Search Results - "Hart‐Smith, Gene"

Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues by Hamey, Joshua J., Rakow, Sinja, Bouchard, Caroline, Senst, Johanna M., Kolb, Peter, Bauer, Uta‐Maria, Wilkins, Marc R., Hart‐Smith, Gene

“…Protein arginine methyltransferase 6 (PRMT6) catalyses the asymmetric dimethylation of arginines on numerous substrate proteins within the human cell. In…”
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MS2‐Deisotoper: A Tool for Deisotoping High‐Resolution MS/MS Spectra in Normal and Heavy Isotope‐Labelled Samples by Tay, Aidan P., Liang, Angelita, Hamey, Joshua J., Hart‐Smith, Gene, Wilkins, Marc R.

“…High‐resolution MS/MS spectra of peptides can be deisotoped to identify monoisotopic masses of peptide fragments. The use of such masses should improve protein…”
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Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p by Yagoub, Daniel, Hart-Smith, Gene, Moecking, Jonas, Erce, Melissa A., Wilkins, Marc R.

“…The Hmt1 methyltransferase is the predominant arginine methyltransferase in Saccharomyces cerevisiae. There are 18 substrate proteins described for this…”
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The methylproteome and the intracellular methylation network by Erce, Melissa A., Pang, Chi N. I., Hart-Smith, Gene, Wilkins, Marc R.

“…Since its discovery more than 50 years ago, post‐translational modification (PTM) of proteins via methylation has grown in prominence, its involvement having…”
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Polymer-Albumin Conjugate for the Facilitated Delivery of Macromolecular Platinum Drugs by Dag, Aydan, Jiang, Yanyan, Karim, Khairil Juhanni Abd, Hart-Smith, Gene, Scarano, Wei, Stenzel, Martina H.

“…The delivery of macromolecular platinum drugs into cancerous cells is enhanced by conjugating the polymer to albumin. The monomers…”
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A review of electron-capture and electron-transfer dissociation tandem mass spectrometry in polymer chemistry by Hart-Smith, Gene

“…•ECD and ETD can produce unique and diagnostically useful polymer ion fragmentation data.•The operating principles of ECD and ETD are discussed in relation to…”
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The activity of a yeast Family 16 methyltransferase, Efm2, is affected by a conserved tryptophan and its N‐terminal region by Hamey, Joshua J., Hart‐Smith, Gene, Erce, Melissa A., Wilkins, Marc R.

“…The Family 16 methyltransferases are a group of eukaryotic nonhistone protein methyltransferases. Sixteen of these have recently been described in yeast and…”
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Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase by Chua, Ngee Kiat, Hart-Smith, Gene, Brown, Andrew J.

“…Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis. The region comprising the first 100 amino acids, termed SM N100, represents the…”
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The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S] by Luu, Winnie, Hart-Smith, Gene, Sharpe, Laura J., Brown, Andrew J.

“…Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires…”
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Control of Cognate Sense mRNA Translation by cis-Natural Antisense RNAs by Deforges, Jules, Reis, Rodrigo S, Jacquet, Philippe, Sheppard, Shaoline, Gadekar, Veerendra P, Hart-Smith, Gene, Tanzer, Andrea, Hofacker, Ivo L, Iseli, Christian, Xenarios, Ioannis, Poirier, Yves

“…Cis-Natural Antisense Transcripts (cis-NATs), which overlap protein coding genes and are transcribed from the opposite DNA strand, constitute an important…”
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Detection and Characterization of Low Abundance Glycopeptides Via Higher-Energy C-Trap Dissociation and Orbitrap Mass Analysis by Hart-Smith, Gene, Raftery, Mark J.

“…Broad-scale mass spectrometric analyses of glycopeptides are constrained by the considerable complexity inherent to glycoproteomics, and techniques are still…”
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Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation by McIntyre, Kim L, Waters, Shafagh A, Zhong, Ling, Hart-Smith, Gene, Raftery, Mark, Chew, Zahra A, Patel, Hardip R, Graves, Jennifer A Marshall, Waters, Paul D

“…The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the…”
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Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes by Bouchard, Caroline, Sahu, Peeyush, Meixner, Marion, Nötzold, René Reiner, Rust, Marco B., Kremmer, Elisabeth, Feederle, Regina, Hart-Smith, Gene, Finkernagel, Florian, Bartkuhn, Marek, Savai Pullamsetti, Soni, Nist, Andrea, Stiewe, Thorsten, Philipsen, Sjaak, Bauer, Uta-Maria

“…Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to…”
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A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B by Soboleva, Tatiana A, Parker, Brian J, Nekrasov, Maxim, Hart-Smith, Gene, Tay, Ying Jin, Tng, Wei-Quan, Wilkins, Marc, Ryan, Daniel, Tremethick, David J

“…The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B…”
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Lysine methylation modulates the protein-protein interactions of yeast cytochrome C Cyc1p by Winter, Daniel L., Abeygunawardena, Dhanushi, Hart-Smith, Gene, Erce, Melissa A., Wilkins, Marc R.

“…In recent years, protein methylation has been established as a major intracellular PTM. It has also been proposed to modulate protein‐protein interactions…”
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Contemporary Mass Spectrometry and the Analysis of Synthetic Polymers: Trends, Techniques and Untapped Potential by Hart-Smith, Gene, Barner-Kowollik, Christopher

“…For many decades, the capacity for mass spectrometry (MS) to analyse matter in all of its forms was shackled by an inability to ionise large molecules into the…”
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Improved Quantitative Plant Proteomics via the Combination of Targeted and Untargeted Data Acquisition by Hart-Smith, Gene, Reis, Rodrigo S, Waterhouse, Peter M, Wilkins, Marc R

“…Quantitative proteomics strategies - which are playing important roles in the expanding field of plant molecular systems biology - are traditionally designated…”
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Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays by Low, Jason K. K., Im, Hogune, Erce, Melissa A., Hart-Smith, Gene, Snyder, Michael P., Wilkins, Marc R.

“…Arginine methylation on nonhistone proteins is associated with a number of cellular processes including RNA splicing, protein localization, and the formation…”
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Living Star Polymer Formation: Detailed Assessment of Poly(acrylate) Radical Reaction Pathways via ESI-MS by Hart-Smith, Gene, Chaffey-Millar, Hugh, Barner-Kowollik, Christopher

“…The generation of star polymers via living polymerization protocols is well documented; however, the impact of midchain radicals (MCRs) on the precise…”
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Degradation of Poly(methyl methacrylate) Model Compounds Under Extreme Environmental Conditions by Bennet, Francesca, Hart-Smith, Gene, Gruendling, Till, Davis, Thomas P., Barker, Philip J., Barner-Kowollik, Christopher

“…There is a significant knowledge gap in the degradation of poly(methyl methacrylate) (pMMA) under conditions experienced by surface coatings in the harsh…”
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