Search Results - "Harry J. Gilbert"

Biochemistry of complex glycan depolymerisation by the human gut microbiota by Ndeh, Didier, Gilbert, Harry J

“…The human gut microbiota (HGM) makes an important contribution to health and disease. It is a complex microbial community of trillions of microbes with a…”
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Biochemistry and Structural Biology of Plant Cell Wall Deconstruction by Gilbert, Harry J

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PULDB: the expanded database of Polysaccharide Utilization Loci by Terrapon, Nicolas, Lombard, Vincent, Drula, Élodie, Lapébie, Pascal, Al-Masaudi, Saad, Gilbert, Harry J, Henrissat, Bernard

“…Abstract The Polysaccharide Utilization Loci (PUL) database was launched in 2015 to present PUL predictions in ∼70 Bacteroidetes species isolated from the…”
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Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules by Gilbert, Harry J, Knox, J Paul, Boraston, Alisdair B

“…•Carbohydrate-binding modules (CBMs) display diverse specificity and structure.•A refined classification of CBM types is presented.•Advances in understanding…”
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Automatic prediction of polysaccharide utilization loci in Bacteroidetes species by Terrapon, Nicolas, Lombard, Vincent, Gilbert, Harry J, Henrissat, Bernard

“…A bacterial polysaccharide utilization locus (PUL) is a set of physically linked genes that orchestrate the breakdown of a specific glycan. PULs are prevalent…”
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Cellulosomes: highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates by Fontes, Carlos M G A, Gilbert, Harry J

“…Cellulosomes can be described as one of nature's most elaborate and highly efficient nanomachines. These cell bound multienzyme complexes orchestrate the…”
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Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts by Martens, Eric C, Lowe, Elisabeth C, Chiang, Herbert, Pudlo, Nicholas A, Wu, Meng, McNulty, Nathan P, Abbott, D Wade, Henrissat, Bernard, Gilbert, Harry J, Bolam, David N, Gordon, Jeffrey I

“…Symbiotic bacteria inhabiting the human gut have evolved under intense pressure to utilize complex carbohydrates, primarily plant cell wall glycans in our…”
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Expression system for structural and functional studies of human glycosylation enzymes by Moremen, Kelley W, Ramiah, Annapoorani, Stuart, Melissa, Steel, Jason, Meng, Lu, Forouhar, Farhad, Moniz, Heather A, Gahlay, Gagandeep, Gao, Zhongwei, Chapla, Digantkumar, Wang, Shuo, Yang, Jeong-Yeh, Prabhakar, Pradeep Kumar, Johnson, Roy, Rosa, Mitche dela, Geisler, Christoph, Nairn, Alison V, Seetharaman, Jayaraman, Wu, Sheng-Cheng, Tong, Liang, Gilbert, Harry J, LaBaer, Joshua, Jarvis, Donald L

“…A modular protein expression system enables the structural and functional characterization of human glycosyltransferases, glycoside hydrolases and other…”
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Glycan complexity dictates microbial resource allocation in the large intestine by Rogowski, Artur, Briggs, Jonathon A., Mortimer, Jennifer C., Tryfona, Theodora, Terrapon, Nicolas, Lowe, Elisabeth C., Baslé, Arnaud, Morland, Carl, Day, Alison M., Zheng, Hongjun, Rogers, Theresa E., Thompson, Paul, Hawkins, Alastair R., Yadav, Madhav P., Henrissat, Bernard, Martens, Eric C., Dupree, Paul, Gilbert, Harry J., Bolam, David N.

“…The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which…”
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Unusual active site location and catalytic apparatus in a glycoside hydrolase family by Munoz-Munoz, Jose, Cartmell, Alan, Terrapon, Nicolas, Henrissat, Bernard, Gilbert, Harry J.

“…The human gut microbiota use complex carbohydrates as major nutrients. The requirement for an efficient glycan degrading systems exerts a major selection…”
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Carbohydrate-binding modules: fine-tuning polysaccharide recognition by Boraston, Alisdair B, Bolam, David N, Gilbert, Harry J, Davies, Gideon J

“…The enzymic degradation of insoluble polysaccharides is one of the most important reactions on earth. Despite this, glycoside hydrolases attack such…”
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How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans by Cartmell, Alan, Lowe, Elisabeth C., Baslé, Arnaud, Firbank, Susan J., Ndeh, Didier A., Murray, Heath, Terrapon, Nicolas, Lombard, Vincent, Henrissat, Bernard, Turnbull, Jeremy E., Czjzek, Mirjam, Gilbert, Harry J., Bolam, David N.

“…The human microbiota, which plays an important role in health and disease, uses complex carbohydrates as a major source of nutrients. Utilization hierarchy…”
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Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects by Hervé, Cécile, Rogowski, Artur, Blake, Anthony W., Marcus, Susan E., Gilbert, Harry J., Knox, J. Paul, Cosgrove, Daniel J.

“…Cell wall degrading enzymes have a complex molecular architecture consisting of catalytic modules and noncatalytic carbohydrate-binding modules (CBMs). The…”
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Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides by Luis, Ana S., Briggs, Jonathon, Zhang, Xiaoyang, Farnell, Benjamin, Ndeh, Didier, Labourel, Aurore, Baslé, Arnaud, Cartmell, Alan, Terrapon, Nicolas, Stott, Katherine, Lowe, Elisabeth C., McLean, Richard, Shearer, Kaitlyn, Schückel, Julia, Venditto, Immacolata, Ralet, Marie-Christine, Henrissat, Bernard, Martens, Eric C., Mosimann, Steven C., Abbott, D. Wade, Gilbert, Harry J.

“…The major nutrients available to human colonic Bacteroides species are glycans, exemplified by pectins, a network of covalently linked plant cell wall…”
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An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins by Munoz-Munoz, José, Cartmell, Alan, Terrapon, Nicolas, Baslé, Arnaud, Henrissat, Bernard, Gilbert, Harry J.

“…The human gut microbiota utilizes complex carbohydrates as major nutrients. The requirement for efficient glycan degrading systems exerts a major selection…”
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Sulfation of Arabinogalactan Proteins Confers Privileged Nutrient Status to Bacteroides plebeius by Munoz-Munoz, Jose, Ndeh, Didier, Fernandez-Julia, Pedro, Walton, Gemma, Henrissat, Bernard, Gilbert, Harry J

“…The human gut microbiota (HGM) contributes to the physiology and health of its host. The health benefits provided by dietary manipulation of the HGM require…”
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Carbohydrate-binding module assisting glycosynthase-catalysed polymerizations by Codera, Victoria, Gilbert, Harry J, Faijes, Magda, Planas, Antoni

“…Carbohydrate-binding modules (CBMs) are found within multi-modular polysaccharide degrading enzymes [glycoside hydrolases (GHs)]. CBMs play a critical role in…”
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How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity by Cuskin, Fiona, Flint, James E., Gloster, Tracey M., Morland, Carl, Baslé, Arnaud, Henrissat, Bernard, Coutinho, Pedro M., Strazzulli, Andrea, Solovyova, Alexandra S., Davies, Gideon J., Gilbert, Harry J.

“…Noncatalytic carbohydrate binding modules (CBMs) are components of glycoside hydrolases that attack generally inaccessible substrates. CBMs mediate a two- to…”
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Restricted access of proteins to mannan polysaccharides in intact plant cell walls by Marcus, Susan E, Blake, Anthony W, Benians, Thomas A.S, Lee, Kieran J.D, Poyser, Callum, Donaldson, Lloyd, Leroux, Olivier, Rogowski, Artur, Petersen, Henriette L, Boraston, Alisdair, Gilbert, Harry J, Willats, William G.T, Paul Knox, J

“…How the diverse polysaccharides present in plant cell walls are assembled and interlinked into functional composites is not known in detail. Here, using two…”
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4-O-methylation of glucuronic acid in Arabidopsis glucuronoxylan is catalyzed by a domain of unknown function family 579 protein by Urbanowicz, Breeanna R, Peña, Maria J, Ratnaparkhe, Supriya, Avci, Utku, Backe, Jason, Steet, Heather F, Foston, Marcus, Li, Hongjia, O’Neill, Malcolm A, Ragauskas, Arthur J, Darvill, Alan G, Wyman, Charles, Gilbert, Harry J, York, William S

“…The hemicellulose 4- O -methyl glucuronoxylan is one of the principle components present in the secondary cell walls of eudicotyledonous plants. However, the…”
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