Search Results - "Harris, Peter C."

Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases by Cornec-Le Gall, Emilie, Torres, Vicente E, Harris, Peter C

“…Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between two groups of inherited disorders, autosomal dominant…”
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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease by Harris, Peter C, Torres, Vicente E

“…Recent advances in defining the genetic mechanisms of disease causation and modification in autosomal dominant polycystic kidney disease (ADPKD) have helped to…”
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Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease by TORRES, Vicente E, HARRIS, Peter C

“…Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of…”
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Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease by Ding, Hao, Li, Linda Xiaoyan, Harris, Peter C., Yang, Junwei, Li, Xiaogang

“…Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the…”
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Autosomal dominant polycystic kidney disease: the last 3 years by Torres, Vicente E., Harris, Peter C.

“…Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal monogenic disorder. It has large inter- and intra-familial variability…”
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Polycystic kidney disease by Harris, Peter C, Torres, Vicente E

“…A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder…”
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A polycystin-centric view of cyst formation and disease: the polycystins revisited by Ong, Albert C M, Harris, Peter C

“…It is 20 years since the identification of PKD1, the major gene mutated in autosomal dominant polycystic kidney disease (ADPKD), followed closely by the…”
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Autosomal dominant polycystic kidney disease by Torres, Vicente E, MD, Harris, Peter C, PhD, Pirson, Yves, MD

“…Summary Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial…”
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Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing by Lanktree, Matthew B, Haghighi, Amirreza, Guiard, Elsa, Iliuta, Ioan-Andrei, Song, Xuewen, Harris, Peter C, Paterson, Andrew D, Pei, York

“…Estimating the prevalence of autosomal dominant polycystic kidney disease (ADPKD) is challenging because of age-dependent penetrance and incomplete clinical…”
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Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease by Porath, Binu, Gainullin, Vladimir G., Cornec-Le Gall, Emilie, Dillinger, Elizabeth K., Heyer, Christina M., Hopp, Katharina, Edwards, Marie E., Madsen, Charles D., Mauritz, Sarah R., Banks, Carly J., Baheti, Saurabh, Reddy, Bharathi, Herrero, José Ignacio, Bañales, Jesús M., Hogan, Marie C., Tasic, Velibor, Watnick, Terry J., Chapman, Arlene B., Vigneau, Cécile, Lavainne, Frédéric, Audrézet, Marie-Pierre, Ferec, Claude, Le Meur, Yannick, Torres, Vicente E., Harris, Peter C.

“…Autosomal-dominant polycystic kidney disease (ADPKD) is a common, progressive, adult-onset disease that is an important cause of end-stage renal disease…”
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Food Restriction Ameliorates the Development of Polycystic Kidney Disease by Warner, Gina, Hein, Kyaw Zaw, Nin, Veronica, Edwards, Marika, Chini, Claudia C S, Hopp, Katharina, Harris, Peter C, Torres, Vicente E, Chini, Eduardo N

“…Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the accumulation of kidney cysts that ultimately leads to loss of…”
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Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease by Schrier, Robert W, Abebe, Kaleab Z, Perrone, Ronald D, Torres, Vicente E, Braun, William E, Steinman, Theodore I, Winklhofer, Franz T, Brosnahan, Godela, Czarnecki, Peter G, Hogan, Marie C, Miskulin, Dana C, Rahbari-Oskoui, Frederic F, Grantham, Jared J, Harris, Peter C, Flessner, Michael F, Bae, Kyongtae T, Moore, Charity G, Chapman, Arlene B

“…In patients with autosomal dominant polycystic kidney disease, the rate of increase in total kidney volume was not slowed by lisinopril and telmisartan, as…”
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Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity by Hopp, Katharina, Ward, Christopher J, Hommerding, Cynthia J, Nasr, Samih H, Tuan, Han-Fang, Gainullin, Vladimir G, Rossetti, Sandro, Torres, Vicente E, Harris, Peter C

“…Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or PKD2, triggering progressive cystogenesis and typically leading to…”
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Refining Genotype-Phenotype Correlation in Autosomal Dominant Polycystic Kidney Disease by Hwang, Young-Hwan, Conklin, John, Chan, Winnie, Roslin, Nicole M, Liu, Jannel, He, Ning, Wang, Kairong, Sundsbak, Jamie L, Heyer, Christina M, Haider, Masoom, Paterson, Andrew D, Harris, Peter C, Pei, York

“…Renal disease variability in autosomal dominant polycystic kidney disease (ADPKD) is strongly influenced by the gene locus (PKD1 versus PKD2). Recent studies…”
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Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD) by Perrone, Ronald D, Abebe, Kaleab Z, Watnick, Terry J, Althouse, Andrew D, Hallows, Kenneth R, Lalama, Christina M, Miskulin, Dana C, Seliger, Stephen L, Tao, Cheng, Harris, Peter C, Bae, Kyongtae Ty

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by growth of kidney cysts and glomerular filtration rate (GFR) decline. Metformin was…”
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microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism by Hajarnis, Sachin, Lakhia, Ronak, Yheskel, Matanel, Williams, Darren, Sorourian, Mehran, Liu, Xueqing, Aboudehen, Karam, Zhang, Shanrong, Kersjes, Kara, Galasso, Ryan, Li, Jian, Kaimal, Vivek, Lockton, Steven, Davis, Scott, Flaten, Andrea, Johnson, Joshua A., Holland, William L., Kusminski, Christine M., Scherer, Philipp E., Harris, Peter C., Trudel, Marie, Wallace, Darren P., Igarashi, Peter, Lee, Edmund C., Androsavich, John R., Patel, Vishal

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment…”
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Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease by Rossetti, Sandro, Harris, Peter C

“…The phenotypes that are associated with the common forms of polycystic kidney disease (PKD)--autosomal dominant (ADPKD) and autosomal recessive (ARPKD)--are…”
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Imaging-based diagnosis of autosomal dominant polycystic kidney disease by Pei, York, Hwang, Young-Hwan, Conklin, John, Sundsbak, Jamie L, Heyer, Christina M, Chan, Winnie, Wang, Kairong, He, Ning, Rattansingh, Anand, Atri, Mostafa, Harris, Peter C, Haider, Masoom A

“…The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic kidney disease (ADPKD) is currently limited by reduced diagnostic…”
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Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease by Torres, Vicente E, Abebe, Kaleab Z, Chapman, Arlene B, Schrier, Robert W, Braun, William E, Steinman, Theodore I, Winklhofer, Franz T, Brosnahan, Godela, Czarnecki, Peter G, Hogan, Marie C, Miskulin, Dana C, Rahbari-Oskoui, Frederic F, Grantham, Jared J, Harris, Peter C, Flessner, Michael F, Moore, Charity G, Perrone, Ronald D

“…This trial tested single versus dual inhibition of the renin–angiotensin–aldosterone system in ADPKD. ACE-inhibitor monotherapy controlled blood pressure in…”
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Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease by Nowak, Kristen L, You, Zhiying, Gitomer, Berenice, Brosnahan, Godela, Torres, Vicente E, Chapman, Arlene B, Perrone, Ronald D, Steinman, Theodore I, Abebe, Kaleab Z, Rahbari-Oskoui, Frederic F, Yu, Alan S L, Harris, Peter C, Bae, Kyongtae T, Hogan, Marie, Miskulin, Dana, Chonchol, Michel

“…The association of overweight/obesity with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested. We…”
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