Search Results - "Hart, L S"

Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: Targetable nanocomplexes for in vivo nucleic acid delivery by Tagalakis, A.D., Maeshima, R., Yu-Wai-Man, C., Meng, J., Syed, F., Wu, L.-P., Aldossary, A.M., McCarthy, D., Moghimi, S.M., Hart, S.L.

“…[Display omitted] One of the greatest challenges for the development of genetic therapies is the efficient targeted delivery of therapeutic nucleic acids…”
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Treatment of depression for patients with multiple sclerosis in neurology clinics by Mohr, D C, Hart, S L, Fonareva, I, Tasch, E S

“…The objective of this study was to examine the adequacy of antidepressant pharmacotherapy in a sample of patients with multiple sclerosis (MS) treated by…”
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Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI by Pugh, J. A. T., Cox, A. G., McLeod, C. W., Bunch, J., Writer, M. J., Hart, S. L., Bienemann, A., White, E., Bell, J.

“…Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used to map the spatial distribution of magnetic resonance imaging (MRI)…”
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Screening for depression among patients with multiple sclerosis: two questions may be enough by Mohr, Dc, Hart, Sl, Julian, L, Tasch, Es

“…Background Depression among patients with multiple sclerosis (MS) is common and has a significant impact on quality of life. As many as two-thirds of depressed…”
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Prospects for RNA delivery with nanotechnologies by Hart, S L

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Development and assessment of the constipation-related disability scale by Hart, S. L., Albiani, J. J., Crangle, C. J., Torbit, L. A., Varma, M. G.

“…Aliment Pharmacol Ther 2012; 35: 183–192 Summary Background  Chronic constipation is associated with impaired quality of life and physical discomfort. Although…”
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Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12 by BARKER, S. E, GROSSE, S. M, SIAPATI, E. K, KRITZ, A, KINNON, C, THRASHER, A. J, HART, S. L

“…Cytokine-modified tumour cells have been used in clinical trials for immunotherapy of neuroblastoma, but primary tumour cells from surgical biopsies are…”
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Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects by Moore, P.K., Wallace, P., Gaffen, Z., Hart, S.L., Babbedge, R.C.

“…1 7‐Nitro indazole (7‐NI, 10–50 mg kg−1), 6‐nitro indazole and indazole (25–100 mg kg−1) administered i.p. in the mouse produce dose‐related antinociception in…”
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Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation by Spencer, H, Rampling, D, Aurora, P, Bonnet, D, Hart, S L, Jaffé, A

“…Background: Recent reports have shown evidence of host derived parenchymal engraftment in several human allografts including the lung, leading to speculation…”
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Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles by Babbedge, R.C., Bland‐Ward, P.A., Hart, S.L., Moore, P.K.

“…1 7‐Nitro indazole (7‐NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 ± 0.1 μm (n = 6). NOS activity is…”
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Pharmacological and antimicrobial studies on different tea-tree oils (Melaleuca alternifolia, Leptospermum scoparium or Manuka and Kunzea ericoides or Kanuka), originating in Australia and New Zealand by Lis-Balchin, M., Hart, S. L., Deans, S. G.

“…Three different species of Myrtaceae growing in Australia and New Zealand are known as ‘Tea‐tree’: the Australian Tea tree (Melaleuca alternifolia), the New…”
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7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure by Moore, P.K., Babbedge, R.C., Wallace, P., Gaffen, Z.A., Hart, S.L.

“…7‐Nitro indazole (7‐NI) inhibits mouse cerebellar nitric oxide synthase (NOS) in vitro with an IC50 of 0.47 μm. Following i.p. administration in mice, 7‐NI…”
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Integrin-mediated transfection with peptides containing arginine-glycine-aspartic acid domains by HART, S. L, COLLINS, L, GUSTAFSSON, K, FABRE, J. W

“…Two synthetic peptides comprising an RGD moiety for integrin binding and a polylysine moiety for DNA binding were tested for transfection efficiency under a…”
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An integrin-targeted non-viral vector for pulmonary gene therapy by JENKINS, R. G, HERRICK, S. E, MENG, Q.-H, KINNON, C, LAURENT, G. J, MCANULTY, R. J, HART, S. L

“…Gene therapy offers potential for the treatment of severe respiratory diseases. However, the vectors which are currently available have drawbacks limiting…”
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l‐NG‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse by Moore, P.K., Oluyomi, A.O., Babbedge, R.C., Wallace, P., Hart, S.L.

“…1 l‐NG‐nitro arginine methyl ester (l‐NAME, 1–75 mg kg−1) administered intraperitoneally (i.p.) elicits dose‐related antinociception in the mouse assessed by…”
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Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo by JENKINS, R. G, MENG, Q-H, HODGES, R. J, LEE, L. K, BOTTOMS, S. E. W, LAURENT, G. J, WILLIS, D, AYAZI SHAMLOU, P, MCANULTY, R. J, HART, S. L

“…There is currently an urgent need to develop efficient gene-delivery systems for the lung that are free of inflammatory effects. The LID vector is a synthetic…”
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Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity by Ashique, A M, Hart, L S, Thomas, C D L, Clement, J G, Pivonka, P, Carter, Y, Mousseau, D D, Cooper, D M L

“…The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed…”
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Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide by HART, S. L, KNIGHT, A. M, HARBOTTLE, R. P, MISTRY, A, HUNGER, H.-D, CUTLER, D. F, WILLIAMSON, R, COUTELLE, C

“…Ligands that bind mammalian cell surface integrins with high affinity can mediate cellular internalization. We show that particles of the bacteriophage fd that…”
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Gene delivery to hypoxic cells in vitro by DACHS, G. U, CORALLI, C, HART, S. L, TOZER, G. M

“…Hypoxia in solid tumours has been correlated with poor prognosis and resistance to radiation and chemotherapy. Hypoxia is also a strong stimulus for gene…”
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Stable integration of large (> 100 kb) PAC constructs in HaCaT keratinocytes using an integrin-targeting peptide delivery system by COMPTON, S. H, MECKLENBECK, S, HOVNANIAN, A, MEJIA, J. E, HART, S. L, RICE, M, CERVINI, R, BARRANDON, Y, LARIN, Z, LEVY, E. R, BRUCKNER-TUDERMAN, L

“…Transfer of large DNA constructs in gene therapy studies is being recognised for its importance in maintaining the natural genomic environment of the gene of…”
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