Search Results - "Harrison, Julian A"

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes by Ledsgaard, Line, Wade, Jack, Jenkins, Timothy P., Boddum, Kim, Oganesyan, Irina, Harrison, Julian A., Villar, Pedro, Leah, Rachael A., Zenobi, Renato, Schoffelen, Sanne, Voldborg, Bjørn, Ljungars, Anne, McCafferty, John, Lomonte, Bruno, Gutiérrez, José M., Laustsen, Andreas H., Karatt-Vellatt, Aneesh

“…Snakebite envenoming continues to claim many lives across the globe, necessitating the development of improved therapies. To this end, broadly-neutralizing…”
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Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data by Wu, Ri, Metternich, Jonas B., Kamenik, Anna S., Tiwari, Prince, Harrison, Julian A., Kessen, Dennis, Akay, Hasan, Benzenberg, Lukas R., Chan, T.-W. Dominic, Riniker, Sereina, Zenobi, Renato

“…Mass spectrometry is a powerful technique for the structural and functional characterization of biomolecules. However, it remains challenging to accurately…”
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Conformational Dynamics of Hemoglobin in Solution and the Gas Phase Elucidated by Mass Spectrometry by Harrison, Julian A., Gabriel, Janic, Pruška, Adam, Zenobi, Renato

“…Solution and gas-phase measurements can provide valuable insights into biomolecular conformational dynamics. By comparing the data from such experiments, it is…”
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Mass spectrometry data and size exclusion chromatography profiles of Australian taipan venom toxins by Harrison, Julian A., Aquilina, J. Andrew

“…The compositions of paradoxin and taipoxin (PDx and TPx, respectively) were investigated using size exclusion chromatography (SEC) and nano-electrospray…”
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Exploring Gas-Phase MS Methodologies for Structural Elucidation of Branched N‑Glycan Isomers by Oganesyan, Irina, Hajduk, Joanna, Harrison, Julian A., Marchand, Adrien, Czar, Martin F., Zenobi, Renato

“…Structural isomers of N-glycans that are identical in mass and atomic composition provide a great challenge to conventional mass spectrometry (MS). This study…”
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Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation by Pruška, Adam, Harrison, Julian A., Granzhan, Anton, Marchand, Adrien, Zenobi, Renato

“…DNA three-way junction (TWJ) structures transiently form during key cellular processes such as transcription, replication, and DNA repair. Despite their…”
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Continuous Electrospray Ionization Mass Spectrometry Assay for Measuring Phospholipase Activity against Liposomes by Harrison, Julian A., Kelso, Celine, Beck, Jennifer L.

“…Phospholipases have diverse roles in lipid and cell membrane biology. In animal venoms, they can have roles as neurotoxins or myotoxins that disrupt the…”
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Advancing Cyclic Ion Mobility Mass Spectrometry Methods for Studying Biomolecules: Toward the Conformational Dynamics of Mega Dalton Protein Aggregates by Harrison, Julian A., Pruška, Adam, Bittner, Philipp, Muck, Alexander, Cooper-Shepherd, Dale A., Zenobi, Renato

“…Native mass spectrometry is a powerful tool for the analysis of noncovalent complexes. When coupled with high-resolution ion mobility, this technique can be…”
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Streamlining the Analysis of Proteins from Snake Venom by Oganesyan, Irina, Jenkins, Timothy P., Laustsen, Andreas H., Zenobi, Renato, Harrison, Julian A.

“…Investigating snake venom is necessary for developing new treatments for envenoming and harnessing the therapeutic potential that lies within venom toxins…”
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Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS by Harrison, Julian A., Kelso, Celine, Pukala, Tara L., Beck, Jennifer L.

“…Determination of collisional cross sections (CCS) by travelling wave ion mobility mass spectrometry (TWIM-MS) requires calibration against standards for which…”
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Structural Studies of a Stapled Peptide with Native Ion Mobility-Mass Spectrometry and Transition Metal Ion Förster Resonance Energy Transfer in the Gas Phase by Wu, Ri, Metternich, Jonas B., Tiwari, Prince, Benzenberg, Lukas R., Harrison, Julian A., Liu, Qinlei, Zenobi, Renato

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Prototyping of a lateral flow assay based on monoclonal antibodies for detection of Bothrops venoms by Knudsen, Cecilie, Jürgensen, Jonas A., D. Knudsen, Pelle, Oganesyan, Irina, Harrison, Julian A., Dam, Søren H., Haack, Aleksander M., Friis, Rasmus U.W., Vitved, Lars, Belfakir, Selma B., Ross, Georgina M.S., Zenobi, Renato, H. Laustsen, Andreas

“…Brazil is home to a multitude of venomous snakes; perhaps the most medically relevant of which belong to the Bothrops genus. Bothrops spp. are responsible for…”
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Insights into the subunit arrangement and diversity of paradoxin and taipoxin by Harrison, Julian A., Aquilina, J. Andrew

“…Paradoxin and taipoxin are neurotoxic phospholipases from the inland and coastal species of Australian taipan. Despite their relatively high sequence homology…”
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Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation by McAlary, Luke, Harrison, Julian A, Aquilina, J. Andrew, Fitzgerald, Steven P, Kelso, Celine, Benesch, Justin L.P, Yerbury, Justin J

“…Native mass spectrometry (MS) is a powerful means for studying macromolecular protein assemblies, including accessing activated states. However, much remains…”
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Stoichiometry and architecture of the human pyruvate dehydrogenase complex by Zdanowicz, Rafal, Afanasyev, Pavel, Pruška, Adam, Harrison, Julian A, Giese, Christoph, Boehringer, Daniel, Leitner, Alexander, Zenobi, Renato, Glockshuber, Rudi

“…The pyruvate dehydrogenase complex (PDHc) is a key megaenzyme linking glycolysis with the citric acid cycle. In mammalian PDHc, dihydrolipoamide…”
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Structural Studies of a Stapled Peptide with Native Ion Mobility-Mass Spectrometry and Transition Metal Ion Förster Resonance Energy Transfer in the Gas Phase by Wu, Ri, Metternich, Jonas B., Tiwari, Prince, Benzenberg, Lukas R., Harrison, Julian A., Liu, Qinlei, Zenobi, Renato

“…Native mass spectrometry has emerged as an important tool for gas-phase structural biology. However, the conformations that a biomolecular ion adopts in the…”
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Structural characterization of protein toxins from Australian snake venoms using native mass spectrometry by Harrison, Julian A., Kelso, Celine, Padula, Matthew P., Nicholson, Graham M., Beck, Jennifer L.

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