Search Results - "Harrison, Jacob C"

Surviving the breakup: the DNA damage checkpoint by Harrison, Jacob C, Haber, James E

“…In response to even a single chromosomal double-strand DNA break, cells enact the DNA damage checkpoint. This checkpoint triggers cell cycle arrest, providing…”
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DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase by Dotiwala, Farokh, Eapen, Vinay V, Harrison, Jacob C, Arbel-Eden, Ayelet, Ranade, Vikram, Yoshida, Satoshi, Haber, James E

“…Budding yeast cells suffering a single unrepaired double-strand break (DSB) trigger the Mec1 (ATR)-dependent DNA damage response that causes them to arrest…”
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Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism by Dotiwala, Farokh, Harrison, Jacob C., Jain, Suvi, Sugawara, Neal, Haber, James E.

“…Eukaryotic cells employ a suite of replication and mitotic checkpoints to ensure the accurate transmission of their DNA. In budding yeast, both the DNA damage…”
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Anaplerotic Role for Cytosolic Malic Enzyme in Engineered Saccharomyces cerevisiae Strains by Zelle, Rintze M, Harrison, Jacob C, Pronk, Jack T, van Maris, Antonius J.A

“…Malic enzyme catalyzes the reversible oxidative decarboxylation of malate to pyruvate and CO₂. The Saccharomyces cerevisiae MAE1 gene encodes a mitochondrial…”
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Phosphoenolpyruvate Carboxykinase as the Sole Anaplerotic Enzyme in Saccharomyces cerevisiae by Zelle, Rintze M, Trueheart, Josh, Harrison, Jacob C, Pronk, Jack T, van Maris, Antonius J.A

“…Pyruvate carboxylase is the sole anaplerotic enzyme in glucose-grown cultures of wild-type Saccharomyces cerevisiae. Pyruvate carboxylase-negative (Pyc⁻) S…”
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Stress-specific Activation Mechanisms for the “Cell Integrity” MAPK Pathway by Harrison, Jacob C., Zyla, Trevin R., Bardes, Elaine S.G., Lew, Daniel J.

“…Many environmental stresses trigger cellular responses by activating mitogen-activated protein kinase (MAPK) pathways. Once activated, these highly conserved…”
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A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint by Lew, Daniel J, Harrison, Jacob C, Bardes, Elaine S.G, Ohya, Yoshikazu

“…In many cells the timing of entry into mitosis is controlled by the balance between the activity of inhibitory Wee1-related kinases (Swe1p in budding yeast)…”
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A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery by Lieberman, Judy, Keogh, Michael-Christopher, Downey, Michael, Chowdhury, Dipanjan, Datta, Nira, Harrison, Jacob C, Emili, Andrew, Haber, James E, Krogan, Nevan J, Durocher, Daniel, Fillingham, Jeffrey, Greenblatt, Jack F, Galicia, Sarah, Shen, Xuetong, Buratowski, Stephen, Kim, Jung-Ae, Onishi, Megumi

“…One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif…”
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Functional Interactions Between Sae2 and the Mre11 Complex by Kim, Hee-Sook, Vijayakumar, Sangeetha, Reger, Mike, Harrison, Jacob C, Haber, James E, Weil, Clifford, Petrini, John H. J

“…The Mre11 complex functions in double-strand break (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways. Sae2 deficiency has opposing…”
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Determinants of Swe1p degradation in Saccharomyces cerevisiae by McMillan, John N, Theesfeld, Chandra L, Harrison, Jacob C, Bardes, Elaine S G, Lew, Daniel J

“…Swe1p, the sole Wee1-family kinase in Saccharomyces cerevisiae, is synthesized during late G1 and is then degraded as cells proceed through the cell cycle…”
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The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint by Marquitz, Aron R., Harrison, Jacob C., Bose, Indrani, Zyla, Trevin R., McMillan, John N., Lew, Daniel J.

“…The Saccharomyces cerevisiae morphogenesis checkpoint delays mitosis in response to insults that impair actin organization and/or bud formation. The delay is…”
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The DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase by Eapen, Vinay Verghese, Dotiwala, Farokh J, Harrison, Jacob C, Eden, Ayelet A, Ranade, Vikram, Yoshida, Satoshi, Haber, James E

“…Abstract only Budding yeast cells suffering a single, unrepaired DNA double strand break (DSB) arrest prior to anaphase for 12–15 h, in a Mec1 (ATR)‐dependent…”
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DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase by Dotiwala, Farokh, Eapen, Vinay V., Harrison, Jacob C., Arbel-Eden, Ayelet, Ranade, Vikram, Yoshida, Satoshi, Haber, James E.

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Phosphoenolpyruvate Carboxykinase as the Sole Anaplerotic Enzyme in Saccharomvces cerevisiae by ZELLE, Rintze M, TRUEHEART, Josh, HARRISON, Jacob C, PRONK, Jack T, VAN MARIS, Antonius J. A

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Stress-specific Activation Mechanisms for the “Cell Integrity” MAPK Pathway by Jacob C. Harrison, Trevin R. Zyla, Elaine S. G. Bardes, Daniel J. Lew

“…Many environmental stresses trigger cellular responses by activating mitogen-activated protein kinase (MAPK) pathways. Once activated, these highly conserved…”
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Corrigendum: A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery by Keogh, Michael-Christopher, Kim, Jung-Ae, Downey, Michael, Fillingham, Jeffrey, Chowdhury, Dipanjan, Harrison, Jacob C, Onishi, Megumi, Datta, Nira, Galicia, Sarah, Emili, Andrew, Lieberman, Judy, Shen, Xuetong, Buratowski, Stephen, Haber, James E, Durocher, Daniel, Greenblatt, Jack F, Krogan, Nevan J

“…Corrigendum: A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery…”
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Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery by Keogh, Michael-Christopher, Kim, Jung-Ae, Downey, Michael, Fillingham, Jeffrey, Chowdhury, Dipanjan, Harrison, Jacob C, Onishi, Megumi, Datta, Nira, Galicia, Sarah, Emili, Andrew, Lieberman, Judy, Shen, Xuetong, Buratowski, Stephen, Haber, James E, Durocher, Daniel, Greenblatt, Jack F, Krogan, Nevan J

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Corrigendum: A phosphatase complex that dephosphorylates [gamma]H2AX regulates DNA damage checkpoint recovery by Michael-Christopher Keogh, Jung-Ae, Kim, Downey, Michael, Fillingham, Jeffrey, Chowdhury, Dipanjan, Harrison, Jacob C, Onishi, Megumi, Datta, Nira, Galicia, Sarah, Emili, Andrew, Lieberman, Judy, Shen, Xuetong, Buratowski, Stephen, Haber, James E, Durocher, Daniel

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Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery by Keogh, Michael-Christopher, Kim, Jung-Ae, Downey, Michael, Fillingham, Jeffrey, Chowdhury, Dipanjan, Harrison, Jacob C., Onishi, Megumi, Datta, Nira, Galicia, Sarah, Emili, Andrew, Lieberman, Judy, Shen, Xuetong, Buratowski, Stephen, Haber, James E., Durocher, Daniel, Greenblatt, Jack F., Krogan, Nevan J.

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery by Keogh, Michael-Christopher, Kim, Jung-Ae, Downey, Michael, Fillingham, Jeffrey, Chowdhury, Dipanjan, Harrison, Jacob C, Onishi, Megumi, Datta, Nira, Galicia, Sarah, Emili, Andrew, Lieberman, Judy, Shen, Xuetong, Buratowski, Stephen, Haber, James E, Durocher, Daniel, Greenblatt, Jack F, Krogan, Nevan J

“…One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif…”
Get full text