Soluble extracts from carioca beans (Phaseolus vulgaris L.) affect the gut microbiota and iron related brush border membrane protein expression in vivo (Gallus gallus)

Soluble extracts from carioca beans (Phaseolus vulgaris L.) affect the gut microbiota and iron related brush border membrane protein expression in vivo (Gallus gallus)

The effect of soluble extracts with putative prebiotic ability extracted from various bean varieties on the intestinal brush border membrane (BBM) iron related proteins, and intestinal bacterial populations were evaluated using the Gallus gallus model and by the intra-amniotic administration procedu...

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Bibliographic Details
Published in:Food research international Vol. 123; pp. 172 - 180
Main Authors: Dias, Desirrê Morais, Kolba, Nikolai, Hart, Jon J., Ma, Michelle, Sha, Sybil T., Lakshmanan, Naveena, Nutti, Marilia Regini, Martino, Hércia Stampini Duarte, Glahn, Raymond P., Tako, Elad
Format: Journal Article
Language:English
Published: Canada Elsevier Ltd 01-09-2019
Subjects:
Biofortification
Brush border membrane
Common beans
Dietary fiber
Iron
Microbial populations
Common beans
FPN
Microbial populations
DMT1
Iron
BBM
AP
SI
Biofortification
Brush border membrane
ZnT1
Dietary fiber
Fe
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Summary:The effect of soluble extracts with putative prebiotic ability extracted from various bean varieties on the intestinal brush border membrane (BBM) iron related proteins, and intestinal bacterial populations were evaluated using the Gallus gallus model and by the intra-amniotic administration procedure. Eight treatment groups [(non-injected; 18 MΩ H2O; 40 mg/mL Inulin; 50 mg/mL BRS Perola (carioca standard); 50 mg/mL BRS Cometa (carioca, Fe biofortified); 50 mg/mL BRS Esteio (black, standard); 50 mg/mL SMN 39 (black, Fe biofortified); 50 mg/mL BRS Artico (white, standard)] were utilized. Tested groups reduced the relative abundance of Clostridium and E. coli compared to the Inulin group (positive control) and they did not affect the relative abundance of Bifidobacterium and Lactobacillus compared to the negative control (18MΩ H2O). The relative expression of zinc transporter 1, ferroportin and amino peptidase were up-regulated in the BRS Cometa group (Fe-biofortified carioca beans). Results suggest that soluble extracts from carioca beans may improve the iron bioavailability by affecting intestinal bacterial populations, and BBM functionality. [Display omitted] •Prebiotics from carioca beans increased the abundance of beneficial bacteria.•Prebiotics from carioca beans limited the amount of potentially pathogenic bacteria.•Prebiotics from carioca beans improved the intestinal function.•Prebiotics from carioca beans may contribute to the Fe (and zinc) transport.
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ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2019.04.060