Search Results - "Harte, Alison L"

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes by Piya, Milan K, Harte, Alison L, Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D, James, Sean, Sabico, Shaun, Al-Daghri, Nasser M, Saravanan, Ponnusamy, Barber, Thomas M, Kumar, Sudhesh, Vatish, Manu, McTernan, Philip G

“…Peripheral action of irisin improves glucose homeostasis and increases energy expenditure, with no data on a central role of irisin in metabolism. These…”
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High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects by Harte, Alison L, Varma, Madhusudhan C, Tripathi, Gyanendra, McGee, Kirsty C, Al-Daghri, Nasser M, Al-Attas, Omar S, Sabico, Shaun, O’Hare, Joseph P, Ceriello, Antonio, Saravanan, Ponnusamy, Kumar, Sudhesh, McTernan, Philip G

“…OBJECTIVE: To evaluate the changes in circulating endotoxin after a high–saturated fat meal to determine whether these effects depend on metabolic disease…”
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Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects by Al-Daghri, Nasser M., Alkharfy, Khalid M., Rahman, Shakilur, Amer, Osama E., Vinodson, Benjamin, Sabico, Shaun, Piya, Milan K., Harte, Alison L., McTernan, Philip G., Alokail, Majed S., Chrousos, George P.

“…Background Irisin, a novel myokine, increases energy expenditure and glucose tolerance and, thus, improves carbohydrate homeostasis in humans. This hormone has…”
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Elevated endotoxin levels in non-alcoholic fatty liver disease by Harte, Alison L, da Silva, Nancy F, Creely, Steven J, McGee, Kirsty C, Billyard, Thomas, Youssef-Elabd, Elham M, Tripathi, Gyanendra, Ashour, Esmat, Abdalla, Mohga S, Sharada, Hayat M, Amin, Ashraf I, Burt, Alastair D, Kumar, Sudhesh, Day, Christopher P, McTernan, Philip G

“…Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine…”
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Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease by Baker, Adam R, Silva, Nancy F da, Quinn, David W, Harte, Alison L, Pagano, Domenico, Bonser, Robert S, Kumar, Sudhesh, McTernan, Philip G

“…Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial…”
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Does endotoxaemia contribute to osteoarthritis in obese patients? by Metcalfe, David, Harte, Alison L, Aletrari, Mina Olga, Al Daghri, Nasser M, Al Disi, Dara, Tripathi, Gyanendra, McTernan, Philip G

“…OA (osteoarthritis) is a degenerative condition associated with obesity. A number of metabolic explanations have been proposed to explain the association…”
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Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies by Al-Attas, Omar S, Al-Daghri, Nasser M, Al-Rubeaan, Khalid, da Silva, Nancy F, Sabico, Shaun L, Kumar, Sudhesh, McTernan, Philip G, Harte, Alison L

“…Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting…”
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Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass by Kos, Katarina, Harte, Alison L, James, Sean, Snead, David R, O'Hare, Joseph P, McTernan, Philip G, Kumar, Sudhesh

“…NPY is an important central orexigenic hormone, but little is known about its peripheral actions in human adipose tissue (AT) or its potential paracrine…”
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Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population by Miller, Michelle A, McTernan, Philip G, Harte, Alison L, Silva, Nancy F. da, Strazzullo, Pasquale, Alberti, K. George M.M, Kumar, Sudhesh, Cappuccio, Francesco P

“…Abstract Background Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be…”
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Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytes by McGee, Kirsty C, Harte, Alison L, da Silva, Nancy F, Al-Daghri, Nasser, Creely, Steven J, Kusminski, Christine M, Tripathi, Gyanendra, Levick, Paul L, Khanolkar, Manish, Evans, Marc, Chittari, Madhu V, Patel, Vinod, Kumar, Sudhesh, McTernan, Philip G

“…Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipose tissue and correlated with obesity. However, recent…”
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Increased circulating ANG II and TNF-α represents important risk factors in obese saudi adults with hypertension irrespective of diabetic status and BMI by Al-Daghri, Nasser M, Bindahman, Lotfi S, Al-Attas, Omar S, Saleem, Tahia H, Alokail, Majed S, Alkharfy, Khalid M, Draz, Hossam M, Yakout, Sobhy, Mohamed, Amany O, Harte, Alison L, McTernan, Philip G

“…Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal…”
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Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro by MCTERNAN, Philip G, HARTE, Alison L, ANDERSON, Leah A, GREEN, Allan, SMITH, Stephen A, HOLDER, Julie C, BARNETT, Anthony H, EGGO, Margaret C, KUMAR, Sudhesh

“…Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro Philip G. McTernan 1 , Alison L. Harte 1 , Leah A. Anderson…”
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Metabolic endotoxaemia: is it more than just a gut feeling? by Piya, Milan K., Harte, Alison L., McTernan, Philip G.

“…This article reviews the evidence linking gut bacteria, endotoxin, and its circulating levels with inflammatory induced obesity and metabolic disease…”
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GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress by Schisano, Bruno, Harte, Alison L., Lois, Konstantinos, Saravanan, Ponnusamy, Al-Daghri, Nasser, Al-Attas, Omar, Knudsen, Lotte B., McTernan, Philip G., Ceriello, Antonio, Tripathi, Gyanendra

“…Hyperglycemia induced endoplasmic reticulum (ER) stress in diabetic vascular cells is considered an increasingly important factor for the genesis and…”
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Adiponectin and Resistin in Human Cerebrospinal Fluid and Expression of Adiponectin Receptors in the Human Hypothalamus by Kos, Katarina, Harte, Alison L., da Silva, Nancy F., Tonchev, Anton, Chaldakov, Georgi, James, Sean, Snead, David R., Hoggart, Barbara, O’Hare, Joseph P., McTernan, Philip G., Kumar, Sudhesh

“…Context: The adipokine leptin has critical importance in central appetite regulation. In contrast to some suggestion of adiponectin influencing energy…”
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Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro by Youssef-Elabd, Elham M, McGee, Kirsty C, Tripathi, Gyanendra, Aldaghri, Nasser, Abdalla, Mohga S, Sharada, Hayat M, Ashour, Esmat, Amin, Ashraf I, Ceriello, Antonio, O'Hare, Joseph P, Kumar, Sudhesh, McTernan, Philip G, Harte, Alison L

“…A post-prandial increase in saturated fatty acids (SFAs) and glucose (Glc) activates an inflammatory response, which may be prolonged following restoration of…”
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Response to comment on: Harte et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care 2012;35:375-382 by Harte, Alison L, McTernan, Philip G

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NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFα by Harte, Alison L., Tripathi, Gyanendra, Piya, Milan K., Barber, Thomas M., Clapham, John C., Al‐Daghri, Nasser, Al‐Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, Joseph P., Kumar, Sudhesh, McTernan, Philip G.

“…Objective Central obesity and sub‐clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue…”
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The in Vitro Effects of Resistin on the Innate Immune Signaling Pathway in Isolated Human Subcutaneous Adipocytes by Kusminski, Christine M., da Silva, Nancy F., Creely, Steven J., Fisher, Ffolliott M., Harte, Alison L., Baker, Adam R., Kumar, Sudhesh, McTernan, Philip G.

“…Context: Obesity-associated inflammation is a contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM); the mechanisms underlying the…”
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Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus by Harte, Alison L., da Silva, Nancy F., Miller, Michelle A., Cappuccio, Francesco P., Kelly, Ann, O’Hare, Joseph P., Barnett, Anthony H., Al-Daghri, Nasser M., Al-Attas, Omar, Alokail, Majed, Sabico, Shaun, Tripathi, Gyanendra, Bellary, Srikanth, Kumar, Sudhesh, McTernan, Philip G.

“…South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature…”
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