Search Results - "Hart, Bryan E."

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy by Hart, Bryan E, Lee, Sunhee

“…Buruli ulcer (BU) vaccine design faces similar challenges to those observed during development of prophylactic tuberculosis treatments. Multiple BU vaccine…”
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Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer by Hart, Bryan E, Hale, Laura P, Lee, Sunhee

“…Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively…”
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Cell Surface Trafficking of TLR1 Is Differentially Regulated by the Chaperones PRAT4A and PRAT4B by Hart, Bryan E., Tapping, Richard I.

“…The subcellular localization of Toll-like receptors (TLRs) is critical to their ability to function as innate immune sensors of microbial infection. We…”
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Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria by Hart, Bryan E, Tapping, Richard I

“…We recently identified I602S as a frequent single-nucleotide polymorphism of human TLR1 that greatly inhibits cell surface trafficking, confers…”
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Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection by Hart, Bryan E., Tapping, Richard I.

“…Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with…”
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Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors by Hart, Bryan E, Asrican, Rose, Lim, So-Yon, Sixsmith, Jaimie D, Lukose, Regy, Souther, Sommer J R, Rayasam, Swati D G, Saelens, Joseph W, Chen, Ching-Ju, Seay, Sarah A, Berney-Meyer, Linda, Magtanong, Leslie, Vermeul, Kim, Pajanirassa, Priyadharshini, Jimenez, Amanda E, Ng, Tony W, Tobin, David M, Porcelli, Steven A, Larsen, Michelle H, Schmitz, Joern E, Haynes, Barton F, Jacobs, Jr, William R, Lee, Sunhee, Frothingham, Richard

“…The well-established safety profile of the tuberculosis vaccine strain, Mycobacterium bovis bacille Calmette-Guérin (BCG), makes it an attractive vehicle for…”
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Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer: e0004046 by Hart, Bryan E, Hale, Laura P, Lee, Sunhee

“…Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively…”
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TLR1 I602s: Trafficking dynamics and roles in resistance to mycobacterial infection by Hart, Bryan E

“…Innate immunity provides defense mechanisms required for protection against constant exposure to potentially pathogenic microorganisms. Essential to this role…”
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Immunogenicity and protection conferred by a recombinant Mycobacterium marinum vaccine against Buruli ulcer by Hart, Bryan E., Hale, Laura P., Lee, Sunhee

“…Mycobacterium ulcerans (MU) infection causes the disfiguring necrotic skin disease, Buruli ulcer (BU). While vaccination with Mycobacterium bovis BCG provides…”
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