Search Results - "Harris, Tyler L."

Glycation Reactivity of a Quorum-Sensing Signaling Molecule by Tsuchikama, Kyoji, Gooyit, Major, Harris, Tyler L., Zhu, Jie, Globisch, Daniel, Kaufmann, Gunnar F., Janda, Kim D.

“…Reported herein is that (4S)‐4,5‐dihydroxy‐2,3‐pentanedione (DPD) can undergo a previously undocumented non‐enzymatic glycation reaction. Incubation of DPD…”
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Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus by Harris, Tyler L., Worthington, Roberta J., Melander, Christian

“…Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi‐drug‐resistant bacteria, such as MRSA, to clinically available…”
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Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance by Harris, Tyler L, Worthington, Roberta J, Hittle, Lauren E, Zurawski, Daniel V, Ernst, Robert K, Melander, Christian

“…Infections caused by multi-drug resistant bacteria, particularly Gram-negative bacteria, are an ever-increasing problem. While the development of new…”
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Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria by Barker, William T., Martin, Sara E., Chandler, Courtney E., Nguyen, T.Vu, Harris, Tyler L., Goodell, Christopher, Melander, Roberta J., Doi, Yohei, Ernst, Robert K., Melander, Christian

“…[Display omitted] Bacterial resistance to polymyxin antibiotics has taken on a new and more menacing form. Common are genomically-encoded resistance mechanisms…”
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Gold nanoparticles to improve HIV drug delivery by Garrido, Carolina, Simpson, Carrie A, Dahl, Noelle P, Bresee, Jamee, Whitehead, Daniel C, Lindsey, Erick A, Harris, Tyler L, Smith, Candice A, Carter, Carly J, Feldheim, Daniel L, Melander, Christian, Margolis, David M

“…Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations,…”
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Disarming Pseudomonas aeruginosa Virulence Factor LasB by Leveraging a Caenorhabditis elegans Infection Model by Zhu, Jie, Cai, Xiaoqing, Harris, Tyler L., Gooyit, Major, Wood, Malcolm, Lardy, Matthew, Janda, Kim D.

“…The emergence of antibiotic resistance places a sense of urgency on the development of alternative antibacterial strategies, of which targeting virulence…”
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A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library by Harris, Tyler L., Worthington, Roberta J., Melander, Christian

“…An efficient synthetic route to 1,5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed. A library of simple…”
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Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping by Gooyit, Major, Harris, Tyler L, Tricoche, Nancy, Javor, Sacha, Lustigman, Sara, Janda, Kim D

“…The anthelmintic closantel has shown promise in abrogating the L3 molting of Onchocerca volvulus, the causative agent of the infectious disease onchocerciasis…”
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A Platform Stratifying a Sequestering Agent and a Pharmacological Antagonist as a Means to Negate Botulinum Neurotoxicity by Harris, Tyler L, Lowery, Colin A, Hixon, Mark S, Janda, Kim D

“…Botulinum neurotoxicity is characterized by peripheral neuromuscular blockade/flaccid paralysis that can lead to respiratory failure and ultimately death…”
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Glycation Reactivity of a Quorum-Sensing Signaling Molecule by Tsuchikama, Kyoji, Gooyit, Major, Harris, Tyler L., Zhu, Jie, Globisch, Daniel, Kaufmann, Gunnar F., Janda, Kim D.

“…Reported herein is that (4S)‐4,5‐dihydroxy‐2,3‐pentanedione (DPD) can undergo a previously undocumented non‐enzymatic glycation reaction. Incubation of DPD…”
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Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus by Harris, Tyler L, Worthington, Roberta J, Melander, Christian

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An Unprecedented Glycation Reactivity of a Quorum-Sensing Signaling Molecule by Tsuchikama, Kyoji, Gooyit, Major, Harris, Tyler L., Zhu, Jie, Globisch, Daniel, Kaufmann, Gunnar F., Janda, Kim D.

“…We report that the (4 S )-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with…”
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Potent Small Molecule Suppression of Oxacillin Resistance in MRSA by Harris, Tyler L., Worthington, Roberta J., Melander, Christian

“…The use of adjuvant molecules that have the ability to restore the susceptibility of multi-drug resistant bacteria, such as MRSA, to clinically available…”
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Bovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performance by Hergenreder, Jerilyn E., Baggerman, Jessica O., Harris, Tyler L., Thompson, Alex J., Spivey, Kari S., Broadway, P. Rand, Vogel, Gary J., Smith, Zachary K., Johnson, Bradley J.

“…The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and…”
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Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus by Harris, Tyler L., Worthington, Roberta J., Melander, Christian

“…Eine vielversprechende Alternative zur Entwicklung neuartiger Antimikrobika sind Hilfsmoleküle, die die Empfindlichkeit von multiresistenten Bakterien wie MRSA…”
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