Search Results - "Harst, P van der"

The single-cell eQTLGen consortium by van der Wijst, Mgp, de Vries, D H, Groot, H E, Trynka, G, Hon, C C, Bonder, M J, Stegle, O, Nawijn, M C, Idaghdour, Y, van der Harst, P, Ye, C J, Powell, J, Theis, F J, Mahfouz, A, Heinig, M, Franke, L

“…In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects…”
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The fibrosis marker galectin-3 and outcome in the general population by de Boer, R. A., van Veldhuisen, D. J., Gansevoort, R. T., Muller Kobold, A. C., van Gilst, W. H., Hillege, H. L., Bakker, S. J. L., van der Harst, P.

“…  de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege HL, Bakker SJL, van der Harst P (University of Groningen). The…”
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Telomere length loss due to smoking and metabolic traits by Huzen, J., Wong, L. S. M., Veldhuisen, D. J., Samani, N. J., Zwinderman, A. H., Codd, V., Cawthon, R. M., Benus, G. F. J. D., Horst, I. C.C., Navis, G., Bakker, S. J. L., Gansevoort, R. T., Jong, P. E., Hillege, H. L., Gilst, W. H., Boer, R. A., Harst, P.

“…Objectives Human age‐dependent telomere attrition and telomere shortening are associated with several age‐associated diseases and poorer overall survival. The…”
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Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample by Hoen, P W, Rosmalen, J G M, Schoevers, R A, Huzen, J, van der Harst, P, de Jonge, P

“…Telomere length is considered an emerging marker of biological aging. Depression and anxiety are associated with excess mortality risk but the mechanisms…”
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Genetically-determined body mass index and the risk of atrial fibrillation progression in men and women by Siland, J E, Nguyen, B O, de With, R R, Van Gelder, I C, van der Harst, P, Rienstra, M

“…Limited causal evidence is available on the relationship between body mass index (BMI) and atrial fibrillation (AF) progression. Sex differences have been…”
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Diagnostic performance of semi-quantitative and quantitative stress CMR perfusion analysis: a meta-analysis by van Dijk, R, van Assen, M, Vliegenthart, R, de Bock, G H, van der Harst, P, Oudkerk, M

“…Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high…”
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Vitamin D biology in heart failure: molecular mechanisms and systematic review by Meems, Laura M G, van der Harst, P, van Gilst, W H, de Boer, R A

“…Vitamin D has recently been suggested as an important mediator of blood pressure and cardiovascular disease, including heart failure. In patient with heart…”
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Novel endotypes in heart failure: effects on guideline-directed medical therapy by Tromp, J, Ouwerkerk, W, Demissei, B G, Anker, S D, Cleland, J G, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, H L, Lang, C C, Metra, M, Ng, L L, Ponikowski, P, Samani, N J, van Veldhuisen, D J, Zannad, F, Zwinderman, A H, Voors, A A, van der Meer, P

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Recurrent and founder mutations in the Netherlands—Phospholamban p.Arg14del mutation causes arrhythmogenic cardiomyopathy by van der Zwaag, P. A., van Rijsingen, I. A. W., de Ruiter, R., Nannenberg, E. A., Groeneweg, J. A., Post, J. G., Hauer, R. N. W., van Gelder, I. C., van den Berg, M. P., van der Harst, P., Wilde, A. A. M., van Tintelen, J. P.

“…Background Recently, we showed that the c.40_42delAGA (p.Arg14del) mutation in the phospholamban (PLN) gene can be identified in 10–15 % of Dutch patients with…”
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Angiotensin II Type 2 Receptor Vasoactivity in Internal Mammary Arteries of Patients With Coronary Artery Disease by Wal, R. M. A van de, Harst, P van der, Wagenaar, L J, Wassmann, S, Morshuis, W J, Nickenig, G, Buikema, H, Plokker, H W. M, van Veldhuisen, D J, van Gilst, W H, Voors, A A

“…BACKGROUND:Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are…”
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Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study by Ouwerkerk, W, Voors, A A, Anker, S D, Cleland, J G, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, H L, Lang, C C, Ter Maaten, J M, Ng, L L, Ponikowski, P, Samani, N J, van Veldhuisen, D J, Zannad, F, Metra, M, Zwinderman, A H

“…Despite clear guidelines recommendations, most patients with heart failure and reduced ejection-fraction (HFrEF) do not attain guideline-recommended target…”
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Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein(a) Concentration: Protective Missense Variant on Lipoprotein(a) Concentration—Brief Report by Said, M. Abdullah, Yeung, Ming Wai, van de Vegte, Yordi J., Benjamins, Jan Walter, Dullaart, Robin P.F., Ruotsalainen, Sanni, Ripatti, Samuli, Natarajan, Pradeep, Juarez-Orozco, Luis Eduardo, Verweij, Niek, van der Harst, P.

“…[Figure: see text]…”
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Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics by Arbustini, Eloisa, Behr, Elijah R, Carrier, Lucie, van Duijn, Cornelia, Evans, Paul, Favalli, Valentina, van der Harst, Pim, Haugaa, Kristina Hermann, Jondeau, Guillaume, Kääb, Stefan, Kaski, Juan Pablo, Kavousi, Maryam, Loeys, Bart, Pantazis, Antonis, Pinto, Yigal, Schunkert, Heribert, Di Toro, Alessandro, Thum, Thomas, Urtis, Mario, Waltenberger, Johannes, Elliott, Perry

“…Abstract This document describes the contribution of clinical criteria to the interpretation of genetic variants using heritable Mendelian cardiomyopathies as…”
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A primer in artificial intelligence in cardiovascular medicine by Benjamins, J. W., Hendriks, T., Knuuti, J., Juarez-Orozco, L. E., van der Harst, P.

“…Driven by recent developments in computational power, algorithms and web-based storage resources, machine learning (ML)-based artificial intelligence (AI) has…”
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Association of recognized and unrecognized myocardial infarction with depressive and anxiety disorders in 125,988 individuals: A report of the LifeLines cohort study by Roest, A., Iozzia, G., de Miranda Azevedo, R., van der Harst, P., Rosmalen, J., de Jonge, P.

“…Background No previous study examined the role of recognition of myocardial infarction (MI) and the presence of affective disorders in a large population…”
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Novel endotypes in heart failure: effects on guideline-directed medical therapy by Tromp, J, Ouwerkerk, W, Demissei, B G, Anker, S D, Cleland, J G, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, H L, Lang, C C, Metra, M, Ng, L L, Ponikowski, P, Samani, N J, van Veldhuisen, D J, Zannad, F, Zwinderman, A H, Voors, A A, van der Meer, P

“…We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers…”
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Routine reporting of grey-white matter differentiation in early brain computed tomography in comatose patients after cardiac arrest: A substudy of the COACT trial by Adriaansens, K.O., Jewbali, L.S.D., Lemkes, J.S., Spoormans, E.M., Meuwissen, M., Blans, M.J., van der Harst, P., Eikemans, B.J.W., Bleeker, G.B., Beishuizen, A., Henriques, J.P., van der Lugt, A., van Royen, N., den Uil, C.A.

“…A multimodal approach is advised for neurological prognostication in comatose patients after out-of-hospital cardiac arrest (OHCA). Grey-white matter…”
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Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease by Crawford, Andrew A, Bankier, Sean, Altmaier, Elisabeth, Barnes, Catriona L K, Clark, David W, Ermel, Raili, Friedrich, Nele, van der Harst, Pim, Joshi, Peter K, Karhunen, Ville, Lahti, Jari, Mahajan, Anubha, Mangino, Massimo, Nethander, Maria, Neumann, Alexander, Pietzner, Maik, Sukhavasi, Katyayani, Wang, Carol A, Bakker, Stephan J L, Bjorkegren, Johan L M, Campbell, Harry, Eriksson, Johan, Gieger, Christian, Hayward, Caroline, Jarvelin, Marjo-Riitta, McLachlan, Stela, Morris, Andrew P, Ohlsson, Claes, Pennell, Craig E, Price, Jackie, Rudan, Igor, Ruusalepp, Arno, Spector, Tim, Tiemeier, Henning, Völzke, Henry, Wilson, James F, Michoel, Tom, Timpson, Nicolas J, Smith, George Davey, Walker, Brian R

“…The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium…”
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Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium by Siland, J E, Geelhoed, B, Roselli, C, Wang, B, Lin, H J, Weiss, S, Trompet, S, van den Berg, M E, Soliman, E Z, Chen, L Y, Ford, I, Jukema, J W, Macfarlane, P W, Kornej, J, Lin, H, Lunetta, K L, Kavousi, M, Kors, J A, Ikram, M A, Guo, X, Yao, J, Dörr, M, Felix, S B, Völker, U, Sotoodehnia, N, Arking, D E, Stricker, B H, Heckbert, S R, Lubitz, S A, Benjamin, E J, Alonso, A, Ellinor, P T, van der Harst, P, Rienstra, M

“…Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped…”
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Genetic loci influencing kidney function and chronic kidney disease by Penninx, Brenda W, Waeber, Gerard, Prokopenko, Inga, Waterworth, Dawn, Dimkovic, Nada, Snieder, Harold, Shuldiner, Alan R, Ferrucci, Luigi, Gale, Daniel P, Dockrell, Mark, Swaminathan, Ramasamyiyer, Maréchal, Céline, Loos, Ruth J F, Peltonen, Leena, Abecasis, Goncalo R, Sanna, Serena, de Jong, Paul E, Ebrahim, Shah, Smit, Johannes H, Connell, John M C, Floege, Jurgen, Melander, Olle, Perucha, Esperanza, Seelen, Marc A J, Spector, Timothy D, Ahmadi, Kourosh R, Li, Yun, Mooser, Vincent, Schlessinger, David, Beckmann, Jacqui, Hepkema, Bouke G, Ubink-Veltmaat, Lielith J, Bakker, Stephan J L, Cook, H Terence, Vollenweider, Peter, Eggermann, Thomas, Sjögren, Marketa, Schalling, Martin, Jarvelin, Marjo-Riitta, Lightstone, Liz, Kooner, Jaspal S, Caulfield, Mark J, Dikkeschei, Lambert D, Farrall, Martin, Hedblad, Bo, Zerres, Klaus, McCarthy, Mark I, Samani, Nilesh J, Ruokonen, Aimo, Nordfors, Louise, de Silva, Ranil, Johnson, Toby, Lapsley, Marta, Gansevoort, Ron T, Scott, James, Brown, Morris J, Navis, Gerjan, Han, Xijin, Sehmi, Joban S, Bochud, Murielle, Hypponen, Elina, Schlieper, Georg, Bilo, Henk J G, Luan, Jian'an, Deng, Guohong, Wallace, Chris, Sternberg, Michael J E, Wass, Mark N, Elliott, Paul, Lagou, Vasiliki, Kleefstra, Nanne, Stenvinkel, Peter, Wareham, Nicholas J, Devuyst, Olivier, van der Harst, Pim, Maxwell, Patrick H, Cotlarciuc, Ioana, Pouta, Anneli, Lord, Graham M, Tanaka, Toshiko, Hernandez-Fuentes, Maria, Roderick, Paul J, Zhang, Weihua, Soranzo, Nicole, Chambers, John C, Uda, Manuela, Forouhi, Nita G, van der Heide, Jaap J Homan, Dominiczak, Anna, Luttropp, Karin, Parsa, Afshin, Lawlor, Debbie A, Munroe, Patricia B, Smith, George Davey

“…Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P…”
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