Search Results - "Harrison, Rene E"

Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages by Fu, Yan Lin, Harrison, Rene E

“…Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body…”
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In Vitro Cell Culture Model for Osteoclast Activation during Estrogen Withdrawal by Gandhi, Nisha, Omer, Safia, Harrison, Rene E

“…Estrogen (17β-estradiol) deficiency post-menopause alters bone homeostasis whereby bone resorption by osteoclasts exceeds bone formation by osteoblasts,…”
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E-cadherin is important for cell differentiation during osteoclastogenesis by Fiorino, Cara, Harrison, Rene E

“…Abstract E-cadherin, a protein responsible for intercellular adhesion between epithelial cells, is also expressed in the monocyte/macrophage lineage. In this…”
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Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion by Nabavi, Noushin, Khandani, Arian, Camirand, Anne, Harrison, Rene E

“…Abstract Exposure to microgravity has been associated with several physiological changes in astronauts, including an osteoporosis-like loss in bone mass…”
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Complement Receptor-Mediated Phagocytosis Induces Proinflammatory Cytokine Production in Murine Macrophages by Acharya, Durga, Li, Xiao Rui Lisa, Heineman, Rebecca Emily-Sue, Harrison, Rene E

“…Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and…”
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Classically Activated Macrophages Use Stable Microtubules for Matrix Metalloproteinase-9 (MMP-9) Secretion by Hanania, Raed, Song Sun, He, Xu, Kewei, Pustylnik, Sofia, Jeganathan, Sujeeve, Harrison, Rene E.

“…As major effector cells of the innate immune response, macrophages must adeptly migrate from blood to infected tissues. Endothelial transmigration is…”
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Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets by Flannagan, Ronald S., Harrison, Rene E., Yip, Christopher M., Jaqaman, Khuloud, Grinstein, Sergio

“…Binding of ligands by immunoreceptors is thought to be a passive, stochastic process. Contrary to this notion, we found that binding of IgG-opsonized particles…”
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Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli by Jeganathan, Sujeeve, Fiorino, Cara, Naik, Urja, Sun, He Song, Harrison, Rene E

“…Macrophages are generated through the differentiation of monocytes in tissues and they have important functions in innate and adaptive immunity. In addition to…”
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Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP by Harrison, Rene E., Bucci, Cecilia, Vieira, Otilia V., Schroer, Trina A., Grinstein, Sergio

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Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts by Nabavi, Noushin, Pustylnik, Sofia, Harrison, Rene E

“…Despite advances in investigating functional aspects of osteoblast (OB) differentiation, especially studies on how bone proteins are deposited and mineralized,…”
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Chlamydia trachomatis vacuole maturation in infected macrophages by Sun, He Song, Eng, Edward W. Y., Jeganathan, Sujeeve, Sin, Alex T‐W., Patel, Prerna C., Gracey, Eric, Inman, Robert D., Terebiznik, Mauricio R., Harrison, Rene E.

“…Macrophages can suppress Chlamydia replication by targeting the bacteria to degradative organelles such as lysosomes. Chlamydia trachomatis is an obligate…”
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Chlamydia trachomatis Inclusions Induce Asymmetric Cleavage Furrow Formation and Ingression Failure in Host Cells by Sun, He Song, Wilde, Andrew, Harrison, Rene E.

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Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans by Fu, Yanlin, Macwan, Vinitha, Heineman, Rebecca Emily-Sue, Terebiznik, Mauricio R., Harrison, Rene E.

“…Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages. Within an hour…”
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Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation by Touret, Nicolas, Paroutis, Paul, Terebiznik, Mauricio, Harrison, Rene E., Trombetta, Sergio, Pypaert, Marc, Chow, Amy, Jiang, Aimin, Shaw, James, Yip, Christopher, Moore, Hsiao-Ping, van der Wel, Nicole, Houben, Diane, Peters, Peter J., de Chastellier, Chantal, Mellman, Ira, Grinstein, Sergio

“…Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An…”
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Modulation of Rab5 and Rab7 Recruitment to Phagosomes by Phosphatidylinositol 3-Kinase by Vieira, Otilia V., Bucci, Cecilia, Harrison, Rene E., Trimble, William S., Lanzetti, Letizia, Gruenberg, Jean, Schreiber, Alan D., Stahl, Philip D., Grinstein, Sergio

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Terminally differentiated osteoclasts organize centrosomes into large clusters for microtubule nucleation and bone resorption by Philip, Reuben, Fiorino, Cara, Harrison, Rene E

“…Osteoclasts are highly specialized, multinucleated cells responsible for the selective resorption of the dense, calcified bone matrix. Microtubules (MTs)…”
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Methods for studying MLO-Y4 osteocytes in collagen-hydroxyapatite scaffolds in the rotary cell culture system by Fournier, Roxanne, Harrison, Rene E

“…: The rotary cell culture system (RCCS) is a common clinorotation device for cell culture. It is also used as a low-shear suspension culture bioreactor to form…”
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Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages by Omer, Safia, Li, Jiahao, Yang, Claire X, Harrison, Rene E

“…Phagocytosis by macrophages is a highly polarized process to destroy large target cells. Binding to particles induces extensive cortical actin-generated forces…”
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Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation by Patel, Prerna C., Fisher, Katherine H., Yang, Eric C.C., Deane, Charlotte M., Harrison, Rene E.

“…Classical activation of macrophages induces a wide range of signaling and vesicle trafficking events to produce a more aggressive cellular phenotype. The…”
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Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis by Botelho, Roberto J., Harrison, Rene E., Stone, James C., Hancock, John F., Philips, Mark R., Jongstra-Bilen, Jenny, Mason, David, Plumb, Jonathan, Gold, Michael R., Grinstein, Sergio

“…We describe a role for diacylglycerol in the activation of Ras and Rap1 at the phagosomal membrane. During phagocytosis, Ras density was similar on the surface…”
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