Search Results - "Harrison, N. L."

The Size and Emergence of Geochemical Heterogeneities in the Hawaiian Mantle Plume Constrained by Sr‐Nd‐Hf Isotopic Variation Over ∼47 Million Years by L. N. Harrison, D. Weis

“…Abstract The Hawaiian‐Emperor chain is the ∼6,000 km long surface expression of the deeply sourced Hawaiian mantle plume active over the past ∼81 Myr. The…”
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Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons by Canetta, S, Bolkan, S, Padilla-Coreano, N, Song, L J, Sahn, R, Harrison, N L, Gordon, J A, Brown, A, Kellendonk, C

“…Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are…”
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Hydrothermal Activity in the Southwest Yellowstone Plateau Volcanic Field by S. Hurwitz, R. B. McCleskey, D. Bergfeld, S. E. Peek, D. D. Susong, D. A. Roth, J. D. G. Hungerford, E. B. White, L. N. Harrison, B. Hosseini, R. G. Vaughan, A. G. Hunt, J. B. Paces

“…Abstract In the past two decades, the U.S. Geological Survey and the National Park Service have studied hydrothermal activity across the Yellowstone Plateau…”
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General anaesthetic actions on ligand-gated ion channels by Krasowski, M D, Harrison, N L

“…The molecular mechanisms of general anaesthetics have remained largely obscure since their introduction into clinical practice just over 150 years ago. This…”
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Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1 by Varodayan, F.P, Pignataro, L, Harrison, N.L

“…Abstract Many synapses within the central nervous system are sensitive to ethanol. Although alcohol is known to affect the probability of neurotransmitter…”
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Methionine 286 in transmembrane domain 3 of the GABAA receptor β subunit controls a binding cavity for propofol and other alkylphenol general anesthetics by KRASOWSKI, M. D, NISHIKAWA, K, NIKOLAEVA, N, LIN, A, HARRISON, N. L

“…gamma-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis…”
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Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons by Jones, M V, Harrison, N L

“…1. The effects of the volatile anesthetics enflurane, halothane, and isoflurane on gamma-aminobutyric acid (GABA) receptor-mediated inhibitory postsynaptic…”
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GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol by Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D. F., Spigelman, I., Houser, C. R., Olsen, R. W., Harrison, N. L., Homanics, G. E.

“…The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation…”
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A subset of ventral tegmental area dopamine neurons responds to acute ethanol by Mrejeru, A, Martí-Prats, L, Avegno, E.M, Harrison, N.L, Sulzer, D

“…Highlights • Extracellular “loose-patch” recordings of neuronal activity in medial and lateral VTA cells. • A subset of DA neurons in the medial VTA were…”
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Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics by Jones, M V, Brooks, P A, Harrison, N L

“…1. The effects of the volatile anaesthetics enflurane, halothane and isoflurane on gamma-aminobutyric acid (GABA)A receptor-mediated chloride currents were…”
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On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones by Harrison, N L

“…1. (-)Baclofen reduces inhibitory postsynaptic potentials (IPSPs) and the associated synaptic currents (IPSCs) at inhibitory GABAergic synapses between…”
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Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane by Harrison, N L, Kugler, J L, Jones, M V, Greenblatt, E P, Pritchett, D B

“…The interactions of the inhalation anesthetic agent isoflurane with ligand-gated chloride channels were studied using transient expression of recombinant human…”
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Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex by Harrison, N L, Majewska, M D, Harrington, J W, Barker, J L

“…Certain steroids are potent barbiturate-like modulators of the gamma-aminobutyric acidA (GABA) receptor-chloride ionophore complex in rat brain membranes. At…”
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Steroid Hormone Metabolites are Barbiturate-Like Modulators of the GABA Receptor by Majewska, Maria Dorota, Harrison, Neil L., Schwartz, Rochelle D., Barker, Jeffery L., Paul, Steven M.

“…Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-5α-dihydroprogesterone and 3α,5α-tetrahydrodeoxycorticosterone, are…”
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Maternal immune activation does not alter the number of perisomatic parvalbumin-positive boutons in the offspring prefrontal cortex by Canetta, S, Bolkan, S, Padilla-Coreano, N, Song, L J, Sahn, R, Harrison, N L, Gordon, J A, Brown, A, Kellendonk, C

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Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2 by Bloomenthal, A B, Goldwater, E, Pritchett, D B, Harrison, N L

“…The effects of extracellular applications of Zn2+ ions on the strychnine-sensitive glycine receptor were studied in cultured rat spinal cord neurons and with…”
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Quantitative studies on some antagonists of N‐methyl D‐aspartate in slices of rat cerebral cortex by Harrison, Neil L., Simmonds, Michael A.

“…1 Coronal sections of rat brain (500 μm thick) were trimmed to form ‘wedges’ of tissue consisting of cerebral cortex and corpus callosum. 2 When these slices…”
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Ion channels take center stage: twin spotlights on two anesthetic targets by Harrison, N L

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On the mechanism of modulation of transient outward current in cultured rat hippocampal neurons by di- and trivalent cations by Talukder, G, Harrison, N L

“…1. The mechanisms of Zn2+ modulation of transient outward current (TOC) were studied in cultured rat hippocampal neurons, using the voltage-clamp technique. In…”
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Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice by Perrier, Anselme L, Topf, Norbert, Barberi, Tiziano, Rubio, Maria E, Calingasan, Noel Y, Bruses, Juan, Studer, Lorenz, Klivenyi, Peter, Beal, M Flint, Moore, Malcolm A S, Kawamata, Hibiki, Harrison, Neil L, Lee, Hyojin, Loonam, Kathleen, Tabar, Viviane

“…Existing protocols for the neural differentiation of mouse embryonic stem (ES) cells require extended in vitro culture, yield variable differentiation results…”
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