Search Results - "Harris, Reuben S"

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity by Swanton, Charles, McGranahan, Nicholas, Starrett, Gabriel J, Harris, Reuben S

“…Deep sequencing technologies are revealing the complexities of cancer evolution, casting light on mutational processes fueling tumor adaptation, immune escape,…”
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Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer by Harris, Reuben S

“…Cancer genomic DNA sequences enable identification of all mutations and suggest targets for precision medicine. The identities and patterns of the mutations…”
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The Restriction Factors of Human Immunodeficiency Virus by Harris, Reuben S., Hultquist, Judd F., Evans, David T.

“…Cellular proteins called “restriction factors” can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent…”
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The APOBEC3 family of retroelement restriction factors by Refsland, Eric W, Harris, Reuben S

“…The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy…”
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Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses by Verhalen, Brandy, Starrett, Gabriel J, Harris, Reuben S, Jiang, Mengxi

“…The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and…”
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APOBEC3B is an enzymatic source of mutation in breast cancer by Burns, Michael B., Lackey, Lela, Carpenter, Michael A., Rathore, Anurag, Land, Allison M., Leonard, Brandon, Refsland, Eric W., Kotandeniya, Delshanee, Tretyakova, Natalia, Nikas, Jason B., Yee, Douglas, Temiz, Nuri A., Donohue, Duncan E., McDougle, Rebecca M., Brown, William L., Law, Emily K., Harris, Reuben S.

“…The DNA cytosine deaminase APOBEC3B is shown to be overexpressed and highly active in most breast cancers; deamination by APOBEC3B could serve as an…”
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APOBEC3A catalyzes mutation and drives carcinogenesis in vivo by Law, Emily K, Levin-Klein, Rena, Jarvis, Matthew C, Kim, Hyoung, Argyris, Prokopios P, Carpenter, Michael A, Starrett, Gabriel J, Temiz, Nuri A, Larson, Lindsay K, Durfee, Cameron, Burns, Michael B, Vogel, Rachel I, Stavrou, Spyridon, Aguilera, Alexya N, Wagner, Sandra, Largaespada, David A, Starr, Timothy K, Ross, Susan R, Harris, Reuben S

“…The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a…”
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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B by Shi, Ke, Carpenter, Michael A, Banerjee, Surajit, Shaban, Nadine M, Kurahashi, Kayo, Salamango, Daniel J, McCann, Jennifer L, Starrett, Gabriel J, Duffy, Justin V, Demir, Özlem, Amaro, Rommie E, Harki, Daniel A, Harris, Reuben S, Aihara, Hideki

“…Crystal structures of human APOBEC3A and a chimera of APOBEC3B and APOBEC3A bound to ssDNA reveal an unanticipated ‘U-shaped’ binding mode and provide insight…”
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Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain by Shi, Ke, Carpenter, Michael A., Kurahashi, Kayo, Harris, Reuben S., Aihara, Hideki

“…Functional and deep sequencing studies have combined to demonstrate the involvement of APOBEC3B in cancer mutagenesis. APOBEC3B is a single-stranded DNA…”
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APOBEC3 proteins mediate the clearance of foreign DNA from human cells by Harris, Reuben S, Stenglein, Mark D, Burns, Michael B, Li, Ming, Lengyel, Joy

“…APOBEC3 cytidine deaminases have been implicated in restriction of retroviruses and retrotransposons in mammalian cells. Now human APOBEC3A is shown to be…”
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Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1 by HULTQUIST, Judd F, LENGYEL, Joy A, REFSLAND, Eric W, LARUE, Rebecca S, LACKEY, Lela, BROWN, William L, HARRIS, Reuben S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest by Salamango, Daniel J, Harris, Reuben S

“…Accessory proteins are a key feature that distinguishes primate immunodeficiency viruses such as human immunodeficiency virus type I (HIV-1) from other…”
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The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis by Starrett, Gabriel J., Luengas, Elizabeth M., McCann, Jennifer L., Ebrahimi, Diako, Temiz, Nuri A., Love, Robin P., Feng, Yuqing, Adolph, Madison B., Chelico, Linda, Law, Emily K., Carpenter, Michael A., Harris, Reuben S

“…Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B -null breast tumours…”
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Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction by Refsland, Eric W, Stenglein, Mark D, Shindo, Keisuke, Albin, John S, Brown, William L, Harris, Reuben S

“…The human APOBEC3 proteins are DNA cytidine deaminases that impede the replication of many different transposons and viruses. The genes that encode APOBEC3A,…”
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Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes by Harris, Reuben S, Anderson, Brett D

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APOBEC3B and APOBEC3F Inhibit L1 Retrotransposition by a DNA Deamination-independent Mechanism by Stenglein, Mark D., Harris, Reuben S.

“…The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related…”
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Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template by Aird, Eric J., Lovendahl, Klaus N., St. Martin, Amber, Harris, Reuben S., Gordon, Wendy R.

“…The CRISPR-Cas9 system is a powerful genome-editing tool in which a guide RNA targets Cas9 to a site in the genome, where the Cas9 nuclease then induces a…”
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Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination by Lackey, Lela, Law, Emily K., Brown, William L., Harris, Reuben S.

“…Humans have seven APOBEC3 DNA cytosine deaminases. The activity of these enzymes allows them to restrict a variety of retroviruses and retrotransposons, but…”
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A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain by Esler, Morgan A, Belica, Christopher A, Rollie, Joseph A, Brown, William L, Moghadasi, Seyed Arad, Shi, Ke, Harki, Daniel A, Harris, Reuben S, Aihara, Hideki

“…SARS-CoV-2 nucleocapsid (N) protein is a structural component of the virus with essential roles in the replication and packaging of the viral RNA genome. The N…”
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Extensive somatic L1 retrotransposition in colorectal tumors by Solyom, Szilvia, Ewing, Adam D, Rahrmann, Eric P, Doucet, Tara, Nelson, Heather H, Burns, Michael B, Harris, Reuben S, Sigmon, David F, Casella, Alex, Erlanger, Bracha, Wheelan, Sarah, Upton, Kyle R, Shukla, Ruchi, Faulkner, Geoffrey J, Largaespada, David A, Kazazian, Jr, Haig H

“…L1 retrotransposons comprise 17% of the human genome and are its only autonomous mobile elements. Although L1-induced insertional mutagenesis causes Mendelian…”
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