Search Results - "Harrison, RW"

A study of the effect of helium concentration and displacement damage on the microstructure of helium ion irradiated tungsten by Harrison, R.W., Greaves, G., Hinks, J.A., Donnelly, S.E.

“…Transmission electron microscopy (TEM) with in-situ He ion irradiation has been used to examine the damage microstructure of W when varying the helium…”
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On the oxidation mechanism of U3Si2 accident tolerant nuclear fuel by Harrison, R.W., Gasparrini, C., Worth, R.N., Buckley, J., Wenman, M.R., Abram, T.

“…•Intermetallic silicide compounds being pursued for accident tolerant nuclear fuels programmes globally.•Oxidation reaction and mechanisms in U3Si2 system…”
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Spark plasma sintering of (U,Ce)O2 as a MOx nuclear fuel surrogate by Harrison, R.W., Morgan, J., Buckley, J., Abram, T., Goddard, D.T., Barron, N.J.

“…•Conventional and spark plasma sintering (SPS) used to manufacture UO2 and (U, Ce)O2 pellets.•Conventional Ce-MOx had bi-modal grain size with larger grains in…”
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Atomistic level study of Ce3Si2 oxidation as an accident tolerant nuclear fuel surrogate by Harrison, R.W., Worth, R.N., Buckley, J., Abram, T.

“…•Intermetallic silicide compounds being pursued for accident tolerant nuclear fuels programmes globally.•Oxidation mechanisms in Ce-Si as a surrogate for U-Si…”
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Effect of He implantation on the microstructure of zircaloy-4 studied using in situ TEM by Tunes, M.A., Harrison, R.W., Greaves, G., Hinks, J.A., Donnelly, S.E.

“…Zirconium alloys are of great importance to the nuclear industry as they have been widely used as cladding materials in light-water reactors since the 1960s…”
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Structural defect accumulation in tungsten and tungsten-5wt.% tantalum under incremental proton damage by Ipatova, I., Harrison, R.W., Wady, P.T., Shubeita, S.M., Terentyev, D., Donnelly, S.E., Jimenez-Melero, E.

“…We have performed proton irradiation of W and W-5wt.%Ta materials at 350 °C with a step-wise damage level increase up to 0.7 dpa and using two beam energies,…”
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Local chemical instabilities in 20Cr 25Ni Nb-stabilised austenitic stainless steel induced by proton irradiation by Barcellini, C., Harrison, R.W., Dumbill, S., Donnelly, S.E., Jimenez-Melero, E.

“…We have assessed the local solute redistribution at defect sinks in 20Cr25Ni Nb-stabilised austenitic stainless steel after proton irradiation at three…”
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Characterisation of helium ion irradiated bulk tungsten: A comparison with the in-situ TEM technique by Harrison, R.W., Peng, N., Webb, R.P., Hinks, J.A., Donnelly, S.E.

“…Transmission electron microscopy (TEM) of ex-situ He ion irradiated bulk W has been performed to quantitatively compare the damage microstructure to that…”
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Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice by Barouch, Lili A, Berkowitz, Dan E, Harrison, Robert W, O'Donnell, Christopher P, Hare, Joshua M

“…Whether left ventricular hypertrophy (LVH) in obesity results from increased hemodynamic load or altered neurohormonal signaling remains controversial…”
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Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms by Hare, Joshua M, Barouch, Lili A, Harrison, Robert W, Skaf, Michel W, Rosas, Gisele O, Cappola, Thomas P, Kobeissi, Zoulficar A, Hobai, Ion A, Lemmon, Christopher A, Burnett, Arthur L, O'Rourke, Brian, Rodriguez, E. Rene, Huang, Paul L, Lima, João A. C, Berkowitz, Dan E

“…Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important regulatory mechanism for NO signalling. In the heart, NO…”
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High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains by Tie, Yunfeng, Boross, Peter I., Wang, Yuan-Fang, Gaddis, Laquasha, Hussain, Azhar K., Leshchenko, Sofiya, Ghosh, Arun K., Louis, John M., Harrison, Robert W., Weber, Irene T.

“…The compound UIC-94017 (TMC-114) is a second-generation HIV protease inhibitor with improved pharmacokinetics that is chemically related to the clinical…”
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Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M by Kovalevsky, Andrey Yu, Tie, Yunfeng, Liu, Fengling, Boross, Peter I, Wang, Yuan-Fang, Leshchenko, Sofiya, Ghosh, Arun K, Harrison, Robert W, Weber, Irene T

“…The potent new antiviral inhibitor TMC-114 (UIC-94017) of HIV-1 protease (PR) has been studied with three PR variants containing single mutations D30N, I50V,…”
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Void evolution in tungsten and tungsten-5wt.% tantalum under in-situ proton irradiation at 800 and 1000 °C by Ipatova, I., Harrison, R.W., Donnelly, S.E., Rushton, M.J.D., Middleburgh, S.C., Jimenez-Melero, E.

“…We have probed void evolution in polycrystalline W and W-5wt.%Ta material at 800 and 1000 °C, by transmission electron microscopy during in-situ irradiation…”
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Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends by Chen, Aiping, Weber, Irene T., Harrison, Robert W., Leis, Jonathan

“…A tetramer model for HIV-1 integrase (IN) with DNA representing 20 bp of the U3 and U5 long terminal repeats (LTR) termini was assembled using structural and…”
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Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling: Independent Impact of Neuronal and Endothelial Nitric Oxide Synthases by Khan, Shakil A, Skaf, Michel W, Harrison, Robert W, Lee, Kwangho, Minhas, Khalid M, Kumar, Anil, Fradley, Mike, Shoukas, Artin A, Berkowitz, Dan E, Hare, Joshua M

“…ABSTRACT—The mechanisms by which nitric oxide (NO) influences myocardial Ca cycling remain controversial. Because NO synthases (NOS) have specific spatial…”
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Geometric criteria of hydrogen bonds in proteins and identification of `bifurcated' hydrogen bonds by Torshin, Ivan Y., Weber, Irene T., Harrison, Robert W.

“…Empirical criteria for identification of hydrogen bonds were analyzed to produce a set of geometrically consistent criteria. For a data set of 30 structures,…”
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Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart by Saavedra, Walter F, Paolocci, Nazareno, St. John, Marcus E, Skaf, Michel W, Stewart, Garrick C, Xie, Jin-Sheng, Harrison, Robert W, Zeichner, Joshua, Mudrick, Daniel, Marbán, Eduardo, Kass, David A, Hare, Joshua M

“…Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an unknown mechanism. We hypothesized that this energetic effect is due to…”
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Model Structure of Decorin and Implications for Collagen Fibrillogenesis by Weber, Irene T., Harrison, Robert W., Iozzo, Renato V.

“…The three-dimensional structure of human decorin, a secreted proteoglycan involved in the regulation of collagen fibrillogenesis and cellular growth, has been…”
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Structural implications of drug-resistant mutants of HIV-1 protease: High-resolution crystal structures of the mutant protease/substrate analogue complexes by Mahalingam, Bhuvaneshwari, Louis, John M., Hung, Jason, Harrison, Robert W., Weber, Irene T.

“…Emergence of drug‐resistant mutants of HIV‐1 protease is an ongoing problem in the fight against AIDS. The mechanisms governing resistance are both complex and…”
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Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure by Ekelund, Ulf E.G, Harrison, Robert W, Shokek, Ori, Thakkar, Rajiv N, Tunin, Richard S, Senzaki, Hideaki, Kass, David A, Marbán, Eduardo, Hare, Joshua M

“…Allopurinol, an inhibitor of xanthine oxidase, increase myofilament calcium responsiveness and blunts calcium cycling in isolated cardiac muscle. We sought to…”
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