Search Results - "Hartig, Phillip"

Occurrence and In Vitro Bioactivity of Estrogen, Androgen, and Glucocorticoid Compounds in a Nationwide Screen of United States Stream Waters by Conley, Justin M, Evans, Nicola, Cardon, Mary C, Rosenblum, Laura, Iwanowicz, Luke R, Hartig, Phillip C, Schenck, Kathleen M, Bradley, Paul M, Wilson, Vickie S

“…In vitro bioassays are sensitive, effect-based tools used to quantitatively screen for chemicals with nuclear receptor activity in environmental samples. We…”
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Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats by Conley, Justin M, Lambright, Christy S, Evans, Nicola, Strynar, Mark J, McCord, James, McIntyre, Barry S, Travlos, Gregory S, Cardon, Mary C, Medlock-Kakaley, Elizabeth, Hartig, Phillip C, Wilson, Vickie S, Gray, Jr, L Earl

“…Hexafluoropropylene oxide dimer acid [(HFPO-DA), GenX] is a member of the per- and polyfluoroalkyl substances (PFAS) chemical class, and elevated levels of…”
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Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity by Hornung, Michael W, Korte, Joseph J, Olker, Jennifer H, Denny, Jeffrey S, Knutsen, Carsten, Hartig, Phillip C, Cardon, Mary C, Degitz, Sigmund J

“…Abstract Thyroid hormone (TH) homeostasis is dependent upon coordination of multiple key events including iodide uptake, hormone synthesis, metabolism, and…”
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Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases by Olker, Jennifer H, Korte, Joseph J, Denny, Jeffrey S, Hartig, Phillip C, Cardon, Mary C, Knutsen, Carsten N, Kent, Paige M, Christensen, Jessica P, Degitz, Sigmund J, Hornung, Michael W

“…Abstract Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine…”
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Fifteen Years after “Wingspread”—Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go by Hotchkiss, Andrew K., Rider, Cynthia V., Blystone, Chad R., Wilson, Vickie S., Hartig, Phillip C., Ankley, Gerald T., Foster, Paul M., Gray, Clark L., Gray, L. Earl

“…In 1991, a group of expert scientists at a Wingspread work session on endocrine-disrupting chemicals (EDCs) concluded that “Many compounds introduced into the…”
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In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays by Degitz, Sigmund J, Olker, Jennifer H, Denny, Jeffery S, Degoey, Philip P, Hartig, Phillip C, Cardon, Mary C, Eytcheson, Stephanie A, Haselman, Jonathan T, Mayasich, Sally A, Hornung, Michael W

“…The US Environmental Protection Agency is evaluating the ecological and toxicological effects of per- and polyfluorinated chemicals. A number of perfluorinated…”
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In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase by Olker, Jennifer H., Korte, Joseph J., Denny, Jeffrey S., Haselman, Jonathan T., Hartig, Phillip C., Cardon, Mary C., Hornung, Michael W., Degitz, Sigmund J.

“…The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially…”
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De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection by Medlock Kakaley, Elizabeth K., Blackwell, Brett R., Cardon, Mary C., Conley, Justin M., Evans, Nicola, Feifarek, David J., Furlong, Edward T., Glassmeyer, Susan T., Gray, L. Earl, Hartig, Phillip C., Kolpin, Dana W., Mills, Marc A., Rosenblum, Laura, Villeneuve, Daniel L., Wilson, Vickie S.

“…[Display omitted] •A suite of in vitro assays was applied to detect biological activity.•Estrogenic and glucocorticoid activity in effluent was corroborated by…”
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Generalized Concentration Addition Model Predicts Glucocorticoid Activity Bioassay Responses to Environmentally Detected Receptor-Ligand Mixtures by Medlock Kakaley, Elizabeth, Cardon, Mary C, Gray, L Earl, Hartig, Phillip C, Wilson, Vickie S

“…Abstract Many glucocorticoid receptor (GR) agonists have been detected in waste and surface waters domestically and around the world, but the way a mixture of…”
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Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals by Mayasich, Sally A., Korte, Joseph J., Denny, Jeffrey S., Hartig, Phillip C., Olker, Jennifer H., DeGoey, Philip, O’Flanagan, Joseph, Degitz, Sigmund J., Hornung, Michael W.

“…Deiodinase enzymes are critical for tissue-specific and temporal control of activation or inactivation of thyroid hormones during vertebrate development,…”
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Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA by Bradley, Paul M., Padilla, Ingrid Y., Romanok, Kristin M., Smalling, Kelly L., Focazio, Michael J., Breitmeyer, Sara E., Cardon, Mary C., Conley, Justin M., Evans, Nicola, Givens, Carrie E., Gray, James L., Gray, L. Earl, Hartig, Phillip C., Higgins, Christopher P., Hladik, Michelle L., Iwanowicz, Luke R., Lane, Rachael F., Loftin, Keith A., McCleskey, R. Blaine, McDonough, Carrie A., Medlock-Kakaley, Elizabeth, Meppelink, Shannon, Weis, Christopher P., Wilson, Vickie S.

“…A pilot-scale expanded target assessment of mixtures of inorganic and organic contaminants in point-of-consumption drinking water (tapwater, TW) was conducted…”
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In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters by Medlock Kakaley, Elizabeth, Cardon, Mary C., Evans, Nicola, Iwanowicz, Luke R., Allen, Joshua M., Wagner, Elizabeth, Bokenkamp, Katherine, Richardson, Susan D., Plewa, Michael J., Bradley, Paul M., Romanok, Kristin M., Kolpin, Dana W., Conley, Justin M., Gray, L. Earl, Hartig, Phillip C., Wilson, Vickie S.

“…Recent urban public water supply contamination events emphasize the importance of screening treated drinking water quality after distribution. In vitro…”
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A Conflicted Tale of Two Novel AR Antagonists In Vitro and In Vivo: Pyrifluquinazon Versus Bisphenol C by Gray, Leon Earl, Furr, Johnathan R, Conley, Justin M, Lambright, Christy S, Evans, Nicola, Cardon, Mary C, Wilson, Vickie S, Foster, Paul M, Hartig, Phillip C

“…Abstract Chemicals that disrupt androgen receptor (AR) function in utero induce a cascade of adverse effects in male rats including reduced anogenital…”
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Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot by Durhan, Elizabeth J, Lambright, Christy S, Makynen, Elizabeth A, Lazorchak, James, Hartig, Phillip C, Wilson, Vickie S, Gray, L Earl, Ankley, Gerald T

“…Little is known concerning the potential ecological effects of hormonally active substances associated with discharges from animal feeding operations…”
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Quantification of the Uncertainties in Extrapolating From In Vitro Androgen Receptor Antagonism to In Vivo Hershberger Assay Endpoints and Adverse Reproductive Development in Male Rats by Gray, Leon E, Furr, Johnathan R, Lambright, Christy S, Evans, Nicola, Hartig, Phillip C, Cardon, Mary C, Wilson, Vickie S, Hotchkiss, Andrew K, Conley, Justin M

“…Abstract Multiple molecular initiating events exist that disrupt male sexual differentiation in utero including androgen receptor (AR) antagonism and…”
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Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow by Ankley, Gerald T., Jensen, Kathleen M., Makynen, Elizabeth A., Kahl, Michael D., Korte, Joseph J., Hornung, Michael W., Henry, Tala R., Denny, Jeffrey S., Leino, Richard L., Wilson, Vickie S., Cardon, Mary C., Hartig, Phillip C., Gray, L. Earl

“…Trenbolone acetate is a synthetic steroid that is extensively used in the United States as a growth promoter in beef cattle. The acetate is administered to…”
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Competitive binding comparison of endocrine-disrupting compounds to recombinant androgen receptor from fathead minnow, rainbow trout, and human by Wilson, V.S, Cardon, M.C, Gray, L.E. Jr, Hartig, P.C

“…Typically, in vitro hazard assessments for the identification of endocrine‐disrupting compounds (EDCs), including those outlined in the Endocrine Disruptor…”
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Public and private tapwater: Comparative analysis of contaminant exposure and potential risk, Cape Cod, Massachusetts, USA by Bradley, Paul M., LeBlanc, Denis R., Romanok, Kristin M., Smalling, Kelly L., Focazio, Michael J., Cardon, Mary C., Clark, Jimmy M., Conley, Justin M., Evans, Nicola, Givens, Carrie E., Gray, James L., Earl Gray, L., Hartig, Phillip C., Higgins, Christopher P., Hladik, Michelle L., Iwanowicz, Luke R., Loftin, Keith A., Blaine McCleskey, R., McDonough, Carrie A., Medlock-Kakaley, Elizabeth K., Weis, Christopher P., Wilson, Vickie S.

“…•Lack of comparable private/public tapwater (TW) data undermines decision-making.•TW (10 private, 10 public), with same groundwater source, compared at Cape…”
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Comparison of Chemical Binding to Recombinant Fathead Minnow and Human Estrogen Receptors Alpha in Whole Cell and Cell-free Binding Assays by Rider, Cynthia V, Hartig, Phillip C, Cardon, Mary C, Wilson, Vickie S

“…Mammalian receptors and assay systems are generally used for in vitro screening of endocrine-disrupting chemicals with the assumption that minor differences in…”
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Cumulative and Antagonistic Effects of a Mixture of the Antiandrogens Vinclozolin and Iprodione in the Pubertal Male Rat by Blystone, Chad R., Lambright, Christy S., Cardon, Mary C., Furr, Johnathan, Rider, Cynthia V., Hartig, Phillip C., Wilson, Vickie S., Gray, Leon E.

“…Vinclozolin and iprodione are dicarboximide fungicides that display antiandrogenic effects in the male rat, which suggests that a mixture would lead to…”
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