Search Results - "Harrison, Rosemary S"

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency by Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Gómez, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni, Fairlie, David P., Klibanov, Alexander M.

“…Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic actions in vivo. However, they are expensive medicines to…”
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Restoring Australia’s long-term innovation requires investment in basic research by Harrison, Rosemary S., Barnard, Ross T., Pregelj, Lisette

“…It is well established that basic research underpins long-term innovation outputs such as transformative drugs and medical devices. However, Australia may be…”
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Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue by Ren, Guoping, Stephan, Daniel, Xu, Zhaohui, Zheng, Ying, Tang, Danming, Harrison, Rosemary S., Kurz, Mareike, Jarrott, Russell, Shouldice, Stephen R., Hiniker, Annie, Martin, Jennifer L., Heras, Begonña, Bardwell, James C.A.

“…The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play…”
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Targeting quorum sensing and competence stimulation for antimicrobial chemotherapy by Shepherd, Nicholas E, Harrison, Rosemary S, Fairlie, David P

“…Bacterial resistance to antibiotics is now a serious problem, with traditional classes of antibiotics having gradually become ineffective. New drugs are…”
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Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice by Harrison, Rosemary S, Ruiz-Gómez, Gloria, Hill, Timothy A, Chow, Shiao Y, Shepherd, Nicholas E, Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N, Fairlie, David P

“…The nociceptin opioid peptide receptor (NOP, NOR, ORL-1) is a GPCR that recognizes nociceptin, a 17-residue peptide hormone. Nociceptin regulates pain…”
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Helix Nucleation by the Smallest Known α-Helix in Water by Hoang, Huy N., Driver, Russell W., Beyer, Renée L., Hill, Timothy A., D. de Araujo, Aline, Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E., Fairlie, David P.

“…Cyclic pentapeptides (e.g. Ac‐(cyclo‐1,5)‐[KAXAD]‐NH2; X=Ala, 1; Arg, 2) in water adopt one α‐helical turn defined by three hydrogen bonds. NMR structure…”
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Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception by Lohman, Rink-Jan, Harrison, Rosemary S, Ruiz-Gómez, Gloria, Hoang, Huy N, Shepherd, Nicholas E, Chow, Shiao, Hill, Timothy A, Madala, Praveen K, Fairlie, David P

“…Nociceptin (orphanin FQ) is a 17-residue neuropeptide hormone with roles in both nociception and analgesia. It is an opioid-like peptide that binds to and…”
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Helix Nucleation by the Smallest Known α-Helix in Water by Hoang, Huy N., Driver, Russell W., Beyer, Renée L., Hill, Timothy A., D. de Araujo, Aline, Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E., Fairlie, David P.

“…Cyclic pentapeptides (e.g. Ac‐(cyclo‐1,5)‐[KAXAD]‐NH2; X=Ala, 1; Arg, 2) in water adopt one α‐helical turn defined by three hydrogen bonds. NMR structure…”
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Helix Nucleation by the Smallest Known [alpha]-Helix in Water by Hoang, Huy N, Driver, Russell W, Beyer, Renée L, Hill, Timothy A, D.deAraujo, Aline, Plisson, Fabien, Harrison, Rosemary S, Goedecke, Lena, Shepherd, Nicholas E, Fairlie, David P

“…Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X=Ala, 1; Arg, 2) in water adopt one [alpha]-helical turn defined by three hydrogen bonds. NMR structure…”
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Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding by Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Beyer, Renée L., Ruiz-Gómez, Gloria, Kelso, Michael J., Mei Kok, W., Hill, Timothy A., Abbenante, Giovanni, Fairlie, David P.

“…HIV-1 Rev is a 116 residue transporter protein that enters the host cell nucleus and uses its 17 amino acid segment (Rev34–50) to bind and capture a specific…”
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Helix Nucleation by the Smallest Known [alpha]-Helix in Water by Hoang, Huy N, Driver, Russell W, Beyer, Renée L, Hill, Timothy A, D.deAraujo, Aline, Plisson, Fabien, Harrison, Rosemary S, Goedecke, Lena, Shepherd, Nicholas E, Fairlie, David P

“…Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X=Ala, 1; Arg, 2) in water adopt one [alpha]-helical turn defined by three hydrogen bonds. NMR structure…”
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Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid ResidueS by Ren, Guoping, Stephan, Daniel, Xu, Zhaohui, Zheng, Ying, Tang, Danming, Harrison, Rosemary S., Kurz, Mareike, Jarrott, Russell, Shouldice, Stephen R., Hiniker, Annie, Martin, Jennifer L., Heras, Begoña, Bardwell, James C. A.

“…The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play…”
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