Search Results - "Hartl, Brian G"

Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors by Kraker, Alan J, Hartl, Brian G, Amar, Aneesa M, Barvian, Mark R, Showalter, H.D.Hollis, Moore, Charles W

“…Increased expression or activity of c-Src tyrosine kinase has been associated with the transformed phenotype in tumor cells and with progression of neoplastic…”
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Modulation of Histone Acetylation by [4-(Acetylamino)-N-(2-Amino-phenyl) Benzamide] in HCT-8 Colon Carcinoma by Kraker, Alan J, Mizzen, Craig A, Hartl, Brian G, Miin, Johnson, Allis, C David, Merriman, Ronald L

“…CI-994 or N -acetyldinaline [4-(acetylamino)- N -(2-amino-phenyl) benzamide] is an antitumor cytostatic agent currently undergoing clinical trial. Although…”
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Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor by Palmer, Brian D, Kraker, Alan J, Hartl, Brian G, Panopoulos, Athanasia D, Panek, Robert L, Batley, Brian L, Lu, Gina H, Trumpp-Kallmeyer, Susanne, Showalter, H. D. Hollis, Denny, William A

“…Following an earlier discovery of 1-phenylbenzimidazoles as ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR), further…”
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity by Klutchko, Sylvester R, Hamby, James M, Boschelli, Diane H, Wu, Zhipei, Kraker, Alan J, Amar, Aneesa M, Hartl, Brian G, Shen, Cynthia, Klohs, Wayne D, Steinkampf, Randall W, Driscoll, Denise L, Nelson, James M, Elliott, William L, Roberts, Billy J, Stoner, Chad L, Vincent, Patrick W, Dykes, Donald J, Panek, Robert L, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Hallak, Hussein, Bradford, Laura A, Showalter, H. D. Hollis, Doherty, Annette M

“…While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2,3-d]pyrimidin-7(8H)-ones as a…”
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors by Boschelli, Diane H, Wu, Zhipei, Klutchko, Sylvester R, Showalter, H. D. Hollis, Hamby, James M, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Batley, Brian, Panek, Robert L, Keiser, Joan, Hartl, Brian G, Kraker, Alan J, Klohs, Wayne D, Roberts, Bill J, Patmore, Sandra, Elliott, William L, Steinkampf, Randy, Bradford, Laura A, Hallak, Hussein, Doherty, Annette M

“…Screening of a compound library led to the identification of 2-amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the…”
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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase by Thompson, Andrew M, Connolly, Cleo J. C, Hamby, James M, Boushelle, Stacey, Hartl, Brian G, Amar, Aneesa M, Kraker, Alan J, Driscoll, Denise L, Steinkampf, Randall W, Patmore, Sandra J, Vincent, Patrick W, Roberts, Bill J, Elliott, William L, Klohs, Wayne, Leopold, Wilbur R, Showalter, H. D. Hollis, Denny, William A

“…A series of 3-aryl-1,6-naphthyridine-2,7-diamines and related 2-ureas were prepared and evaluated as inhibitors of the FGF receptor-1 tyrosine kinase…”
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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60 c -src by Thompson, Andrew M, Rewcastle, Gordon W, Boushelle, Stacey L, Hartl, Brian G, Kraker, Alan J, Lu, Gina H, Batley, Brian L, Panek, Robert L, Showalter, H. D. Hollis, Denny, William A

“…7-Substituted 3-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones are potent inhibitors of protein tyrosine kinases, with some selectivity for c-Src. The…”
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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60c-src by THOMPSON, Andrew M., REWCASTLE, Gordon W., BOUSHELLE, Stacey L., HARTL, Brian G., KRAKER, Alan J., LU, Gina H., BATLEY, Brian L., PANEK, Robert L., SHOWALTER, H. D. Hollis, DENNY, William A.

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors by Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L., Keiser, Joan, Hartl, Brian G., Kraker, Alan J., Klohs, Wayne D., Roberts, Bill J., Patmore, Sandra, Elliott, William L., Steinkampf, Randy, Bradford, Laura A., Hallak, Hussein, Doherty, Annette M.

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