Search Results - "Harry, Emily"
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1
A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones using microwave heating
Published in Tetrahedron letters (25-04-2012)“…(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (7a–w) have been synthesized by the Knoevenagel condensation…”
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Journal Article -
2
Novel Mechanism for FcϵRI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production
Published in The Journal of biological chemistry (13-01-2012)“…Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is…”
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Journal Article -
3
Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone
Published in Biochemical pharmacology (15-02-2012)“…β-Lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) contribute significantly to the longevity of the β-lactam antibiotics used to treat serious…”
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Journal Article -
4
Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy
Published in Bioorganic & medicinal chemistry letters (01-01-2011)“…The importance of an H-bond donating substituent on the β-lactamase inhibitory activity was assessed through the synthesis and evaluation of a systematic…”
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Journal Article -
5
Useful intermediates for antibiotic synthesis
Published 01-01-2011“…Three studies were conducted to facilitate the design and synthesis of new, more efficient inhibitors of β-lactamase enzymes. A series of C6-substituted…”
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Dissertation -
6
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production
Published in The Journal of biological chemistry (13-01-2012)“…Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is…”
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Journal Article