Search Results - "Harroch, S"
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Pyk2 Regulates Multiple Signaling Events Crucial for Macrophage Morphology and Migration
Published in Proceedings of the National Academy of Sciences - PNAS (16-09-2003)“…The biological role of the protein tyrosine kinase, Pyk2, was explored by targeting the Pyk2 gene by homologous recombination. Pyk2-/- mice are viable and…”
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Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene
Published in Molecular psychiatry (01-02-2008)“…Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid…”
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Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation
Published in Neuroscience (03-11-2006)“…Perineuronal nets (PNs) are lattice-like condensations of the extracellular matrix (ECM) that envelop synapses and decorate the surface of subsets of neurons…”
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BACE (β-secretase) modulates the processing of APLP2 in vivo
Published in Molecular and cellular neuroscience (01-04-2004)“…BACE is an aspartyl protease that cleaves the amyloid precursor protein (APP) at the β-secretase cleavage site and is involved in Alzheimer's disease. The aim…”
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No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase β
Published in Molecular and Cellular Biology (01-10-2000)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The protein tyrosine phosphatase Rptpζ is expressed in differentiated osteoblasts and affects bone formation in mice
Published in Bone (New York, N.Y.) (01-03-2008)“…Abstract Tyrosine phosphorylation of intracellular substrates is one mechanism to regulate cellular proliferation and differentiation. Protein tyrosine…”
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Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina
Published in Neuroscience (27-03-2008)“…Abstract Receptor protein tyrosine phosphatases (RPTPs) appear to coordinate many aspects of neural development, including cell proliferation, migration and…”
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Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading
Published in Bone (New York, N.Y.) (01-05-2011)Get full text
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Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN‐alpha and IFN‐beta
Published in The EMBO journal (15-12-1994)“…The human interferon alpha‐receptor (IFNAR gene product) is a transmembranal protein of 557 amino acids with an intracytoplasmic domain of 100 amino acids…”
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Induction by interleukin‐6 of interferon regulatory factor 1 (IRF‐1) gene expression through the palindromic interferon response element pIRE and cell type‐dependent control of IRF‐1 binding to DNA
Published in The EMBO journal (15-04-1994)“…The effects of interleukin‐6 (IL‐6) on interferon regulatory factor 1 (IRF‐1) gene expression were studied in B‐hybridoma B9 cells which are growth‐stimulated…”
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Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes
Published in The Journal of biological chemistry (21-10-1994)“…Interferons (IFNs), as well as some interleukins, growth factors, and hormones, all induce tyrosine phosphorylation of STAT1 and additional transcription…”
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Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma : growth inhibition and differentiation of B16-F10.9 tumor cells
Published in Oncogene (31-07-1997)“…Interleukin-6 (IL-6) inhibits the growth of melanocytes and of early stage melanoma cells, but not that of advanced melanoma cells. The in vitro IL-6 response…”
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Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function
Published in Proceedings of the National Academy of Sciences - PNAS (12-12-2017)“…Epitranscriptomics refers to posttranscriptional alterations on an mRNA sequence that are dynamic and reproducible, and affect gene expression in a similar way…”
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Antagonism of interferon beta on interferon gamma: inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients
Published in Multiple sclerosis (1995)“…Interferon gamma (IFN-gamma acts as a mediator of multiple sclerosis (MS) exacerbations through a number of biological effects, such as induction of major…”
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Interleukin-6 activates and regulates transcription factors of the interferon regulatory factor family in M1 cells
Published in The Journal of biological chemistry (25-04-1993)“…Activation of (2'-5') A synthetase gene expression in interleukin-6 (IL-6)-treated myeloleukemic M1 cells correlates with protein binding to the interferon…”
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A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
Published in Nature genetics (01-11-2002)“…Several lines of evidence suggest that tyrosine phosphorylation is a key element in myelin formation, differentiation of oligodendrocytes and Schwann cells,…”
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Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system
Published in Journal of molecular neuroscience (01-01-2006)“…The cornerstone of cell signaling is largely based on the phosphorylation state that is defined by the equilibrium of the activity of protein kinases and…”
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The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in mice
Published in Bone (New York, N.Y.) (01-03-2008)“…Tyrosine phosphorylation of intracellular substrates is one mechanism to regulate cellular proliferation and differentiation. Protein tyrosine phosphatases…”
Get full text
Journal Article