Search Results - "Hartig, Roland"

Helicobacter exploits integrin for type IV secretion and kinase activation by Urman, Sylwia, Hartig, Roland, Misselwitz, Rolf, Sewald, Norbert, König, Wolfgang, Kwok, Terry, Berger, Jürgen, Rohde, Manfred, Backert, Steffen, Wessler, Silja, Zabler, Dana

“…Integrins are important mammalian receptors involved in normal cellular functions as well as pathogenesis of chronic inflammation and cancer. We propose that…”
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Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro by Mirdamadi, Yasaman, Thielitz, Anja, Wiede, Antje, Goihl, Alexander, Papakonstantinou, Eleni, Hartig, Roland, Zouboulis, Christos C., Reinhold, Dirk, Simeoni, Luca, Bommhardt, Ursula, Quist, Sven, Gollnick, Harald

“…A recent hypothesis suggests that a high glycaemic load diet-associated increase of insulin-like growth factor-1 (IGF-1) and insulin may promote acne by…”
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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience by Raza, Syed Ahsan, Albrecht, Anne, Çalışkan, Gürsel, Müller, Bettina, Demiray, Yunus Emre, Ludewig, Susann, Meis, Susanne, Faber, Nicolai, Hartig, Roland, Schraven, Burkhart, Lessmann, Volkmar, Schwegler, Herbert, Stork, Oliver

“…Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an…”
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NF-κB Activation and Potentiation of Proinflammatory Responses by the Helicobacter pylori CagA Protein by Brandt, Sabine, Kwok, Terry, Hartig, Roland, König, Wolfgang, Backert, Steffen, Falkow, Stanley

“…The Helicobacter pylori immunodominant protein, CagA, is associated with severe gastritis and carcinoma. Injection of CagA into gastric epithelial cells by…”
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Cutting Edge: IL-10-Producing Regulatory B Cells in Early Human Pregnancy by Rolle, Luise, Memarzadeh Tehran, Maryam, Morell-García, Anselm, Raeva, Yanitsa, Schumacher, Anne, Hartig, Roland, Costa, Serban-Dan, Jensen, Federico, Zenclussen, Ana Claudia

“…Problem The function of IL‐10 producing regulatory B cells (Breg) during gestation is unknown. Here, we aimed to understand their participation in early…”
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Activation of Abl by Helicobacter pylori : A Novel Kinase for CagA and Crucial Mediator of Host Cell Scattering by Tammer, Ina, Brandt, Sabine, Hartig, Roland, König, Wolfgang, Backert, Steffen

“…Background & Aims: The pathogenesis of Helicobacter pylori ( Hp )-associated diseases depends on a specialized type IV secretion system. This type IV secretion…”
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Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling by Kespohl, Birte, Hartig, Roland, Garbers, Yvonne, Lokau, Juliane, Garbers, Christoph

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Y192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection by Kästle, Matthias, Merten, Camilla, Hartig, Roland, Plaza-Sirvent, Carlos, Schmitz, Ingo, Bommhardt, Ursula, Schraven, Burkhart, Simeoni, Luca

“…Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its…”
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The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans by Ahmad, Ilyas, Lokau, Juliane, Kespohl, Birte, Malik, Naveed Altaf, Baig, Shahid Mahmood, Hartig, Roland, Behme, Daniel, Schwab, Roland, Altmüller, Janine, Jameel, Muhammad, Mucha, Sören, Thiele, Holger, Tariq, Muhammad, Nürnberg, Peter, Erdmann, Jeanette, Garbers, Christoph

“…Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features…”
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Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori by Tegtmeyer, Nicole, Wittelsberger, Ruth, Hartig, Roland, Wessler, Silja, Martinez-Quiles, Narcisa, Backert, Steffen

“…Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein…”
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Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells by ZHAO, LU, ZHAO, YUE, SCHWARZ, BETTINA, MYSLIWIETZ, JOSEF, HARTIG, ROLAND, CAMAJ, PETER, BAO, QI, JAUCH, KARL-WALTER, GUBA, MAKUS, ELLWART, JOACHIM WALTER, NELSON, PETER JON, BRUNS, CHRISTIANE JOSEPHINE

“…Tumor side population (SP) cells display stem-like properties that can be modulated by treatment with the calcium channel blocker verapamil. Verapamil can…”
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DNA double-strand breaks and micronuclei in human blood lymphocytes after repeated whole body exposures to 7T Magnetic Resonance Imaging by Fatahi, Mahsa, Reddig, Annika, Vijayalaxmi, Friebe, Björn, Hartig, Roland, Prihoda, Thomas J., Ricke, Jens, Roggenbuck, Dirk, Reinhold, Dirk, Speck, Oliver

“…To examine the extent of genetic damage, assessed from deoxyribonucleic acid (DNA) double-strand breaks (DSBs) and micronuclei (MN) in peripheral blood…”
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Sunitinib targets PDGF-receptor and Flt3 and reduces survival and migration of human meningioma cells by Andrae, Nadine, Kirches, Elmar, Hartig, Roland, Haase, Daniela, Keilhoff, Gerburg, Kalinski, Thomas, Mawrin, Christian

“…Abstract The multitargeted tyrosine-kinase inhibitor sunitinib is a highly effective anti-angiogenic and cytostatic agent in the therapy of various tumours…”
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G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells by Vo, Diep-Khanh Ho, Hartig, Roland, Weinert, Sönke, Haybaeck, Johannes, Nass, Norbert

“…The G-protein-coupled estrogen receptor (GPER) mediates rapid non-genomic effects of estrogen. Although GPER is able to induce proliferation, it is…”
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Analysis of DNA Double-Strand Breaks and Cytotoxicity after 7 Tesla Magnetic Resonance Imaging of Isolated Human Lymphocytes by Reddig, Annika, Fatahi, Mahsa, Friebe, Björn, Guttek, Karina, Hartig, Roland, Godenschweger, Frank, Roggenbuck, Dirk, Ricke, Jens, Reinhold, Dirk, Speck, Oliver

“…The global use of magnetic resonance imaging (MRI) is constantly growing and the field strengths increasing. Yet, only little data about harmful biological…”
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A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation by Tegtmeyer, Nicole, Hartig, Roland, Delahay, Robin M., Rohde, Manfred, Brandt, Sabine, Conradi, Jens, Takahashi, Seiichiro, Smolka, Adam J., Sewald, Norbert, Backert, Steffen

“…Fibronectin, a 250-kDa eukaryotic extracellular matrix protein containing an RGD motif plays crucial roles in cell-cell communication, development, tissue…”
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Regulatory B Cells Are Decreased and Impaired in Their Function in Peripheral Maternal Blood in Pre-term Birth by Busse, Mandy, Campe, Kim-Norina Jutta, Redlich, Anke, Oettel, Anika, Hartig, Roland, Costa, Serban-Dan, Zenclussen, Ana Claudia

“…Preterm birth (PTB) is defined as birth before 37 completed weeks of gestation. The causes of PTB are multiple and complex, the underlying pathophysiology…”
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Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18 by Dubiel, Dawadschargal, Wang, Jing, Hartig, Roland, Chaithongyot, Supattra, Dubiel, Wolfgang, Naumann, Michael

“…The COP9 signalosome (CSN) and cullin-RING ubiquitin ligases (CRLs) form latent CSN-CRL complexes detectable in cells. We demonstrate that the CSN variants…”
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Dementia-associated changes of immune cell composition within the cerebrospinal fluid by Busse, Stefan, Hoffmann, Jessica, Michler, Enrico, Hartig, Roland, Frodl, Thomas, Busse, Mandy

“…Inflammation and alterations in essential protein structures in the brain might also change the cellular distribution in the cerebrospinal fluid (CSF). Using…”
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Physiological Concentration of Exogenous Lactate Reduces Antimycin A Triggered Oxidative Stress in Intestinal Epithelial Cell Line IPEC-1 and IPEC-J2 In Vitro by Kahlert, Stefan, Junnikkala, Sami, Renner, Lydia, Hynönen, Ulla, Hartig, Roland, Nossol, Constanze, Barta-Böszörményi, Anikó, Dänicke, Sven, Souffrant, Wolfgang-Bernhard, Palva, Airi, Rothkötter, Hermann-Josef, Kluess, Jeannette

“…Weaning triggers an adaptation of the gut function including luminal lactate generation by lactobacilli, depending on gastrointestinal site. We hypothesized…”
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