Search Results - "Harris, Timothy D"
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Fully integrated silicon probes for high-density recording of neural activity
Published in Nature (London) (09-11-2017)“…New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents. High-density neural…”
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Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals
Published in Journal of neurophysiology (01-03-2014)“…Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we…”
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Evaluating the potential of using quantum dots for monitoring electrical signals in neurons
Published in Nature nanotechnology (01-04-2018)“…Success in the projects aimed at providing an advanced understanding of the brain is directly predicated on making critical advances in nanotechnology. This…”
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Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
Published in Neuron (Cambridge, Mass.) (25-09-2019)“…The classic approach to measure the spiking response of neurons involves the use of metal electrodes to record extracellular potentials. Starting over 60 years…”
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Excitation Spectra and Brightness Optimization of Two-Photon Excited Probes
Published in Biophysical journal (22-02-2012)“…Two-photon probe excitation data are commonly presented as absorption cross section or molecular brightness (the detected fluorescence rate per molecule). We…”
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Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance
Published in eLife (10-07-2024)“…Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in…”
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7
Single-Molecule DNA Sequencing of a Viral Genome
Published in Science (American Association for the Advancement of Science) (04-04-2008)“…The full promise of human genomics will be realized only when the genomes of thousands of individuals can be sequenced for comparative analysis. A reference…”
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Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes
Published in Nature communications (02-09-2021)“…State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically…”
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Robotic multi-probe single-actuator inchworm neural microdrive
Published in eLife (10-11-2022)“…A wide range of techniques in neuroscience involve placing individual probes at precise locations in the brain. However, large-scale measurement and…”
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10
Volitional activation of remote place representations with a hippocampal brain–machine interface
Published in Science (American Association for the Advancement of Science) (03-11-2023)“…The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations…”
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Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography
Published in Frontiers in neural circuits (12-11-2013)“…The subcellular locations of synapses on pyramidal neurons strongly influences dendritic integration and synaptic plasticity. Despite this, there is little…”
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Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
Published in Science (American Association for the Advancement of Science) (16-04-2021)“…Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months…”
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Neuropixels Data-Acquisition System: A Scalable Platform for Parallel Recording of 10 000+ Electrophysiological Signals
Published in IEEE transactions on biomedical circuits and systems (01-12-2019)“…Although CMOS fabrication has enabled a quick evolution in the design of high-density neural probes and neural-recording chips, the scaling and miniaturization…”
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Multimodal in vivo brain electrophysiology with integrated glass microelectrodes
Published in Nature biomedical engineering (01-09-2019)“…Electrophysiology is the most used approach for the collection of functional data in basic and translational neuroscience, but it is typically limited to…”
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Optical spectroscopy of a GaAs/AlGaAs quantum wire structure using near-field scanning optical microscopy
Published in Applied physics letters (14-03-1994)“…We report the first spectroscopic study using a low temperature near-field scanning optical microscope. We have studied an array of GaAs/AlGaAs cleaved edge…”
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Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance
Published in eLife (10-07-2024)“…Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in…”
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Raman studies of steric hindrance and surface relaxation of stepped H-terminated silicon surfaces
Published in Physical review letters (04-10-1993)Get full text
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First Organoid Intelligence (OI) workshop to form an OI community
Published in Frontiers in artificial intelligence (28-02-2023)“…The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals…”
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Two Photon Photophysics of Fluorescent Protein Calcium Indicators
Published in Biophysical journal (29-01-2013)Get full text
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Analytical Chemistry and Semiconductor Materials
Published in Analytical chemistry (Washington) (15-07-1990)“…Advances in analytical chemistry are crucial to the continued expansion of electronic and optoelectronic materials in device applications. This report explains…”
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