Search Results - "Harrison, Justin"

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis by Wang, Qinglan, Boshoff, Helena I M, Harrison, Justin R, Ray, Peter C, Green, Simon R, Wyatt, Paul G, Barry, 3rd, Clifton E

“…has an unusual outer membrane that lacks canonical porin proteins for the transport of small solutes to the periplasm. We discovered that 3,3-…”
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Progress in high-power and high-intensity structured light by Harrison, Justin, Naidoo, Darryl, Forbes, Andrew, Dudley, Angela

“…ABSTRACTStructured light refers to the ability to tailor light in its many degrees of freedom, from the traditional control in time and space to more exotic…”
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The Blood of Goats and Calves … and Bulls? An Allusion to Isaiah 1:11 LXX in Hebrews 10:4 by Duff, Justin Harrison

“…Hebrews 9:12-10:4 characterizes the blood of the first covenant in four ways: as the blood of goats and calves (9:12), as the blood of goats and bulls (9:13),…”
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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors by Harrison, Justin R, Brand, Stephen, Smith, Victoria, Robinson, David A, Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S, Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C, Stojanovski, Laste, Frearson, Julie A, Brenk, Ruth, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D

“…Crystallography has guided the hybridization of two series of Trypanosoma brucei N-myristoyltransferase (NMT) inhibitors, leading to a novel highly selective…”
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Bathymetric evolution of Tasman Glacier terminal lake, New Zealand, as determined by remote surveying techniques by Purdie, Heather, Bealing, Paul, Tidey, Emily, Gomez, Christopher, Harrison, Justin

“…Processes that drive iceberg calving at the margins of freshwater terminating glaciers are still poorly understood. This knowledge-gap is in part due to the…”
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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease by Harrison, Justin R, Sarkar, Sandipan, Hampton, Shahienaz, Riley, Jennifer, Stojanovski, Laste, Sahlberg, Christer, Appelqvist, Pia, Erath, Jessey, Mathan, Vinodhini, Rodriguez, Ana, Kaiser, Marcel, Pacanowska, Dolores Gonzalez, Read, Kevin D, Johansson, Nils Gunnar, Gilbert, Ian H

“…Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of…”
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The Blood of Goats and Calves … and Bulls? An Allusion to Isaiah 1:11 LXX in Hebrews 10:4 by Duff, Justin Harrison

“…Hebrews 9:12–10:4 characterizes the blood of the first covenant in four ways: as the blood of goats and calves (9:12), as the blood of goats and bulls (9:13),…”
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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis by Smith, Alasdair, Wall, Richard J, Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E, Thomas, Michael G, Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S, Harrison, Justin R, Milne, Rachel, Jeacock, Laura, Baker, Nicola, Davis, Susan H, Simeons, Frederick, Riley, Jennifer, Horn, David, Brun, Reto, Zuccotto, Fabio, Witty, Michael J, Wyllie, Susan, Read, Kevin D, Gilbert, Ian H

“…African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites Trypanosoma congolense and Trypanosoma vivax , is a major…”
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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis by Brand, Stephen, Norcross, Neil R, Thompson, Stephen, Harrison, Justin R, Smith, Victoria C, Robinson, David A, Torrie, Leah S, McElroy, Stuart P, Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C, van Aalten, Daan, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael A. J, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D

“…Trypanosoma brucei N-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis (HAT). From previous…”
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Give me strength or give me a reason: self-control, religion, and the currency of reputation by Harrison, Justin M D, McKay, Ryan

“…We show that Kurzban et al.'s approach illuminates the relationship between religion and self-control. Whereas resource-depletion theorists suggest religion…”
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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors by Brand, Stephen, Cleghorn, Laura A. T, McElroy, Stuart P, Robinson, David A, Smith, Victoria C, Hallyburton, Irene, Harrison, Justin R, Norcross, Neil R, Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael A. J, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H

“…N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma…”
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N‑Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus by Fang, Wenxia, Robinson, David A, Raimi, Olawale G, Blair, David E, Harrison, Justin R, Lockhart, Deborah E. A, Torrie, Leah S, Ruda, Gian Filippo, Wyatt, Paul G, Gilbert, Ian H, van Aalten, Daan M. F

“…Treatment of filamentous fungal infections relies on a limited repertoire of antifungal agents. Compounds possessing novel modes of action are urgently…”
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Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS by Torrie, Leah S, Wyllie, Susan, Spinks, Daniel, Oza, Sandra L, Thompson, Stephen, Harrison, Justin R, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H, Frearson, Julie A

“…In the search for new therapeutics for the treatment of human African trypanosomiasis, many potential drug targets in Trypanosoma brucei have been validated by…”
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2‑Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization by Murugesan, Dinakaran, Ray, Peter C., Bayliss, Tracy, Prosser, Gareth A., Harrison, Justin R., Green, Kirsteen, Soares de Melo, Candice, Feng, Tzu-Shean, Street, Leslie J., Chibale, Kelly, Warner, Digby F., Mizrahi, Valerie, Epemolu, Ola, Scullion, Paul, Ellis, Lucy, Riley, Jennifer, Shishikura, Yoko, Ferguson, Liam, Osuna-Cabello, Maria, Read, Kevin D., Green, Simon R., Lamprecht, Dirk A., Finin, Peter M., Steyn, Adrie J. C., Ioerger, Thomas R., Sacchettini, Jim, Rhee, Kyu Y., Arora, Kriti, Barry, Clifton E., Wyatt, Paul G., Boshoff, Helena I. M.

“…Mycobacterium tuberculosis (MTb) possesses two nonproton pumping type II NADH dehydrogenase (NDH-2) enzymes which are predicted to be jointly essential for…”
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Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi by Herrera, Linda J, Brand, Stephen, Santos, Andres, Nohara, Lilian L, Harrison, Justin, Norcross, Neil R, Thompson, Stephen, Smith, Victoria, Lema, Carolina, Varela-Ramirez, Armando, Gilbert, Ian H, Almeida, Igor C, Maldonado, Rosa A

“…Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected…”
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Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors by Spinks, Daniel, Torrie, Leah S., Thompson, Stephen, Harrison, Justin R., Frearson, Julie A., Read, Kevin D., Fairlamb, Alan H., Wyatt, Paul G., Gilbert, Ian H.

“…Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis. It is…”
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Winter comparison of TEOM, MiniVol and DustTrak PM10 monitors in a woodsmoke environment by KINGHAM, Simon, DURAND, Michael, ABERKANE, Teresa, HARRISON, Justin, WILSON, J. Gaines, EPTON, Michael

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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis by Brand, Stephen, Norcross, Neil R, Thompson, Stephen, Harrison, Justin R, Smith, Victoria C, Robinson, David A, Torrie, Leah S, McElroy, Stuart P, Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick RC, van Aalten, Daan, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael AJ, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D

“…Trypanosoma bruceiN-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis (HAT). From previous…”
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A Concise Synthesis of the Octalactins by O'Sullivan, Paul T, Buhr, Wilm, Fuhry, Mary Ann M, Harrison, Justin R, Davies, John E, Feeder, Neil, Marshall, David R, Burton, Jonathan W, Holmes, Andrew B

“…The total synthesis of octalactins A and B has been achieved in 15 steps (longest linear sequence) and 10% overall yield from commercially available materials…”
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Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia by Jovanovic, Jelena V, Rennie, Kristian, Culligan, Dominic, Peniket, Andrew, Lennard, Anne, Harrison, Justin, Vyas, Paresh, Grimwade, David

“…Molecular detection of minimal residual disease (MRD) has become established to assess remission status and guide therapy in patients with ProMyelocytic…”
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