Search Results - "Harrison, Thomas S."

Tackling the emerging threat of antifungal resistance to human health by Fisher, Matthew C., Alastruey-Izquierdo, Ana, Berman, Judith, Bicanic, Tihana, Bignell, Elaine M., Bowyer, Paul, Bromley, Michael, Brüggemann, Roger, Garber, Gary, Cornely, Oliver A., Gurr, Sarah. J., Harrison, Thomas S., Kuijper, Ed, Rhodes, Johanna, Sheppard, Donald C., Warris, Adilia, White, P. Lewis, Xu, Jianping, Zwaan, Bas, Verweij, Paul E.

“…Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis…”
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Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy by Williamson, Peter R., Jarvis, Joseph N., Panackal, Anil A., Fisher, Matthew C., Molloy, Síle F., Loyse, Angela, Harrison, Thomas S.

“…Key Points In most clinical centres in Africa, despite access to antiretroviral therapies, cases of HIV-associated cryptococcal meningitis (CM) are not…”
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The importance of antimicrobial resistance in medical mycology by Gow, Neil A. R., Johnson, Carolyn, Berman, Judith, Coste, Alix T., Cuomo, Christina A., Perlin, David S., Bicanic, Tihana, Harrison, Thomas S., Wiederhold, Nathan, Bromley, Mike, Chiller, Tom, Edgar, Keegan

“…Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have…”
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Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa by Molloy, Síle F, Kanyama, Cecilia, Heyderman, Robert S, Loyse, Angela, Kouanfack, Charles, Chanda, Duncan, Mfinanga, Sayoki, Temfack, Elvis, Lakhi, Shabir, Lesikari, Sokoine, Chan, Adrienne K, Stone, Neil, Kalata, Newton, Karunaharan, Natasha, Gaskell, Kate, Peirse, Mary, Ellis, Jayne, Chawinga, Chimwemwe, Lontsi, Sandrine, Ndong, Jean-Gilbert, Bright, Philip, Lupiya, Duncan, Chen, Tao, Bradley, John, Adams, Jack, van der Horst, Charles, van Oosterhout, Joep J, Sini, Victor, Mapoure, Yacouba N, Mwaba, Peter, Bicanic, Tihana, Lalloo, David G, Wang, Duolao, Hosseinipour, Mina C, Lortholary, Olivier, Jaffar, Shabbar, Harrison, Thomas S

“…Globally, cryptococcal meningitis is a leading cause of mortality among people with AIDS, despite the availability of effective amphotericin B–based therapy…”
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The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis by Dambuza, Ivy M, Drake, Thomas, Chapuis, Ambre, Zhou, Xin, Correia, Joao, Taylor-Smith, Leanne, LeGrave, Nathalie, Rasmussen, Tim, Fisher, Matthew C, Bicanic, Tihana, Harrison, Thomas S, Jaspars, Marcel, May, Robin C, Brown, Gordon D, Yuecel, Raif, MacCallum, Donna M, Ballou, Elizabeth R

“…Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis and niche adaptation. For example,…”
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Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial by Mfinanga, Sayoki, PhD, Chanda, Duncan, MD, Kivuyo, Sokoine L, MPhil, Guinness, Lorna, PhD, Bottomley, Christian, PhD, Simms, Victoria, PhD, Chijoka, Carol, BSW, Masasi, Ayubu, BSc, Kimaro, Godfather, MPH, Ngowi, Bernard, PhD, Kahwa, Amos, MSc, Mwaba, Peter, FRCP, Harrison, Thomas S, Prof, Egwaga, Saidi, PhD, Jaffar, Shabbar, Prof

“…Summary Background Mortality in people in Africa with HIV infection starting antiretroviral therapy (ART) is high, particularly in those with advanced disease…”
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Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America by Perfect, John R., Dismukes, William E., Dromer, Francoise, Goldman, David L., Graybill, John R., Hamill, Richard J., Harrison, Thomas S., Larsen, Robert A., Lortholary, Olivier, Nguyen, Minh-Hong, Pappas, Peter G., Powderly, William G., Singh, Nina, Sobel, Jack D., Sorrell, Tania C.

“…Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. These guidelines for its management have been built on the…”
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Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis by Jarvis, Joseph N, Meintjes, Graeme, Bicanic, Tihana, Buffa, Viviana, Hogan, Louise, Mo, Stephanie, Tomlinson, Gillian, Kropf, Pascale, Noursadeghi, Mahdad, Harrison, Thomas S

“…Understanding the host immune response during cryptococcal meningitis (CM) is of critical importance for the development of immunomodulatory therapies. We…”
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Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries by Loyse, Angela, MRes, Thangaraj, Harry, MBBS, Easterbrook, Philippa, Prof, Ford, Nathan, PhD, Roy, Monika, MD, Chiller, Tom, MD, Govender, Nelesh, MBBCh, Harrison, Thomas S, Prof, Bicanic, Tihana, BM BCh

“…Summary Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and contributes up to 20% of AIDS-related mortality in…”
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Screening for Cryptococcal Antigenemia in Patients Accessing an Antiretroviral Treatment Program in South Africa by Jarvis, Joseph N., Lawn, Stephen D., Vogt, Monica, Bangani, Nonzwakazi, Wood, Robin, Harrison, Thomas S.

“…Background. Cryptococcal meningitis is a leading cause of death in patients with acquired immunodeficiency syndrome and contributes substantially to the high…”
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Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa by Jarvis, Joseph N, Harrison, Thomas S, Lawn, Stephen D, Meintjes, Graeme, Wood, Robin, Cleary, Susan

“…Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at…”
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Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases by Jarvis, Joseph N, Meintjes, Graeme, Williams, Anthony, Brown, Yolande, Crede, Tom, Harrison, Thomas S

“…The presentation and causes of adult meningitis in South Africa have changed substantially as a result of HIV. Knowledge of aetiology and laboratory findings…”
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Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis by Sabiiti, Wilber, Robertson, Emma, Beale, Mathew A, Johnston, Simon A, Brouwer, Annemarie E, Loyse, Angela, Jarvis, Joseph N, Gilbert, Andrew S, Fisher, Matthew C, Harrison, Thomas S, May, Robin C, Bicanic, Tihana

“…Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor…”
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The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis by Kwon-Chung, Kyung J, Bennett, John E, Wickes, Brian L, Meyer, Wieland, Cuomo, Christina A, Wollenburg, Kurt R, Bicanic, Tihana A, Castañeda, Elizabeth, Chang, Yun C, Chen, Jianghan, Cogliati, Massimo, Dromer, Françoise, Ellis, David, Filler, Scott G, Fisher, Matthew C, Harrison, Thomas S, Holland, Steven M, Kohno, Shigeru, Kronstad, James W, Lazera, Marcia, Levitz, Stuart M, Lionakis, Michail S, May, Robin C, Ngamskulrongroj, Popchai, Pappas, Peter G, Perfect, John R, Rickerts, Volker, Sorrell, Tania C, Walsh, Thomas J, Williamson, Peter R, Xu, Jianping, Zelazny, Adrian M, Casadevall, Arturo

“…Cryptococcosis is a potentially lethal disease of humans/animals caused by and . Distinction between the two species is based on phenotypic and genotypic…”
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The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda by Lawrence, David S, Ssali, Agnes, Moshashane, Neo, Nabaggala, Georgina, Maphane, Lebogang, Harrison, Thomas S, Meya, David B, Jarvis, Joseph N, Seeley, Janet

“…The AMBITION-cm trial for HIV-associated cryptococcal meningitis demonstrated that a single, high-dose of liposomal amphotericin (AmBisome) plus 14-days of…”
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Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance by Hope, William, Stone, Neil R H, Johnson, Adam, McEntee, Laura, Farrington, Nicola, Santoro-Castelazo, Anahi, Liu, Xuan, Lucaci, Anita, Hughes, Margaret, Oliver, Jason D, Giamberardino, Charles, Mfinanga, Sayoki, Harrison, Thomas S, Perfect, John R, Bicanic, Tihana

“…Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be…”
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Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV-Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients by Bicanic, Tihana, Muzoora, Conrad, Brouwer, Annemarie E., Meintjes, Graeme, Longley, Nicky, Taseera, Kabanda, Rebe, Kevin, Loyse, Angela, Jarvis, Joseph, Bekker, Linda-Gail, Wood, Robin, Limmathurotsakul, Direk, Chierakul, Wirongrong, Stepniewska, Kasia, White, Nicholas J., Jaffar, Shabbar, Harrison, Thomas S.

“…Background. Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we…”
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Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa by Beale, Mathew A, Sabiiti, Wilber, Robertson, Emma J, Fuentes-Cabrejo, Karen M, O'Hanlon, Simon J, Jarvis, Joseph N, Loyse, Angela, Meintjes, Graeme, Harrison, Thomas S, May, Robin C, Fisher, Matthew C, Bicanic, Tihana

“…Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal…”
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Dose Response Effect of High-Dose Fluconazole for HIV-Associated Cryptococcal Meningitis in Southwestern Uganda by Longley, Nicky, Muzoora, Conrad, Taseera, Kabanda, Mwesigye, James, Rwebembera, Joselyne, Chakera, Ali, Wall, Emma, Andia, Irene, Jaffar, Shabbar, Harrison, Thomas S.

“…Background. Therapy for human immunodeficiency virus (HIV)–associated cryptococcal meningitis in many centers in Africa is fluconazole administered at a dosage…”
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On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members by Gemperle, Jakub, Harrison, Thomas S, Flett, Chloe, Adamson, Antony D, Caswell, Patrick T

“…CRISPR technology has made generation of gene knock-outs widely achievable in cells. However, once inactivated, their re-activation remains difficult,…”
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