Search Results - "Harrison, Oliver J."

Thinking outside the cell: how cadherins drive adhesion by Brasch, Julia, Harrison, Oliver J, Honig, Barry, Shapiro, Lawrence

“…Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of β-sandwich extracellular cadherin (EC) domains that…”
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Structural basis of adhesive binding by desmocollins and desmogleins by Harrison, Oliver J., Brasch, Julia, Lasso, Gorka, Katsamba, Phinikoula S., Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by…”
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Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring by Lim, Ai Ing, McFadden, Taryn, Link, Verena M., Han, Seong-Ji, Karlsson, Rose-Marie, Stacy, Apollo, Farley, Taylor K., Lima-Junior, Djalma S., Harrison, Oliver J., Desai, Jigar V., Lionakis, Michail S., Shih, Han-Yu, Cameron, Heather A., Belkaid, Yasmine

“…Mom’s IL-6 rewires baby’s gut immunity Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape…”
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Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair by Linehan, Jonathan L., Harrison, Oliver J., Han, Seong-Ji, Byrd, Allyson L., Vujkovic-Cvijin, Ivan, Villarino, Alejandro V., Sen, Shurjo K., Shaik, Jahangheer, Smelkinson, Margery, Tamoutounour, Samira, Collins, Nicholas, Bouladoux, Nicolas, Dzutsev, Amiran, Rosshart, Stephan P., Arbuckle, Jesse H., Wang, Chyung-Ru, Kristie, Thomas M., Rehermann, Barbara, Trinchieri, Giorgio, Brenchley, Jason M., O’Shea, John J., Belkaid, Yasmine

“…Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the…”
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Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity by Fonseca, Denise Morais da, Hand, Timothy W., Han, Seong-Ji, Gerner, Michael Y., Zaretsky, Arielle Glatman, Byrd, Allyson L., Harrison, Oliver J., Ortiz, Alexandra M., Quinones, Mariam, Trinchieri, Giorgio, Brenchley, Jason M., Brodsky, Igor E., Germain, Ronald N., Randolph, Gwendalyn J., Belkaid, Yasmine

“…Infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the…”
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Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection by Wilhelm, Christoph, Harrison, Oliver J, Schmitt, Vanessa, Pelletier, Martin, Spencer, Sean P, Urban, Jr, Joseph F, Ploch, Michelle, Ramalingam, Thirumalai R, Siegel, Richard M, Belkaid, Yasmine

“…Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little…”
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Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins by Larsen, Ida Signe Bohse, Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Siukstaite, Lina, Harrison, Oliver J., Brasch, Julia, Goodman, Kerry M., Hansen, Lars, Shapiro, Lawrence, Honig, Barry, Vakhrushev, Sergey Y., Clausen, Henrik, Halim, Adnan

“…The cadherin (cdh) superfamily of adhesion molecules carry O-linked mannose (O-Man) glycans at highly conserved sites localized to specific β-strands of their…”
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T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine by Krausgruber, Thomas, Schiering, Chris, Adelmann, Krista, Harrison, Oliver J., Chomka, Agnieszka, Pearson, Claire, Ahern, Philip P., Shale, Matthew, Oukka, Mohamed, Powrie, Fiona

“…IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven…”
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The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins by Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry

“…Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains…”
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The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation by Kabat, Agnieszka M, Harrison, Oliver J, Riffelmacher, Thomas, Moghaddam, Amin E, Pearson, Claire F, Laing, Adam, Abeler-Dörner, Lucie, Forman, Simon P, Grencis, Richard K, Sattentau, Quentin, Simon, Anna Katharina, Pott, Johanna, Maloy, Kevin J

“…A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy…”
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Homeostatic Immunity and the Microbiota by Belkaid, Yasmine, Harrison, Oliver J.

“…The microbiota plays a fundamental role in the induction, education, and function of the host immune system. In return, the host immune system has evolved…”
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Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior by Brasch, Julia, Katsamba, Phinikoula S., Harrison, Oliver J., Ahlsén, Göran, Troyanovsky, Regina B., Indra, Indrajyoti, Kaczynska, Anna, Kaeser, Benjamin, Troyanovsky, Sergey, Honig, Barry, Shapiro, Lawrence

“…Type II cadherins are cell-cell adhesion proteins critical for tissue patterning and neuronal targeting but whose molecular binding code remains poorly…”
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Nectin ectodomain structures reveal a canonical adhesive interface by Harrison, Oliver J, Vendome, Jeremie, Brasch, Julia, Jin, Xiangshu, Hong, Soonjin, Katsamba, Phinikoula S, Ahlsen, Goran, Troyanovsky, Regina B, Troyanovsky, Sergey M, Honig, Barry, Shapiro, Lawrence

“…Nectins and nectin-like proteins promote intercellular adhesion and tissue patterning in vertebrates through homophilic or heterophilic interactions. Now the…”
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E-cadherin junction formation involves an active kinetic nucleation process by Biswas, Kabir H., Hartman, Kevin L., Yu, Cheng-han, Harrison, Oliver J., Song, Hang, Smith, Adam W., Huang, William Y. C., Lin, Wan-Chen, Guo, Zhenhuan, Padmanabhan, Anup, Troyanovsky, Sergey M., Dustin, Michael L., Shapiro, Lawrence, Honig, Barry, Zaidel-Bar, Ronen, Groves, Jay T.

“…Epithelial (E)-cadherin-mediated cell−cell junctions play important roles in the development and maintenance of tissue structure in multicellular organisms…”
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Structural and energetic determinants of adhesive binding specificity in type I cadherins by Vendome, Jeremie, Felsovalyi, Klara, Song, Hang, Yang, Zhongyu, Jin, Xiangshu, Brasch, Julia, Harrison, Oliver J., Ahlsen, Goran, Bahna, Fabiana, Kaczynska, Anna, Katsamba, Phinikoula S., Edmond, Darwin, Hubbell, Wayne L., Shapiro, Lawrence, Honig, Barry

“…Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition…”
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Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins by Harrison, Oliver J., Brasch, Julia, Katsamba, Phinikoula S., Ahlsen, Goran, Noble, Alex J., Dan, Hanbin, Sampogna, Rosemary V., Potter, Clinton S., Carragher, Bridget, Honig, Barry, Shapiro, Lawrence

“…Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural…”
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A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice by Hackstein, Carl-Philipp, Costigan, Dana, Drexhage, Linnea, Pearson, Claire, Bullers, Samuel, Ilott, Nicholas, Akther, Hossain Delowar, Gu, Yisu, FitzPatrick, Michael E. B., Harrison, Oliver J., Garner, Lucy C., Mann, Elizabeth H., Pandey, Sumeet, Friedrich, Matthias, Provine, Nicholas M., Uhlig, Holm H., Marchi, Emanuele, Powrie, Fiona, Klenerman, Paul, Thornton, Emily E.

“…Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling,…”
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Trans -endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells by Generous, Alex R, Harrison, Oliver J, Troyanovsky, Regina B, Mateo, Mathieu, Navaratnarajah, Chanakha K, Donohue, Ryan C, Pfaller, Christian K, Alekhina, Olga, Sergeeva, Alina P, Indra, Indrajyoti, Thornburg, Theresa, Kochetkova, Irina, Billadeau, Daniel D, Taylor, Matthew P, Troyanovsky, Sergey M, Honig, Barry, Shapiro, Lawrence, Cattaneo, Roberto

“…Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a…”
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Endogenous Reference Genes for Gene Expression Studies on Bicuspid Aortic Valve Associated Aortopathy in Humans by Harrison, Oliver J, Moorjani, Narain, Torrens, Christopher, Ohri, Sunil K, Cagampang, Felino R

“…Bicuspid aortic valve (BAV) disease is the most common congenital cardiac abnormality and predisposes patients to life-threatening aortic complications…”
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A cost analysis of robotic vs. video-assisted thoracic surgery: The impact of the learning curve and the COVID-19 pandemic by Harrison, Oliver J, Maraschi, Alessandro, Routledge, Tom, Lampridis, Savvas, LeReun, Corinne, Bille, Andrea

“…Robot-assisted thoracoscopic surgery (RATS) is an alternative to video-assessed thoracoscopic surgery (VATS) for the treatment of lung cancer but concern…”
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