Search Results - "Harrison, Theresa"

New perspectives on the basal forebrain cholinergic system in Alzheimer’s disease by Berry, Anne S., Harrison, Theresa M.

“…The basal forebrain cholinergic system (BFCS) has long been implicated in age-related cognitive changes and the pathophysiology of Alzheimer’s disease (AD)…”
Get full text

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging by Maass, Anne, Lockhart, Samuel N, Harrison, Theresa M, Bell, Rachel K, Mellinger, Taylor, Swinnerton, Kaitlin, Baker, Suzanne L, Rabinovici, Gil D, Jagust, William J

“…The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic-memory decline in aging and dementia. Postmortem…”
Get full text

Longitudinal tau accumulation and atrophy in aging and alzheimer disease by Harrison, Theresa M., La Joie, Renaud, Maass, Anne, Baker, Suzanne L., Swinnerton, Kaitlin, Fenton, Laura, Mellinger, Taylor J., Edwards, Lauren, Pham, Julie, Miller, Bruce L., Rabinovici, Gil D., Jagust, William J.

“…Objective To determine the rate of tau accumulation in healthy older adults (OA) and patients with Alzheimer disease (AD), as well as the relationship of tau…”
Get full text

Brain morphology, cognition, and β-amyloid in older adults with superior memory performance by Harrison, Theresa M., Maass, Anne, Baker, Suzanne L., Jagust, William J.

“…The mechanisms underlying superior cognitive performance in some older adults are poorly understood. We used a multimodal approach to characterize imaging and…”
Get full text

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging by Adams, Jenna N, Maass, Anne, Harrison, Theresa M, Baker, Suzanne L, Jagust, William J

“…Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer's disease (AD) is…”
Get full text

Tau deposition is associated with functional isolation of the hippocampus in aging by Harrison, Theresa M., Maass, Anne, Adams, Jenna N., Du, Richard, Baker, Suzanne L., Jagust, William J.

“…The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory…”
Get full text

Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain by Winer, Joseph R, Mander, Bryce A, Helfrich, Randolph F, Maass, Anne, Harrison, Theresa M, Baker, Suzanne L, Knight, Robert T, Jagust, William J, Walker, Matthew P

“…Recent proposals suggest that sleep may be a factor associated with accumulation of two core pathological features of Alzheimer's disease (AD): tau and…”
Get full text

Socioemotional and Behavioral Problems of Grandchildren Raised by Grandparents: The Role of Grandparent–Grandchild Relational Closeness and Conflict by Xu, Yanfeng, Harrison, Theresa

“…This study examined the associations of grandparent–grandchild relational closeness and conflict with grandchildren’s socioemotional and behavioral problems,…”
Get full text

Alzheimer's pathology targets distinct memory networks in the ageing brain by Maass, Anne, Berron, David, Harrison, Theresa M, Adams, Jenna N, La Joie, Renaud, Baker, Suzanne, Mellinger, Taylor, Bell, Rachel K, Swinnerton, Kaitlin, Inglis, Ben, Rabinovici, Gil D, Düzel, Emrah, Jagust, William J

“…Alzheimer's disease researchers have been intrigued by the selective regional vulnerability of the brain to amyloid-β plaques and tau neurofibrillary tangles…”
Get full text

Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [18F]-AV-1451 PET data by Young, Christina B., Landau, Susan M., Harrison, Theresa M., Poston, Kathleen L., Mormino, Elizabeth C.

“…Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the Alzheimer's disease (AD) continuum…”
Get full text

Alzheimer’s Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging by Cassady, Kaitlin E, Adams, Jenna N, Chen, Xi, Maass, Anne, Harrison, Theresa M, Landau, Susan, Baker, Suzanne, Jagust, William

“…Abstract In presymptomatic Alzheimer’s disease (AD), beta-amyloid plaques (Aβ) and tau tangles accumulate in distinct spatiotemporal patterns within the brain,…”
Get full text

Distinct effects of beta‐amyloid and tau on cortical thickness in cognitively healthy older adults by Harrison, Theresa M., Du, Richard, Klencklen, Giuliana, Baker, Suzanne L., Jagust, William J.

“…Introduction Published reports of associations between β‐amyloid (Aβ) and cortical integrity conflict. Tau biomarkers may help elucidate the complex…”
Get full text

A Link Between Cardiovascular Risk Management and Alzheimer Disease Is Still Elusive by Landau, Susan M, Harrison, Theresa M

Get more information

Regional Tau Deposition Reflects Different Pathways of Subsequent Neurodegeneration and Memory Decline in Cognitively Normal Older Adults by Chen, Xi, Toueg, Tyler N, Harrison, Theresa M, Baker, Suzanne L, Jagust, William J

“…Tau pathology is recognized as a primary contributor to neurodegeneration and clinical symptoms in Alzheimer's disease (AD). This study aims to localize the…”
Get full text

Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging by Pezzoli, Stefania, Giorgio, Joseph, Martersteck, Adam, Dobyns, Lindsey, Harrison, Theresa M., Jagust, William J.

“…INTRODUCTION There is no consensus on either the definition of successful cognitive aging (SA) or the underlying neural mechanisms. METHODS We examined the…”
Get full text

Cognitive Trajectories and Alzheimer Disease Biomarkers: From Successful Cognitive Aging to Clinical Impairment by Harrison, Theresa M., Chadwick, Trevor, Pezzoli, Stefania, Lee, JiaQie, Landau, Susan M., Jagust, William J.

“…Objective Cross‐sectional definitions of successful cognitive aging have been widely utilized, but longitudinal measurements can identify people who do not…”
Get full text

Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition by Ziontz, Jacob, Harrison, Theresa M, Chen, Xi, Giorgio, Joseph, Adams, Jenna N, Wang, Zehao, Jagust, William

“…Tau pathology is associated with cognitive impairment in both aging and Alzheimer's disease, but the functional and structural bases of this relationship…”
Get full text

Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults by Chen, Xi, Cassady, Kaitlin E, Adams, Jenna N, Harrison, Theresa M, Baker, Suzanne L, Jagust, William J

“…Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and that the presence of β-amyloid (Aβ) facilitates…”
Get full text

Effect of Alzheimer's Pathology on Task-Related Brain Network Reconfiguration in Aging by Cassady, Kaitlin E, Chen, Xi, Adams, Jenna N, Harrison, Theresa M, Zhuang, Kailin, Maass, Anne, Baker, Suzanne, Jagust, William

“…Large-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young…”
Get full text

Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function by Ziontz, Jacob, Adams, Jenna N, Harrison, Theresa M, Baker, Suzanne L, Jagust, William J

“…The mechanisms underlying accumulation of Alzheimer's disease (AD)-related tau pathology outside of the medial temporal lobe (MTL) in older adults are unknown…”
Get full text