Search Results - "Harris, Thurl E."

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway by Peterson, Timothy R., Sengupta, Shomit S., Harris, Thurl E., Carmack, Anne E., Kang, Seong A., Balderas, Eric, Guertin, David A., Madden, Katherine L., Carpenter, Anne E., Finck, Brian N., Sabatini, David M.

“…The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy,…”
Get full text

Dual function lipin proteins and glycerolipid metabolism by Harris, Thurl E, Finck, Brian N

“…Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride synthesis, lipins act as lipid phosphatase enzymes at the…”
Get full text

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase by Pagac, Martin, Cooper, Daniel E., Qi, Yanfei, Lukmantara, Ivan E., Mak, Hoi Yin, Wu, Zengying, Tian, Yuan, Liu, Zhonghua, Lei, Mona, Du, Ximing, Ferguson, Charles, Kotevski, Damian, Sadowski, Pawel, Chen, Weiqin, Boroda, Salome, Harris, Thurl E., Liu, George, Parton, Robert G., Huang, Xun, Coleman, Rosalind A., Yang, Hongyuan

“…Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid…”
Get full text

Mechanism of sphingosine 1-phosphate clearance from blood by Kharel, Yugesh, Huang, Tao, Salamon, Anita, Harris, Thurl E, Santos, Webster L, Lynch, Kevin R

“…The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a…”
Get more information

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function by Martínez, Brittany A, Hoyle, Rosalie G, Yeudall, Scott, Granade, Mitchell E, Harris, Thurl E, Castle, J David, Leitinger, Norbert, Bland, Michelle L

“…During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize…”
Get full text

PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding by Wang, Lifu, Harris, Thurl E., Roth, Richard A., Lawrence, John C.

“…Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes, mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting…”
Get full text

Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight by Gaykema, Ronald P, Newmyer, Brandon A, Ottolini, Matteo, Raje, Vidisha, Warthen, Daniel M, Lambeth, Philip S, Niccum, Maria, Yao, Ting, Huang, Yiru, Schulman, Ira G, Harris, Thurl E, Patel, Manoj K, Williams, Kevin W, Scott, Michael M

“…Peptides derived from pre-proglucagon (GCG peptides) act in both the periphery and the CNS to change food intake, glucose homeostasis, and metabolic rate while…”
Get full text

Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression by Culver, Silas A., Hargett, Stefan R., Balugo, Jamie L. L. Q., Gildea, John J., Harris, Thurl E., Siragy, Helmy M.

“…ATP6AP2 knockout in the renal nephron impairs receptor-mediated endocytosis, increasing urinary albumin and glucose excretion and impairing weight gain…”
Get full text

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism by KUMAR, Anil, LAWRENCE, John C, DAE YOUNG JUNG, HWI JIN KO, KELLER, Susanna R, KIM, Jason K, MAGNUSON, Mark A, HARRIS, Thurl E

“…Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin…”
Get full text

Phosphorylation of Lipin 1 and Charge on the Phosphatidic Acid Head Group Control Its Phosphatidic Acid Phosphatase Activity and Membrane Association by Eaton, James M., Mullins, Garrett R., Brindley, David N., Harris, Thurl E.

“…The lipin gene family encodes a class of Mg2+-dependent phosphatidic acid phosphatases involved in the de novo synthesis of phospholipids and triglycerides…”
Get full text

Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering by Ware, Timothy B., Franks, Caroline E., Granade, Mitchell E., Zhang, Mingxing, Kim, Kee-Beom, Park, Kwon-Sik, Gahlmann, Andreas, Harris, Thurl E., Hsu, Ku-Lung

“…C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger…”
Get full text

Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation by Adamson, Samantha E, Griffiths, Rachael, Moravec, Radim, Senthivinayagam, Subramanian, Montgomery, Garren, Chen, Wenshu, Han, Jenny, Sharma, Poonam R, Mullins, Garrett R, Gorski, Stacey A, Cooper, Jonathan A, Kadl, Alexandra, Enfield, Kyle, Braciale, Thomas J, Harris, Thurl E, Leitinger, Norbert

“…Acute and chronic tissue injury results in the generation of a myriad of environmental cues that macrophages respond to by changing their phenotype and…”
Get full text

Lipin‐1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple‐negative breast cancer cell survival by He, Jingquan, Zhang, Feng, Rachel Tay, Li Wei, Boroda, Salome, Nian, Weiqi, Levental, Kandice R., Levental, Ilya, Harris, Thurl E., Chang, Jeffrey T., Du, Guangwei

“…ABSTRACT Cancer cells reprogram their metabolism to increase the synthesis of macromolecules for rapid proliferation. Compared to fatty acids, much less is…”
Get full text

Chemoproteomic capture of RNA binding activity in living cells by Heindel, Andrew J., Brulet, Jeffrey W., Wang, Xiantao, Founds, Michael W., Libby, Adam H., Bai, Dina L., Lemke, Michael C., Leace, David M., Harris, Thurl E., Hafner, Markus, Hsu, Ku-Lung

“…Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding…”
Get full text

Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation by Wang, Lifu, Harris, Thurl E., Lawrence, John C.

“…The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contains mTOR, raptor, mLST8, and PRAS40 (proline-rich Akt substrate of 40…”
Get full text

Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity by Derecka, Marta, Gornicka, Agnieszka, Koralov, Sergei B., Szczepanek, Karol, Morgan, Magdalena, Raje, Vidisha, Sisler, Jennifer, Zhang, Qifang, Otero, Dennis, Cichy, Joanna, Rajewsky, Klaus, Shimoda, Kazuya, Poli, Valeria, Strobl, Birgit, Pellegrini, Sandra, Harris, Thurl E., Seale, Patrick, Russell, Aaron P., McAinch, Andrew J., O’Brien, Paul E., Keller, Susanna R., Croniger, Colleen M., Kordula, Tomasz, Larner, Andrew C.

“…Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in…”
Get full text

Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha by Olmez, Inan, Love, Shawn, Xiao, Aizhen, Manigat, Laryssa, Randolph, Peyton, McKenna, Brian D, Neal, Brian P, Boroda, Salome, Li, Ming, Brenneman, Breanna, Abounader, Roger, Floyd, Desiree, Lee, Jeongwu, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Sulman, Erik P, Mayo, Marty, Gioeli, Daniel, Weber, Michael, Harris, Thurl E, Purow, Benjamin

“…The mesenchymal phenotype in glioblastoma (GBM) and other cancers drives aggressiveness and treatment resistance, leading to therapeutic failure and recurrence…”
Get full text

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling by Zhang, Chongben, Wendel, Angela A, Keogh, Matthew R, Harris, Thurl E, Chen, Jie, Coleman, Rosalind A

“…Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains…”
Get full text

Insulin-stimulated Interaction with 14-3-3 Promotes Cytoplasmic Localization of Lipin-1 in Adipocytes by Péterfy, Miklós, Harris, Thurl E., Fujita, Naoya, Reue, Karen

“…Lipin-1 is a bifunctional protein involved in lipid metabolism and adipogenesis. Lipin-1 plays a role in the biosynthesis of triacylglycerol through its…”
Get full text

Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity by Kumar, Anil, Harris, Thurl E., Keller, Susanna R., Choi, Kin M., Magnuson, Mark A., Lawrence, John C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text