Search Results - "Harrus, Deborah"

Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains by Khoder-Agha, Fawzi, Harrus, Deborah, Brysbaert, Guillaume, Lensink, Marc F., Harduin-Lepers, Anne, Glumoff, Tuomo, Kellokumpu, Sakari

“…β-1,4-Galactosyltransferase 1 (B4GALT1) and ST6 β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) catalyze the successive addition of terminal β-1,4–linked…”
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PDBe and PDBe‐KB: Providing high‐quality, up‐to‐date and integrated resources of macromolecular structures to support basic and applied research and education by Varadi, Mihaly, Anyango, Stephen, Appasamy, Sri Devan, Armstrong, David, Bage, Marcus, Berrisford, John, Choudhary, Preeti, Bertoni, Damian, Deshpande, Mandar, Leines, Grisell Diaz, Ellaway, Joseph, Evans, Genevieve, Gaborova, Romana, Gupta, Deepti, Gutmanas, Aleksandras, Harrus, Deborah, Kleywegt, Gerard J., Bueno, Weslley Morellato, Nadzirin, Nurul, Nair, Sreenath, Pravda, Lukas, Afonso, Marcelo Querino Lima, Sehnal, David, Tanweer, Ahsan, Tolchard, James, Abrams, Charlotte, Dunlop, Roisin, Velankar, Sameer

“…The archiving and dissemination of protein and nucleic acid structures as well as their structural, functional and biophysical annotations is an essential task…”
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The dimeric structure of wild-type human glycosyltransferase B4GalT1 by Harrus, Deborah, Khoder-Agha, Fawzi, Peltoniemi, Miika, Hassinen, Antti, Ruddock, Lloyd, Kellokumpu, Sakari, Glumoff, Tuomo

“…Most glycosyltransferases, including B4GalT1 (EC 2.4.1.38), are known to assemble into enzyme homomers and functionally relevant heteromers in vivo. However,…”
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Dataset from a human-in-the-loop approach to identify functionally important protein residues from literature by Vollmar, Melanie, Tirunagari, Santosh, Harrus, Deborah, Armstrong, David, Gáborová, Romana, Gupta, Deepti, Afonso, Marcelo Querino Lima, Evans, Genevieve, Velankar, Sameer

“…We present a novel system that leverages curators in the loop to develop a dataset and model for detecting structure features and functional annotations at…”
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A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I by Hassinen, Antti, Khoder-Agha, Fawzi, Khosrowabadi, Elham, Mennerich, Daniela, Harrus, Deborah, Noel, Maxence, Dimova, Elitsa Y, Glumoff, Tuomo, Harduin-Lepers, Anne, Kietzmann, Thomas, Kellokumpu, Sakari

“…Glycosylation, a common modification of cellular proteins and lipids, is often altered in diseases and pathophysiological states such as hypoxia, yet the…”
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Annotating Macromolecular Complexes in the Protein Data Bank: Improving the FAIRness of Structure Data by Appasamy, Sri Devan, Berrisford, John, Gaborova, Romana, Nair, Sreenath, Anyango, Stephen, Grudinin, Sergei, Deshpande, Mandar, Armstrong, David, Pidruchna, Ivanna, Ellaway, Joseph I. J., Leines, Grisell Díaz, Gupta, Deepti, Harrus, Deborah, Varadi, Mihaly, Velankar, Sameer

“…Macromolecular complexes are essential functional units in nearly all cellular processes, and their atomic-level understanding is critical for elucidating and…”
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Crystallization conditions in the Protein Data Bank by Harrus, Deborah

“…Abstract only…”
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Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution by Harrus, Deborah, Harduin-Lepers, Anne, Glumoff, Tuomo

“…[Display omitted] •The first unliganded and CMP-Neu5Ac bound structures of human ST6Gal I.•Sialylmotifs L, S and III bind the sialic acid moiety of the…”
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Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers by Harrus, Deborah, Kellokumpu, Sakari, Glumoff, Tuomo

“…Glycosyltransferases (GTases) transfer sugar moieties to proteins, lipids or existing glycan or polysaccharide molecules. GTases form an important group of…”
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Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405 by Scrima, Nathalie, Caillet-Saguy, Célia, Ventura, Michel, Harrus, Déborah, Astier-Gin, Thérèse, Bressanelli, Stéphane

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis by Harrus, Déborah, Ahmed-El-Sayed, Neveen, Simister, Philip C., Miller, Steve, Triconnet, Martine, Hagedorn, Curt H., Mahias, Kathleen, Rey, Félix A., Astier-Gin, Thérèse, Bressanelli, Stéphane

“…The hepatitis C virus (HCV) NS5b protein is an RNA-dependent RNA polymerase essential for replication of the viral RNA genome. In vitro and presumably in vivo,…”
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Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts by Kokkonen, Nina, Khosrowabadi, Elham, Hassinen, Antti, Harrus, Deborah, Glumoff, Tuomo, Kietzmann, Thomas, Kellokumpu, Sakari

“…Carcinoembryonic antigen (CEACAM5, CEA) is a known tumor marker for colorectal cancer that localizes in a polarized manner to the apical surface in normal…”
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Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures by Delfosse, Vanessa, Huet, Tiphaine, Harrus, Deborah, Granell, Meritxell, Bourguet, Maxime, Gardia-Parège, Caroline, Chiavarina, Barbara, Grimaldi, Marina, Le Mével, Sébastien, Blanc, Pauline, Huang, David, Gruszczyk, Jakub, Demeneix, Barbara, Cianférani, Sarah, Fini, Jean-Baptiste, Balaguer, Patrick, Bourguet, William

“…Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of literature links exposure to…”
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EMDB—the Electron Microscopy Data Bank by Turner, Jack, Abbott, Sanja, Fonseca, Neli, Pye, Ryan, Carrijo, Lucas, Duraisamy, Amudha Kumari, Salih, Osman, Wang, Zhe, Kleywegt, Gerard J, Morris, Kyle L, Patwardhan, Ardan, Burley, Stephen K, Crichlow, Gregg, Feng, Zukang, Flatt, Justin W, Ghosh, Sutapa, Hudson, Brian P, Lawson, Catherine L, Liang, Yuhe, Peisach, Ezra, Persikova, Irina, Sekharan, Monica, Shao, Chenghua, Young, Jasmine, Velankar, Sameer, Armstrong, David, Bage, Marcus, Bueno, Wesley Morellato, Evans, Genevieve, Gaborova, Romana, Ganguly, Sudakshina, Gupta, Deepti, Harrus, Deborah, Tanweer, Ahsan, Bansal, Manju, Rangannan, Vetriselvi, Kurisu, Genji, Cho, Hasumi, Ikegawa, Yasuyo, Kengaku, Yumiko, Kim, Ju Yaen, Niwa, Satomi, Sato, Junko, Takuwa, Ayako, Yu, Jian, Hoch, Jeffrey C, Baskaran, Kumaran, Xu, Wenqing, Zhang, Weizhe, Ma, Xiaodan

“…Abstract The Electron Microscopy Data Bank (EMDB) is the global public archive of three-dimensional electron microscopy (3DEM) maps of biological specimens…”
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Restraint validation of biomolecular structures determined by NMR in the Protein Data Bank by Baskaran, Kumaran, Ploskon, Eliza, Tejero, Roberto, Yokochi, Masashi, Harrus, Deborah, Liang, Yuhe, Peisach, Ezra, Persikova, Irina, Ramelot, Theresa A, Sekharan, Monica, Tolchard, James, Westbrook, John D, Bardiaux, Benjamin, Schwieters, Charles D, Patwardhan, Ardan, Velankar, Sameer, Burley, Stephen K, Kurisu, Genji, Hoch, Jeffrey C, Montelione, Gaetano T, Vuister, Geerten W, Young, Jasmine Y

“…Biomolecular structure analysis from experimental NMR studies generally relies on restraints derived from a combination of experimental and knowledge-based…”
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An integrated structure- and system-based framework to identify new targets of metabolites and known drugs by Naveed, Hammad, Hameed, Umar S, Harrus, Deborah, Bourguet, William, Arold, Stefan T, Gao, Xin

“…The inherent promiscuity of small molecules towards protein targets impedes our understanding of healthy versus diseased metabolism. This promiscuity also…”
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Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures by Delfosse, Vanessa, Huet, Tiphaine, Harrus, Deborah, Granell, Meritxell, Bourguet, Maxime, Gardia-Parège, Caroline, Chiavarina, Barbara, Grimaldi, Marina, Le Mével, Sébastien, Blanc, Pauline, Huang, David, Gruszczyk, Jakub, Demeneix, Barbara, Cianférani, Sarah, Fini, Jean-Baptiste, Balaguer, Patrick, Bourguet, William

“…Abstract only…”
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Molecular mechanisms of transcriptional control by Rev-erb[alpha]: An energetic foundation for reconciling structure and binding with biological function by Vaissiere, Anaïs, Berger, Sylvie, Harrus, Deborah, Dacquet, Catherine, Le Maire, Albane, Boutin, Jean A, Ferry, Gilles, Royer, Catherine A

“…Rev-erb[alpha] and [beta] are nuclear receptors that function as transcriptional repressors of genes involved in regulating circadian rhythms, glucose, and…”
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Molecular mechanisms of transcriptional control by Rev‐erbα: An energetic foundation for reconciling structure and binding with biological function by Vaissière, Anaïs, Berger, Sylvie, Harrus, Deborah, Dacquet, Catherine, Le Maire, Albane, Boutin, Jean A., Ferry, Gilles, Royer, Catherine A.

“…Rev‐erbα and β are nuclear receptors that function as transcriptional repressors of genes involved in regulating circadian rhythms, glucose, and cholesterol…”
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