Search Results - "Hart, Timothy K."

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC by Mohammad, Helai P., Smitheman, Kimberly N., Kamat, Chandrashekhar D., Soong, David, Federowicz, Kelly E., Van Aller, Glenn S., Schneck, Jess L., Carson, Jeffrey D., Liu, Yan, Butticello, Michael, Bonnette, William G., Gorman, Shelby A., Degenhardt, Yan, Bai, Yuchen, McCabe, Michael T., Pappalardi, Melissa B., Kasparec, Jiri, Tian, Xinrong, McNulty, Kenneth C., Rouse, Meagan, McDevitt, Patrick, Ho, Thau, Crouthamel, Michelle, Hart, Timothy K., Concha, Nestor O., McHugh, Charles F., Miller, William H., Dhanak, Dashyant, Tummino, Peter J., Carpenter, Christopher L., Johnson, Neil W., Hann, Christine L., Kruger, Ryan G.

“…Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in epigenetic machinery have become a major focus for targeted therapies…”
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Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database by Monticello, Thomas M., Jones, Thomas W., Dambach, Donna M., Potter, David M., Bolt, Michael W., Liu, Maggie, Keller, Douglas A., Hart, Timothy K., Kadambi, Vivek J.

“…The contribution of animal testing in drug development has been widely debated and challenged. An industry-wide nonclinical to clinical translational database…”
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RhoA Signaling Is Required for Respiratory Syncytial Virus-Induced Syncytium Formation and Filamentous Virion Morphology by GOWER, Tara L, PASTEY, Manoj K, PEEPLES, Mark E, COLLINS, Peter L, MCCURDY, Lewis H, HART, Timothy K, GUTH, Alex, JOHNSON, Teresa R, GRAHAM, Barney S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss by Fedoriw, Andrew, Rajapurkar, Satyajit R., O'Brien, Shane, Gerhart, Sarah V., Mitchell, Lorna H., Adams, Nicholas D., Rioux, Nathalie, Lingaraj, Trupti, Ribich, Scott A., Pappalardi, Melissa B., Shah, Niyant, Laraio, Jenny, Liu, Yan, Butticello, Michael, Carpenter, Chris L., Creasy, Caretha, Korenchuk, Susan, McCabe, Michael T., McHugh, Charles F., Nagarajan, Raman, Wagner, Craig, Zappacosta, Francesca, Annan, Roland, Concha, Nestor O., Thomas, Roberta A., Hart, Timothy K., Smith, Jesse J., Copeland, Robert A., Moyer, Mikel P., Campbell, John, Stickland, Kim, Mills, James, Jacques-O’Hagan, Suzanne, Allain, Christina, Johnston, Danielle, Raimondi, Alejandra, Porter Scott, Margaret, Waters, Nigel, Swinger, Kerren, Boriack-Sjodin, Ann, Riera, Tom, Shapiro, Gideon, Chesworth, Richard, Prinjha, Rabinder K., Kruger, Ryan G., Barbash, Olena, Mohammad, Helai P.

“…Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of arginines on proteins. Type I PRMTs and their substrates have been…”
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Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys by Hart, Timothy K., Cook, Richard M., Zia-Amirhosseini, Parnian, Minthorn, Elisabeth, Sellers, Teresa S., Maleeff, Beverly E., Eustis, Scot, Schwartz, Lester W., Tsui, Ping, Appelbaum, Edward R., Martin, Elise C., Bugelski, Peter J., Herzyk, Danuta J.

“…Background: Allergic respiratory diseases are characterized by large numbers of eosinophils and their reactive products in airways and blood; these are…”
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Do longer duration nonclinical toxicology studies provide predictive clinical safety value? The IQ consortium longer duration nonclinical to clinical translational database by Monticello, Thomas M., Potter, David M., Huang, Qihong, Hart, Timothy K., Shuey, Dana, Troth, Sean, Vergis, James M., Tassew, Nardos, Glascott, Peter

“…The IQ Consortium's DruSafe Leadership Group previously reported results of a nonclinical to clinical translational database for First-In-Human (FIH)-enabling…”
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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective by Reynolds, Vincent L., Butler, Paul, Abernathy, Matthew M., Aschenbrenner, Laura, Best, Derek D., Blank, Jim, Crosby, Meredith, Custer, Laura, Escobar, Patricia A., Kolaja, Kyle, Moggs, Jonathan, Shuey, Dana, Snyder, Chelsea, Van Vleet, Terry, Zhou, Junguo, Hart, Timothy K.

“…Pharmaceutic products designed to perturb the function of epigenetic modulators have been approved by regulatory authorities for treatment of advanced cancer…”
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Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice by HERZYK, Danuta J, GORE, Elizabeth R, POLSKY, Rodd, NADWODNY, Kimberly L, MAIER, Curtis C, LIU, Susan, HART, Timothy K, HARMSEN, Allen G, BUGELSKI, Peter J

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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century by O’Neill, Paul M, Park, B. Kevin, Shone, Alison E, Maggs, James L, Roberts, Phillip, Stocks, Paul A, Biagini, Giancarlo A, Bray, Patrick G, Gibbons, Peter, Berry, Neil, Winstanley, Peter A, Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Hart, Timothy K, Gresham, Stephanie L, Lawrence, Ron M, Brigandi, Richard A, Gomez-delas-Heras, Federico M, Gargallo, Domingo V, Ward, Stephen A

“…N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and developed as part of a public−private partnership between academics at…”
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In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone by YUE, Tian-Li, JUN CHEN, HART, Timothy K, BUCKINGHAM, Robin E, OHLSTEIN, Eliot H, WEIKE BAO, NARAYANAN, Padma K, BRIL, Antoine, WEN JIANG, LYSKO, Paul G, GU, Juan-Li, BOYCE, Rogely, ZIMMERMAN, Dawn M

“…Diabetes is associated with increased risk of mortality as a consequence of acute myocardial infarction. This study determined whether rosiglitazone (ROSI)…”
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A Novel Technique For Mapping the Lipid Composition of Atherosclerotic Fatty Streaks by En Face Fluorescence Microscopy by Klinkner, Anne M, Bugelski, Peter J, Waites, C. Robbie, Louden, Calvert, Hart, Timothy K, Kerns, William D

“…We introduce here a new fluorescence microscopy technique for en face analysis of the atherosclerotic fatty streaks (FS). This technique is semiquantitative…”
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Effects of Troglitazone on HepG2 Viability and Mitochondrial Function by Tirmenstein, Mark A., Hu, Catherine X., Gales, Tracy L., Maleeff, Beverly E., Narayanan, Padma K., Kurali, Edit, Hart, Timothy K., Thomas, Heath C., Schwartz, Lester W.

“…Troglitazone (TRO), a member of the thiazolidinedione class of drugs, has been associated with hepatotoxicity in patients. The following in vitro study was…”
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2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression by Yue, T L, Wang, X, Louden, C S, Gupta, S, Pillarisetti, K, Gu, J L, Hart, T K, Lysko, P G, Feuerstein, G Z

“…2-Methoxyestradiol (2-ME) is an endogenous metabolite of estradiol-17beta and the oral contraceptive agent 17-ethylestradiol. 2-ME was recently reported to…”
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Chronic Hypoxia-Induced Cardiopulmonary Changes in Three Rat Strains: Inhibition by the Endothelin Receptor Antagonist SB 217242 by Underwood, David C, Bochnowicz, Steven, Osborn, Ruth R, Louden, Calvert S, Hart, Timothy K, Ohlstein, Eliot H, Hay, Douglas W. P

“…The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar…”
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Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3 by Yue, Tian-Li, Wang, Chuanlin, Romanic, Anne M, Kikly, Kristine, Keller, Paul, DeWolf Jr, Watler E, Hart, Timothy K, Thomas, Heath C, Storer, Barbara, Gu, Juan-Li, Wang, Xinkang, Feuerstein, Giora Z

“…Cardiomyocyte apoptosis has been demonstrated in animal models of cardiac injury as well as in patients with congestive heart failure or acute myocardial…”
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Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke by TOOMEY, John R, VALOCIK, Richard E, KOSTER, Paul F, GABRIEL, Melanie A, MCVEY, Matt, HART, Timothy K, OHLSTEIN, Eliot H, PARSONS, Andrew A, BARONE, Frank C

“…Although used clinically to prevent stroke, there are few examples of anticoagulant investigations in the treatment of acute thromboembolic stroke in animal…”
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Preclinical Safety of Recombinant Human Interleukin-18 by Herzyk, Danuta J., Bugelski, Peter J., Hart, Timothy K., Wier, Patrick J.

“…Recombinant human interleukin-18 (rHuIL-18) is currently in clinical trials for treatment of cancer. This report presents results of preclinical toxicity…”
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In vitro models to predict blood-brain barrier permeability by Eddy, Evangeline Priya, Maleef, Beverly E., Hart, Timothy K., Smith, Philip L.

“…The design and selection of centrally acting pharmaceuticals is a major challenge for drug delivery to the brain. This review discusses the use of…”
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Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4 by Sharma, A, Davis, C B, Tobia, L A, Kwok, D C, Tucci, M G, Gore, E R, Herzyk, D J, Hart, T K

“…Keliximab and clenoliximab are monkey/human chimeric CD4 monoclonal antibodies (mAbs) of the IgG1 and IgG4 isotypes, respectively. The pharmacokinetics (PK)…”
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Pharmacokinetics and tissue distribution of SB-251353, a novel human CXC chemokine, after intravenous administration to mice by Hepburn, T W, Hart, T K, Horton, V L, Sellers, T S, Tobia, L P, Urbanski, J J, Shi, W, Davis, C B

“…The pharmacokinetics and tissue distribution of SB-251353, a novel truncated form of the human CXC chemokine growth-related gene product beta, were studied…”
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