Search Results - "Hartiala, Jaana A."

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma by Han, Yi, Jia, Qiong, Jahani, Pedram Shafiei, Hurrell, Benjamin P., Pan, Calvin, Huang, Pin, Gukasyan, Janet, Woodward, Nicholas C., Eskin, Eleazar, Gilliland, Frank D., Akbari, Omid, Hartiala, Jaana A., Allayee, Hooman

“…Asthma is a chronic and genetically complex respiratory disease that affects over 300 million people worldwide. Here, we report a genome-wide analysis for…”
Get full text

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection by Hilser, James R., Han, Yi, Biswas, Subarna, Gukasyan, Janet, Cai, Zhiheng, Zhu, Ruowei, Tang, W.H. Wilson, Deb, Arjun, Lusis, Aldons J., Hartiala, Jaana A., Allayee, Hooman

“…Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel…”
Get full text

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease by Hartiala, Jaana A., Wilson Tang, W. H., Wang, Zeneng, Crow, Amanda L., Stewart, Alexandre F. R., Roberts, Robert, McPherson, Ruth, Erdmann, Jeanette, Willenborg, Christina, Hazen, Stanley L., Allayee, Hooman

“…Metabolites derived from dietary choline and L -carnitine, such as trimethylamine N -oxide and betaine, have recently been identified as novel risk factors for…”
Get full text

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity by Maazi, Hadi, Hartiala, Jaana A, Suzuki, Yuzo, Crow, Amanda L, Shafiei Jahani, Pedram, Lam, Jonathan, Patel, Nisheel, Rigas, Diamanda, Han, Yi, Huang, Pin, Eskin, Eleazar, Lusis, Aldons J, Gilliland, Frank D, Akbari, Omid, Allayee, Hooman

“…Asthma is a chronic inflammatory disease of the airways with contributions from genes, environmental exposures, and their interactions. While genome-wide…”
Get full text

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk by Li, Xinmin S, Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A, Nemet, Ina, Hurd, Alex G, Gu, Xiaodong, Skye, Sarah M, Roberts, Adam B, Wu, Yuping, Li, Lin, Shahen, Christopher J, Wagner, Matthew A, Hartiala, Jaana A, Kerby, Robert L, Romano, Kymberleigh A, Han, Yi, Obeid, Slayman, Lüscher, Thomas F, Allayee, Hooman, Rey, Federico E, DiDonato, Joseph A, Fiehn, Oliver, Tang, W H Wilson, Hazen, Stanley L

“…Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts (N = 1,162), we discovered and structurally identified a plasma…”
Get full text

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease by Jia, Qiong, Han, Yi, Huang, Pin, Woodward, Nicholas C, Gukasyan, Janet, Kettunen, Johannes, Ala-Korpela, Mika, Anufrieva, Olga, Wang, Qin, Perola, Markus, Raitakari, Olli, Lehtimäki, Terho, Viikari, Jorma, Järvelin, Marjo-Riitta, Boehnke, Michael, Laakso, Markku, Mohlke, Karen L, Fiehn, Oliver, Wang, Zeneng, Tang, W H Wilson, Hazen, Stanley L, Hartiala, Jaana A, Allayee, Hooman

“…Background Recent studies have revealed sexually dimorphic associations between the carbamoyl-phosphate synthase 1 locus, intermediates of the metabolic…”
Get full text

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk by Ferrell, Marc, Wang, Zeneng, Anderson, James T., Li, Xinmin S., Witkowski, Marco, DiDonato, Joseph A., Hilser, James R., Hartiala, Jaana A., Haghikia, Arash, Cajka, Tomas, Fiehn, Oliver, Sangwan, Naseer, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Landmesser, Ulf, Tang, W. H. Wilson, Allayee, Hooman, Hazen, Stanley L.

“…Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all…”
Get full text

Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity by Sakano, Yoshihiro, Sakano, Kei, Hurrell, Benjamin P., Helou, Doumet Georges, Shafiei-Jahani, Pedram, Kazemi, Mohammad H., Li, Xin, Shen, Stephen, Hilser, James R., Hartiala, Jaana A., Allayee, Hooman, Barbers, Richard, Akbari, Omid

“…[Display omitted] Type 2 innate lymphoid cells (ILC2s) play a pivotal role in type 2 asthma. CD226 is a costimulatory molecule involved in various inflammatory…”
Get full text

COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type by Hilser, James R, Spencer, Neal J, Afshari, Kimia, Gilliland, Frank D, Hu, Howard, Deb, Arjun, Lusis, Aldons J, Wilson Tang, W H, Hartiala, Jaana A, Hazen, Stanley L, Allayee, Hooman

“…COVID-19 is associated with acute risk of major adverse cardiac events (MACE), including myocardial infarction, stroke, and mortality (all-cause). However, the…”
Get full text

Gene-Environment Interactions for Cardiovascular Disease by Hartiala, Jaana A., Hilser, James R., Biswas, Subarna, Lusis, Aldons J., Allayee, Hooman

“…Purpose of Review We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and…”
Get full text

Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices by Choucair, Ibrahim, Mallela, Deepthi P, Hilser, James R, Hartiala, Jaana A, Nemet, Ina, Gogonea, Valentin, Li, Lin, Lusis, Aldons J, Fischbach, Michael A, Tang, W H Wilson, Allayee, Hooman, Hazen, Stanley L

“…Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the…”
Get full text

Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk by Ferrell, Marc, Wang, Zeneng, Anderson, James T., Li, Xinmin S., Witkowski, Marco, DiDonato, Joseph A., Hilser, James R., Hartiala, Jaana A., Haghikia, Arash, Cajka, Tomas, Fiehn, Oliver, Sangwan, Naseer, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Landmesser, Ulf, Tang, W. H. Wilson, Allayee, Hooman, Hazen, Stanley L.

Get full text

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial by Schmidt, Kelsey A, Jones, Roshonda B, Rios, Claudia, Corona, Yesica, Berger, Paige K, Plows, Jasmine F, Alderete, Tanya L, Fogel, Jennifer, Hampson, Hailey, Hartiala, Jaana A, Cai, Zhiheng, Allayee, Hooman, Nayak, Krishna S, Sinatra, Frank R, Harlan, Gregory, Pickering, Trevor A, Salvy, Sarah-Jeanne, Mack, Wendy Jean, Kohli, Rohit, Goran, Michael I

“…Nonalcoholic fatty liver disease (NAFLD) among Latinos is partially attributed to a prevalent C>G polymorphism in the patatin-like phospholipase 3 (PNPLA3)…”
Get more information

Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women by Hilser, James R, Hartiala, Jaana A, Sriprasert, Intira, Kono, Naoko, Cai, Zhiheng, Karim, Roksana, DeYoung, Joseph, Mack, Wendy J, Hodis, Howard N, Allayee, Hooman

“…Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention strategies in women are not as…”
Get full text

Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017) by Barrington, William T., Salvador, Anna C., Hartiala, Jaana A., De Caterina, Raffaele, Kohlmeier, Martin, Martinez, J. Alfredo, Kreutzer, Carin B., Heber, David, Lusis, Aldons J., Li, Zhaoping, Allayee, Hooman

“…The International Society of Nutrigenetics and Nutrigenomics (ISNN) held its 11th annual Congress in Los Angeles, California, between September 16 and 19,…”
Get full text

GENOME-WIDE ANALYSIS IDENTIFIES SORCS3 AS A NOVEL SUSCEPTIBILITY LOCUS FOR PANIC DISORDER IN THE FINNGEN STUDY by Naamanka, Joonas, Tasanko, Elisa, Trontti, Kalevi, Novak, Božidar, Suvisaari, Jaana, Paunio, Tiina, Vaht, Mariliis, Mattheisen, Manuel, Meier, Sandra, Metspalu, Andres, Daly, Mark, Erhardt-Lehmann, Angelika, Turck, Christoph W., Hartiala, Jaana A., Hovatta, Iiris

Get full text

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction: Eur Heart J by Hartiala, Jaana A, Han, Yi, Jia, Qiong, Hilser, James R, Huang, Pin, Gukasyan, Janet, Schwartzman, William S, Cai, Zhiheng, Biswas, Subarna, Tregouet, David-Alexandre, Smith, Nicholas L, Seldin, Marcus, Pan, Calvin, Mehrabian, Margarete, Lusis, Aldons J, Bazeley, Peter, Sun, Yan V, Liu, Chang, Quyyumi, Arshed A, Scholz, Markus, Thiery, Joachim, Delgado, Graciela E, Kleber, Marcus E, März, Winfried, Howe, Laurence J, Asselbergs, Folkert W, van Vugt, Marion, Vlachojannis, Georgios J, Patel, Riyaz S, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Tuomo V M, Kuukasjärvi, Pekka, Laurikka, Jari O, Chang, Xuling, Heng, Chew-Kiat, Jiang, Rong, Kraus, William E, Hauser, Elizabeth R, Ferguson, Jane F, Reilly, Muredach P, Ito, Kaoru, Koyama, Satoshi, Kamatani, Yoichiro, Komuro, Issei, Stolze, Lindsey K, Romanoski, Casey E, Khan, Mohammad Daud, Turner, Adam W, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, Ma, Lijiang, Björkegren, Johan L M, Kumar, S Ram, Tang, W H Wilson, Hazen, Stanley L, Allayee, Hooman

“…While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI…”
Get full text

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis by Schillemans, Tessa, Tragante, Vinicius, Maitusong, Buamina, Gigante, Bruna, Cresci, Sharon, Laguzzi, Federica, Vikström, Max, Richards, Mark, Pilbrow, Anna, Cameron, Vicky, Foco, Luisa, Doughty, Robert N., Kuukasjärvi, Pekka, Allayee, Hooman, Hartiala, Jaana A., Tang, W. H. Wilson, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Laurikka, Jari O., Srinivasan, Sundararajan, Mordi, Ify R., Trompet, Stella, Kraaijeveld, Adriaan, van Setten, Jessica, Gijsberts, Crystel M., Maitland-van der Zee, Anke H., Saely, Christoph H., Gong, Yan, Johnson, Julie A., Cooper-DeHoff, Rhonda M., Pepine, Carl J., Casu, Gavino, Leiherer, Andreas, Drexel, Heinz, Horne, Benjamin D., van der Laan, Sander W., Marziliano, Nicola, Hazen, Stanley L., Sinisalo, Juha, Kähönen, Mika, Lehtimäki, Terho, Lang, Chim C., Burkhardt, Ralph, Scholz, Markus, Jukema, J. Wouter, Eriksson, Niclas, Åkerblom, Axel, James, Stefan, Held, Claes, Hagström, Emil, Spertus, John A., Algra, Ale, de Faire, Ulf, Åkesson, Agneta, Asselbergs, Folkert W., Patel, Riyaz S., Leander, Karin

“…Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One…”
Get full text

Abstract 15300: Genetic Determinants of Plasma Glycine Levels Are Associated With Coronary Artery Disease: Meta-Analysis of Genome-Wide Association Studies in ~105,000 Subjects of European Ancestry by Hartiala, Jaana A, Tang, W.H Wilson, Wang, Zeneng, Erdmann, Jeanette, Hazen, Stanley L, Allayee, Hooman

“…We recently identified a variant (rs715) in carbamoyl phosphatase 1 (CPS1) on chr2q34 that was strongly associated with plasma betaine and glycine levels, and…”
Get full text