediates Germline Transformation in Drosophila melanogaster by Lidholm, D. A, Lohe, A. R, Hartl, D. L

“…A vector for germline transformation in Drosophila melanogaster was constructed using the transposable element mariner. The vector, denoted pMlwB, contains a…”
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