Search Results - "Harris, Michael R."

Synthesis of Enantioenriched Triarylmethanes by Stereospecific Cross-Coupling Reactions by Taylor, Buck L. H., Harris, Michael R., Jarvo, Elizabeth R.

“…Coupling with inversion: Chiral diarylmethanol derivatives undergo a stereospecific nickel‐catalyzed cross‐coupling reaction with aryl Grignard reagents (see…”
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A Modular Approach to the Synthesis of gem-Disubstituted Cyclopropanes by Harris, Michael R, Wisniewska, Hanna M, Jiao, Wenhua, Wang, Xiaochun, Bradow, James N

“…A diastereoselective, Pd-catalyzed Suzuki–Miyaura coupling reaction of geminal bis­(boryl)­cyclopropanes has been developed. The reaction offers a highly…”
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DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication by Mattiroli, Francesca, Gu, Yajie, Yadav, Tejas, Balsbaugh, Jeremy L, Harris, Michael R, Findlay, Eileen S, Liu, Yang, Radebaugh, Catherine A, Stargell, Laurie A, Ahn, Natalie G, Whitehouse, Iestyn, Luger, Karolin

“…Nucleosome assembly in the wake of DNA replication is a key process that regulates cell identity and survival. Chromatin assembly factor 1 (CAF-1) is a H3-H4…”
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Computational Inference of Synaptic Polarities in Neuronal Networks by Harris, Michael R., Wytock, Thomas P., Kovács, István A.

“…Synaptic polarity, that is, whether synapses are inhibitory (−) or excitatory (+), is challenging to map, despite being a key to understand brain function…”
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Binding specificity of the G1/S transcriptional regulators in budding yeast by Harris, Michael R, Lee, Dave, Farmer, Sarah, Lowndes, Noel F, de Bruin, Robertus A M

“…G1/S transcriptional regulation in the budding yeast Saccharomyces cerevisiae depends on three main transcriptional components, Swi4, Swi6 and Mbp1. These…”
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Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms by Wood, Thomas J, Thistlethwaite, Angela, Harris, Michael R, Lovell, Simon C, Millar, Catherine B

“…The incorporation of histone variants into nucleosomes is a critical mechanism for regulating essential DNA-templated processes and for establishing distinct…”
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Derivation and Characterization of an Extra-Axial Chordoma Cell Line (EACH-1) from a Scapular Tumor by DeComas, Amalia M., Penfornis, Patrice, Harris, Michael R., Meyer, Mark S., Pochampally, Radhika R.

“…Extra-axial chordomas are rare low-grade malignant tumors thought to arise from notochordal remnants in the extra-axial skeleton. Few studies have been done on…”
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Enantiospecific Intramolecular Heck Reactions of Secondary Benzylic Ethers by Harris, Michael R, Konev, Mikhail O, Jarvo, Elizabeth R

“…Enantioenriched methylene­cyclo­pentanes are synthesized by stereospecific, nickel-catalyzed Heck cyclizations of secondary benzylic ethers. The reaction…”
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The checkpoint transcriptional response: Make sure to turn it off once you are satisfied by Smolka, Marcus B., Bastos de Oliveira, Francisco M., Harris, Michael R., de Bruin, Robertus A.M.

“…The replication checkpoint signaling network monitors the presence of replication-induced lesions to DNA and coordinates an elaborate cellular response that…”
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Retention or Inversion in Stereospecific Nickel-Catalyzed Cross-Coupling of Benzylic Carbamates with Arylboronic Esters: Control of Absolute Stereochemistry with an Achiral Catalyst by Harris, Michael R, Hanna, Luke E, Greene, Margaret A, Moore, Curtis E, Jarvo, Elizabeth R

“…Stereospecific coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters has been developed. The reaction proceeds with selective…”
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Virus Subversion of the MHC Class I Peptide-Loading Complex by Lybarger, Lonnie, Wang, Xiaoli, Harris, Michael R, Virgin, Herbert W, Hansen, Ted H

“…Many viral proteins modulate class I expression, yet, in general, their mechanisms of specific class I recognition are poorly understood. The mK3 protein of γ…”
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Mechanism and Origins of Ligand-Controlled Stereoselectivity of Ni‑Catalyzed Suzuki–Miyaura Coupling with Benzylic Esters: A Computational Study by Zhang, Shuo-Qing, Taylor, Buck L. H, Ji, Chong-Lei, Gao, Yuan, Harris, Michael R, Hanna, Luke E, Jarvo, Elizabeth R, Houk, K. N, Hong, Xin

“…Nickel catalysts have shown unique ligand control of stereoselectivity in the Suzuki–Miyaura cross-coupling of boronates with benzylic pivalates and…”
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The Combined Effect of Encapsulating Curcumin and C6 Ceramide in Liposomal Nanoparticles against Osteosarcoma by Dhule, Santosh S, Penfornis, Patrice, He, Jibao, Harris, Michael R, Terry, Treniece, John, Vijay, Pochampally, Radhika

“…This study examines the antitumor potential of curcumin and C6 ceramide (C6) against osteosarcoma (OS) cell lines when both are encapsulated in the bilayer of…”
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Model for the Interaction of Gammaherpesvirus 68 RING-CH Finger Protein mK3 with Major Histocompatibility Complex Class I and the Peptide-Loading Complex by XIAOLI WANE, LYBARGER, Lonnie, CONNORS, Rose, HARRIS, Michael R, HANSEN, Ted H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nickel-Catalyzed Hydrogenolysis and Conjugate Addition of 2‑(Hydroxymethyl)pyridines via Organozinc Intermediates by Hanna, Luke E, Harris, Michael R, Domon, Kenji, Jarvo, Elizabeth R

“…2-Hydroxymethylpyridines undergo nickel-catalyzed hydrogenolysis upon activation with a chlorophosphate. Reactions employ diethylzinc and are proposed to…”
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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4 by Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, Varghese, Alison E.

“…A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging…”
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Requirements for the Selective Degradation of Endoplasmic Reticulum-Resident Major Histocompatibility Complex Class I Proteins by the Viral Immune Evasion Molecule mK3 by XIAOLI WANG, CONNORS, Rose, HARRIS, Michael R, HANSEN, Ted H, LYBARGER, Lonnie

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Construction of 1-Heteroaryl-3-azabicyclo[3.1.0]hexanes by sp 3 -sp 2 Suzuki-Miyaura and Chan-Evans-Lam Coupling Reactions of Tertiary Trifluoroborates by Harris, Michael R, Li, Qifang, Lian, Yajing, Xiao, Jun, Londregan, Allyn T

“…Compounds that contain the 1-heteroaryl-3-azabicyclo[3.1.0]hexane architecture are of particular interest to the pharmaceutical industry yet remain a challenge…”
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Selective synthesis of either enantiomer of an anti-breast cancer agent via a common enantioenriched intermediate by Johnson, Aaron George, Tranquilli, Marissa M., Harris, Michael R., Jarvo, Elizabeth R.

“…[Display omitted] A stereoselective synthesis of a bioactive triarylmethane is described. Key to the synthesis is a nickel-catalyzed Suzuki–Miyaura coupling…”
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Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes by Bastos de Oliveira, Francisco M, Harris, Michael R, Brazauskas, Pijus, de Bruin, Robertus A M, Smolka, Marcus B

“…Reprogramming gene expression is crucial for DNA replication stress response. We used quantitative proteomics to establish how the transcriptional response…”
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