Search Results - "Harrison, Michael A"

Structural divergence of the rotary ATPases by Muench, Stephen P, Trinick, John, Harrison, Michael A

“…The rotary ATPase family of membrane protein complexes may have only three members, but each one plays a fundamental role in biological energy conversion. The…”
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Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy by Shaik, Faheem, Cuthbert, Gary A, Homer-Vanniasinkam, Shervanthi, Muench, Stephen P, Ponnambalam, Sreenivasan, Harrison, Michael A

“…Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety of cells to regulate diverse biological responses. The VEGF-A family…”
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Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes by Smith, Gina A., Howell, Gareth J., Phillips, Clair, Muench, Stephen P., Ponnambalam, Sreenivasan, Harrison, Michael A.

“…Plasma membrane vacuolar H+-ATPase (V-ATPase) activity of tumor cells is a major factor in control of cytoplasmic and extracellular pH and metastatic…”
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The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis by Smith, Gina A, Fearnley, Gareth W, Tomlinson, Darren C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…VEGFs (vascular endothelial growth factors) are a family of conserved disulfide-linked soluble secretory glycoproteins found in higher eukaryotes. VEGFs…”
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Structure of the Vacuolar H+-ATPase Rotary Motor Reveals New Mechanistic Insights by Rawson, Shaun, Phillips, Clair, Huss, Markus, Tiburcy, Felix, Wieczorek, Helmut, Trinick, John, Harrison, Michael A., Muench, Stephen P.

“…Vacuolar H+-ATPases are multisubunit complexes that operate with rotary mechanics and are essential for membrane proton transport throughout eukaryotes. Here…”
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VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8 by Smith, Gina A., Fearnley, Gareth W., Abdul‐Zani, Izma, Wheatcroft, Stephen B., Tomlinson, Darren C., Harrison, Michael A., Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor A (VEGF‐A) regulates many aspects of vascular function. VEGF‐A binding to vascular endothelial growth factor receptor 2…”
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Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease by Cuthbert, Gary A, Shaik, Faheem, Harrison, Michael A, Ponnambalam, Sreenivasan, Homer-Vanniasinkam, Shervanthi

“…The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its…”
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Cryo-electron Microscopy of the Vacuolar ATPase Motor Reveals its Mechanical and Regulatory Complexity by Muench, Stephen P., Huss, Markus, Song, Chun Feng, Phillips, Clair, Wieczorek, Helmut, Trinick, John, Harrison, Michael A.

“…The vacuolar H +-ATPase (V-ATPase) is an ATP-driven rotary molecular motor that is a transmembrane proton pump in all eukaryotic cells. Although its activity…”
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Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking by Critchley, William R, Pellet-Many, Caroline, Ringham-Terry, Benjamin, Harrison, Michael A, Zachary, Ian C, Ponnambalam, Sreenivasan

“…Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that…”
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Flexibility within the rotor and stators of the vacuolar H+-ATPase by Song, Chun Feng, Papachristos, Kostas, Rawson, Shaun, Huss, Markus, Wieczorek, Helmut, Paci, Emanuele, Trinick, John, Harrison, Michael A, Muench, Stephen P

“…The V-ATPase is a membrane-bound protein complex which pumps protons across the membrane to generate a large proton motive force through the coupling of an…”
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VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis by Fearnley, Gareth W, Smith, Gina A, Abdul-Zani, Izma, Yuldasheva, Nadira, Mughal, Nadeem A, Homer-Vanniasinkam, Shervanthi, Kearney, Mark T, Zachary, Ian C, Tomlinson, Darren C, Harrison, Michael A, Wheatcroft, Stephen B, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate…”
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Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function by Smith, Gina A, Fearnley, Gareth W, Abdul-Zani, Izma, Wheatcroft, Stephen B, Tomlinson, Darren C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined…”
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In-silico prediction, characterization, molecular docking and dynamic simulation studies for screening potential fungicides against leaf rust of Triticum aestivum by Gosavi, Gokul, Jade, Dhananjay, Ponnambalam, Sreenivasan, Harrison, Michael A., Zhou, Huanbin

“…Triticum aestivum is an important crop worldwide, which is a large source of food grain. T.aestivum demands on developed countries will grow every year, this…”
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The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function by Critchley, William R, Smith, Gina A, Zachary, Ian C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that…”
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E2 ubiquitin-conjugating enzymes, UBE2D1 and UBE2D2, regulate VEGFR2 dynamics and endothelial function by Critchley, William R, Smith, Gina A, Zachary, Ian C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor receptor 2 (VEGFR2) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination which programs this…”
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Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening by Jade, Dhananjay, Alzahrani, Areej, Critchley, William, Ponnambalam, Sreenivasan, Harrison, Michael A.

“…The SARS-CoV-2 coronavirus is responsible for the COVID-19 outbreak, which overwhelmed millions of people worldwide; hence, there is an urgency to identify…”
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Receptor tyrosine kinase structure and function in health and disease by A. Karpov, Oleg, W. Fearnley, Gareth, A. Smith, Gina, Kankanala, Jayakanth, J. McPherson, Michael, C. Tomlinson, Darren, A. Harrison, Michael, Ponnambalam, Sreenivasan

“…Receptor tyrosine kinases (RTKs) are membrane proteins that control the flow of information through signal transduction pathways, impacting on different…”
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“Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation by Roper, Barnaby W.R., Tiede, Christian, Abdul-Zani, Izma, Cuthbert, Gary A., Jade, Dhananjay, Al-Aufi, Ahmed, Critchley, William R., Saikia, Queen, Homer-Vanniasinkam, Shervanthi, Sawamura, Tatsuya, McPherson, Michael J., Harrison, Michael A., Tomlinson, Darren C., Ponnambalam, Sreenivasan

“…In multicellular organisms, a variety of lipid-protein particles control the systemic flow of triacylglycerides, cholesterol, and fatty acids between cells in…”
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Virtual high throughput screening of natural peptides against ErbB1 and ErbB2 to identify potential inhibitors for cancer chemotherapy by Patnaik, Sunil Kumar, Ayyamperumal, Selvaraj, Jade, Dhananjay, Palathoti, Nagarjuna, Akey, Krishna Swaroop, Jupudi, Srikanth, Harrison, Michael A., Ponnambalam, Sreenivasan, MJ, Nanjan, MJN, Chandrasekar

“…Human epidermal growth factor receptors (EGFR), namely ErbB1/HER1, ErbB2/HER2/neu, ErbB3/HER3, and ErbB4/HER4, the trans-membrane family of tyrosine kinase…”
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A research‐led flexible cell biology practical for biological sciences undergraduate and postgraduate degree courses by Divan, Aysha, Alzahrani, Areej, Shaik, Faheem, Mitchell, Joanna, Harrison, Michael A., Odell, Adam, Ponnambalam, Sreenivasan

“…A challenge in the pandemic era is to implement effective but flexible practical teaching for biological sciences courses. Such teaching needs to deliver…”
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