Search Results - "Harter, Patrick N"

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma by Eskilsson, Eskil, Røsland, Gro V, Solecki, Gergely, Wang, Qianghu, Harter, Patrick N, Graziani, Grazia, Verhaak, Roel G W, Winkler, Frank, Bjerkvig, Rolf, Miletic, Hrvoje

“…Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing…”
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SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes by Bojkova, Denisa, Wagner, Julian U G, Shumliakivska, Mariana, Aslan, Galip S, Saleem, Umber, Hansen, Arne, Luxán, Guillermo, Günther, Stefan, Pham, Minh Duc, Krishnan, Jaya, Harter, Patrick N, Ermel, Utz H, Frangakis, Achilleas S, Milting, Hendrik, Zeiher, Andreas M, Klingel, Karin, Cinatl, Jindrich, Dendorfer, Andreas, Eschenhagen, Thomas, Tschöpe, Carsten, Ciesek, Sandra, Dimmeler, Stefanie

“…Abstract Aims Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic…”
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CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy by Burger, Michael C, Zhang, Congcong, Harter, Patrick N, Romanski, Annette, Strassheimer, Florian, Senft, Christian, Tonn, Torsten, Steinbach, Joachim P, Wels, Winfried S

“…Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. Despite multimodal treatment regimens, median…”
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Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas by Zeiner, Pia S., Preusse, Corinna, Golebiewska, Anna, Zinke, Jenny, Iriondo, Ane, Muller, Arnaud, Kaoma, Tony, Filipski, Katharina, Müller‐Eschner, Monika, Bernatz, Simon, Blank, Anna‐Eva, Baumgarten, Peter, Ilina, Elena, Grote, Anne, Hansmann, Martin L., Verhoff, Marcel A., Franz, Kea, Feuerhake, Friedrich, Steinbach, Joachim P., Wischhusen, Jörg, Stenzel, Werner, Niclou, Simone P., Harter, Patrick N., Mittelbronn, Michel

“…While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune…”
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Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma by Mastrella, Giorgia, Hou, Mengzhuo, Li, Min, Stoecklein, Veit M, Zdouc, Nina, Volmar, Marie N M, Miletic, Hrvoje, Reinhard, Sören, Herold-Mende, Christel C, Kleber, Susanne, Eisenhut, Katharina, Gargiulo, Gaetano, Synowitz, Michael, Vescovi, Angelo L, Harter, Patrick N, Penninger, Josef M, Wagner, Ernst, Mittelbronn, Michel, Bjerkvig, Rolf, Hambardzumyan, Dolores, Schüller, Ulrich, Tonn, Jörg-Christian, Radke, Josefine, Glass, Rainer, Kälin, Roland E

“…Antiangiogenic therapy of glioblastoma (GBM) with bevacizumab, a VEGFA-blocking antibody, may accelerate tumor cell invasion and induce alternative angiogenic…”
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Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy by Maurer, Gabriele D, Brucker, Daniel P, Bähr, Oliver, Harter, Patrick N, Hattingen, Elke, Walenta, Stefan, Mueller-Klieser, Wolfgang, Steinbach, Joachim P, Rieger, Johannes

“…Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy…”
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Infratentorial IDH-mutant astrocytoma is a distinct subtype by Banan, Rouzbeh, Stichel, Damian, Bleck, Anja, Hong, Bujung, Lehmann, Ulrich, Suwala, Abigail, Reinhardt, Annekathrin, Schrimpf, Daniel, Buslei, Rolf, Stadelmann, Christine, Ehlert, Karoline, Prinz, Marco, Acker, Till, Schittenhelm, Jens, Kaul, David, Schweizer, Leonille, Capper, David, Harter, Patrick N., Etminan, Nima, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, Reuss, David E.

“…Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of…”
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Patterns of intersectional tumor volumes in T2-weighted MRI and [18F]FET PET in adult glioma: a prospective, observational study by Weller, Jonathan, Unterrainer, Marcus, Sonderer, Markéta, Katzendobler, Sophie, Holzgreve, Adrien, Biczok, Annamaria, Harter, Patrick N., Tonn, Joerg-Christian, Albert, Nathalie L., Suchorska, Bogdana

“…Brain tumor volumes as assessed by magnetic resonance imaging (MRI) do not always spatially overlap with biological tumor volumes (BTV) measured by [ 18…”
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Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinoma by Risolino, Maurizio, Mandia, Nadia, Iavarone, Francescopaolo, Dardaei, Leila, Longobardi, Elena, Fernandez, Serena, Talotta, Francesco, Bianchi, Fabrizio, Pisati, Federica, Spaggiari, Lorenzo, Harter, Patrick N, Mittelbronn, Michel, Schulte, Dorothea, Incoronato, Mariarosaria, Di Fiore, Pier Paolo, Blasi, Francesco, Verde, Pasquale

“…Significance Epithelial–mesenchymal transition (EMT) is a transdifferentiation program implicated in tumor cell dissemination, controlled by networks of…”
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Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma by Scholz, Alexander, Harter, Patrick N, Cremer, Sebastian, Yalcin, Burak H, Gurnik, Stefanie, Yamaji, Maiko, Di Tacchio, Mariangela, Sommer, Kathleen, Baumgarten, Peter, Bähr, Oliver, Steinbach, Joachim P, Trojan, Jörg, Glas, Martin, Herrlinger, Ulrich, Krex, Dietmar, Meinhardt, Matthias, Weyerbrock, Astrid, Timmer, Marco, Goldbrunner, Roland, Deckert, Martina, Braun, Christian, Schittenhelm, Jens, Frueh, Jochen T, Ullrich, Evelyn, Mittelbronn, Michel, Plate, Karl H, Reiss, Yvonne

“…Glioblastoma multiforme (GBM) is treated by surgical resection followed by radiochemotherapy. Bevacizumab is commonly deployed for anti‐angiogenic therapy of…”
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Mid-Gestation lethality of Atxn2l -Ablated Mice by Key, Jana, Harter, Patrick N, Sen, Nesli-Ece, Gradhand, Elise, Auburger, Georg, Gispert, Suzana

“…Depletion of yeast/fly Ataxin-2 rescues TDP-43 overexpression toxicity. In mouse models of Amyotrophic Lateral Sclerosis via TDP-43 overexpression, depletion…”
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CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis by Loreth, Desiree, Schuette, Moritz, Zinke, Jenny, Mohme, Malte, Piffko, Andras, Schneegans, Svenja, Stadler, Julia, Janning, Melanie, Loges, Sonja, Joosse, Simon A., Lamszus, Katrin, Westphal, Manfred, Müller, Volkmar, Glatzel, Markus, Matschke, Jakob, Gebhardt, Christoffer, Schneider, Stefan W., Belczacka, Iwona, Volkmer, Beate, Greinert, Rüdiger, Yaspo, Marie-Laure, Harter, Patrick N., Pantel, Klaus, Wikman, Harriet

“…Up to 40% of advance lung, melanoma and breast cancer patients suffer from brain metastases (BM) with increasing incidence. Here, we assessed whether…”
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Classification of meningiomas-advances and controversies by Harter, Patrick N, Braun, Yannick, Plate, Karl H

“…Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although approximately 80% of the tumors are slow growing and benign, some…”
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Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors by Walter, Dirk, Harter, Patrick N., Battke, Florian, Winkelmann, Ria, Schneider, Markus, Holzer, Katharina, Koch, Christine, Bojunga, Jörg, Zeuzem, Stefan, Hansmann, Martin Leo, Peveling-Oberhag, Jan, Waidmann, Oliver

“…Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim of this study was to…”
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Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation by Torres-Odio, Sylvia, Key, Jana, Hoepken, Hans-Hermann, Canet-Pons, Júlia, Valek, Lucie, Roller, Bastian, Walter, Michael, Morales-Gordo, Blas, Meierhofer, David, Harter, Patrick N, Mittelbronn, Michel, Tegeder, Irmgard, Gispert, Suzana, Auburger, Georg

“…PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson's disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the…”
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Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke by Spitzer, Daniel, Puetz, Tim, Armbrust, Moritz, Dunst, Maika, Macas, Jadranka, Croll, Florian, Plate, Karl-Heinz, Reiss, Yvonne, Liebner, Stefan, Harter, Patrick N., Guérit, Sylvaine, Devraj, Kavi

“…Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain…”
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Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases by Harter, Patrick N, Bernatz, Simon, Scholz, Alexander, Zeiner, Pia S, Zinke, Jenny, Kiyose, Makoto, Blasel, Stella, Beschorner, Rudi, Senft, Christian, Bender, Benjamin, Ronellenfitsch, Michael W, Wikman, Harriet, Glatzel, Markus, Meinhardt, Matthias, Juratli, Tareq A, Steinbach, Joachim P, Plate, Karl H, Wischhusen, Jörg, Weide, Benjamin, Mittelbronn, Michel

“…The activation of immune cells by targeting checkpoint inhibitors showed promising results with increased patient survival in distinct primary cancers. Since…”
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MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients by Doberstein, Kai, Steinmeyer, Nico, Hartmetz, Ann-Kathrin, Eberhardt, Wolfgang, Mittelbronn, Michel, Harter, Patrick N, Juengel, Eva, Blaheta, Roman, Pfeilschifter, Josef, Gutwein, Paul

“…Abstract A disintegrin and metalloproteinase 17 (ADAM17) is a metalloprotease that is overexpressed in many cancer types, including renal cancers. However, the…”
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Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia by Peng, Hao, Xin, Shan, Pfeiffer, Susanne, Müller, Constanze, Merl-Pham, Juliane, Hauck, Stefanie M., Harter, Patrick N., Spitzer, Daniel, Devraj, Kavi, Varynskyi, Borys, Arzberger, Thomas, Momma, Stefan, Schick, Joel A.

“…The progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive…”
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IGF1R Is a Potential New Therapeutic Target for HGNET-BCOR Brain Tumor Patients by Vewinger, Nadine, Huprich, Sabrina, Seidmann, Larissa, Russo, Alexandra, Alt, Francesca, Bender, Hannah, Sommer, Clemens, Samuel, David, Lehmann, Nadine, Backes, Nora, Roth, Lea, Harter, Patrick N, Filipski, Katharina, Faber, Jörg, Paret, Claudia

“…(1) The high-grade neuroepithelial tumor of the central nervous system with BCOR alteration (HGNET-BCOR) is a highly malignant tumor. Preclinical models and…”
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