Search Results - "Harrison, G D"

Hope for resistant hypertension through BrigHTN and PRECISION by Touyz, R. M., Harrison, D. G.

“…An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings from two new clinical trials — BrigHTN and…”
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Endothelial mechanotransduction, nitric oxide and vascular inflammation by HARRISON, D. G., WIDDER, J., GRUMBACH, I., CHEN, W., WEBER, M., SEARLES, C.

“… Numerous aspects of vascular homeostasis are modulated by nitric oxide and reactive oxygen species (ROS). The production of these is dramatically influenced…”
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Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus by Hink, Ulrich, Li, Huige, Mollnau, Hanke, Oelze, Mathias, Matheis, Edi, Hartmann, Mark, Skatchkov, Mikhail, Thaiss, Friedrich, Stahl, Rolf A.K, Warnholtz, Ascan, Meinertz, Thomas, Griendling, Kathy, Harrison, David G, Forstermann, Ulrich, Munzel, Thomas

“…ABSTRACT —Incubation of endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase…”
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Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress by Uematsu, M, Ohara, Y, Navas, J P, Nishida, K, Murphy, T J, Alexander, R W, Nerem, R M, Harrison, D G

“…Shear stress enhances expression of Ca(2+)-calmodulin-sensitive endothelial cell nitric oxide synthase (ecNOS) mRNA and protein in bovine aortic endothelial…”
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Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension by Bersi, M. R., Khosravi, R., Wujciak, A. J., Harrison, D. G., Humphrey, J. D.

“…The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads…”
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Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone by Rajagopalan, S, Kurz, S, Münzel, T, Tarpey, M, Freeman, B A, Griendling, K K, Harrison, D G

“…We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase…”
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Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis : Evidence for involvement of the renin-angiotensin system by WARNHOLTZ, A, NICKENIG, G, BÖHM, M, MEINERTZ, T, MÜNZEL, T, SCHULZ, E, MACHARZINA, R, BRÄSEN, J. H, SKATCHKOV, M, HEITZER, T, STASCH, J. P, GRIENDLING, K. K, HARRISON, D. G

“…Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is…”
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Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide by Drummond, Grant R, Cai, Hua, Davis, Michael E, Ramasamy, Santhini, Harrison, David G

“…ABSTRACTDiverse stimuli, including shear stress, cyclic strain, oxidized LDL, hyperglycemia, and cell growth, modulate endothelial nitric oxide synthase (eNOS)…”
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Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension by LAURSEN, J. B, RAJAGOPALAN, S, GALIS, Z, TARPEY, M, FREEMAN, B. A, HARRISON, D. G

“…The major source of superoxide (.O2-) in vascular tissues is an NADH/NADPH-dependent, membrane-bound oxidase. We have previously shown that this oxidase is…”
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Cellular and molecular mechanisms of endothelial cell dysfunction by Harrison, D G

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Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt by SOMERS, M. J, MAVROMATIS, K, GALIS, Z. S, HARRISON, D. G

“…Angiotensin II-induced hypertension is associated with increased vascular superoxide production, which contributes to hypertension caused by the octapeptide…”
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Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy by ZAFARI, A. M, USHIO-FUKAI, M, AKERS, M, QIQIN YIN, SHAH, A, HARRISON, D. G, TAYLOR, W. R, GRIENDLING, K. K

“…Recent evidence suggests that oxidative mechanisms may be involved in vascular smooth muscle cell (VSMC) hypertrophy. We previously showed that angiotensin II…”
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Hypercholesterolemia increases endothelial superoxide anion production by OHARA, Y, PETERSON, T. E, HARRISON, D. G

“…Indirect evidence suggests accelerated degradation of endothelium-derived nitric oxide (ENDO) by superoxide anion (O2-) in hypercholesterolemic vessels (HV)…”
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Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature : A potential link between the renin-angiotensin system and atherosclerosis by TUMMALA, P. E, CHEN, X.-L, SUNDELL, C. L, LAURSEN, J. B, HAMMES, C. P, ALEXANDER, R. W, HARRISON, D. G, MEDFORD, R. M

“…Cardiovascular ischemic events may occur more frequently in hypertensive patients with activated renin-angiotensin systems. We tested the hypothesis that…”
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Macrophages come to mind as keys to cognitive decline by Harrison, D G, Guzik, Tomasz J

“…Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by…”
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The nitrovasodilators : new ideas about old drugs by HARRISON, D. G, BATES, J. N

“…The nitrovasodilators are a diverse group of pharmacological agents that produce vascular relaxation by releasing nitric oxide. The mechanisms by which these…”
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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats by Harrison, D G, Bader, M, Lerman, L O, Fink, G, Karumanchi, S A, Reckelhoff, J F, Sequeira-Lopez, M L S, Touyz, R M

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Nitric Oxide Regulates Vascular Cell Adhesion Molecule 1 Gene Expression and Redox-Sensitive Transcriptional Events in Human Vascular Endothelial Cells by Khan, Bobby V., Harrison, David G., Olbrych, Matthew T., Alexander, R. Wayne, Medford, Russell M.

“…Decreased nitric oxide (NO) activity, the formation of reactive oxygen species, and increased endothelial expression of the redox-sensitive vascular cell…”
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Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels by Wilcox, Josiah N, Subramanian, Romesh R, Sundell, Cynthia L, Tracey, W. Ross, Pollock, Jennifer S, Harrison, David G, Marsden, Philip A

“…Atherosclerosis is associated with reduced endothelium-derived relaxing factor bioactivity. To determine whether this is due to decreased synthesis of nitric…”
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p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats by Fukui, Toshiki, Ishizaka, Nobukazu, Rajagopalan, Sanjay, Laursen, Jorn Bech, Capers, Quinn, Taylor, W. Robert, Harrison, David G, de Leon, Hector, Wilcox, Josiah N, Griendling, Kathy K

“…Recent studies suggest that superoxide production by the NADPH/NADH oxidase may be involved in smooth muscle cell growth and the pathogenesis of hypertension…”
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