Search Results - "Harris, Marian H."

MicroRNA miR-125b causes leukemia by Bousquet, Marina, Harris, Marian H., Zhou, Beiyan, Lodish, Harvey F.

“…MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and…”
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Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy by Church, Alanna J, Calicchio, Monica L, Nardi, Valentina, Skalova, Alena, Pinto, Andre, Dillon, Deborah A, Gomez-Fernandez, Carmen R, Manoj, Namitha, Haimes, Josh D, Stahl, Joshua A, Dela Cruz, Filemon S, Tannenbaum-Dvir, Sarah, Glade-Bender, Julia L, Kung, Andrew L, DuBois, Steven G, Kozakewich, Harry P, Janeway, Katherine A, Perez-Atayde, Antonio R, Harris, Marian H

“…Infantile fibrosarcoma and congenital mesoblastic nephroma are tumors of infancy traditionally associated with the ETV6–NTRK3 gene fusion. However, a number of…”
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Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 by Camargo, Fernando D, Johnnidis, Jonathan B, Harris, Marian H, Wheeler, Robert T, Stehling-Sun, Sandra, Lam, Michael H, Kirak, Oktay, Brummelkamp, Thijn R, Fleming, Mark D

“…MicroRNAs are abundant in animal genomes and have been predicted to have important roles in a broad range of gene expression programmes. Despite this…”
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Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l -asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial by Place, Andrew E, MD, Stevenson, Kristen E, MS, Vrooman, Lynda M, MD, Harris, Marian H, MD, Hunt, Sarah K, MPH, O'Brien, Jane E, BA, Supko, Jeffrey G, PhD, Asselin, Barbara L, MD, Athale, Uma H, MD, Clavell, Luis A, Prof, Cole, Peter D, MD, Kelly, Kara M, Prof, Laverdiere, Caroline, MD, Leclerc, Jean-Marie, MD, Michon, Bruno, MD, Schorin, Marshall A, Prof, Welch, Jennifer J G, MD, Lipshultz, Steven E, Prof, Kutok, Jeffery L, MD, Blonquist, Traci M, MS, Neuberg, Donna S, ScD, Sallan, Stephen E, Prof, Silverman, Lewis B, Dr

“…Summary Background l -asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered…”
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Recurrent and novel USP6 fusions in cranial fasciitis identified by targeted RNA sequencing by Paulson, Vera A., Stojanov, Ivan A., Wasman, Jay K., Restrepo, Tamara, Cano, Samantha, Plunkitt, Joanna, Duraisamy, Sekhar, Harris, Marian H., Chute, Deborah J., Al-Ibraheemi, Alyaa, Church, Alanna J.

“…Cranial fasciitis is a benign myofibroproliferative lesion of the scalp and underlying bones typically occurring in the pediatric population. Histologically,…”
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Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors by Lizarraga, Sofia B, Margossian, Steven P, Harris, Marian H, Campagna, Dean R, Han, An-Ping, Blevins, Sherika, Mudbhary, Raksha, Barker, Jane E, Walsh, Christopher A, Fleming, Mark D

“…Microcephaly affects approximately 1% of the population and is associated with mental retardation, motor defects and, in some cases, seizures. We analyzed the…”
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Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers by Cheong, Taek-Chin, Jang, Ahram, Wang, Qi, Leonardi, Giulia C., Ricciuti, Biagio, Alessi, Joao V., Di Federico, Alessandro, Awad, Mark M., Lehtinen, Maria K., Harris, Marian H., Chiarle, Roberto

“…Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes…”
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Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis by Lum, Julian J., Bauer, Daniel E., Kong, Mei, Harris, Marian H., Li, Chi, Lindsten, Tullia, Thompson, Craig B.

“…In animals, cells are dependent on extracellular signals to prevent apoptosis. However, using growth factor-dependent cells from Bax/Bak-deficient mice, we…”
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ETV6 fusions from insertions of exons 3-5 in pediatric hematologic malignancies by Mueller, Sarah B, Pikman, Yana, Tasian, Sarah K, Silverman, Lewis B, Harris, Marian H, Tsai, Harrison K

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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation by Lane, Andrew A, Chapuy, Bjoern, Lin, Charles Y, Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C, van Bodegom, Diederik, Day, Tovah A, Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C, Sullivan, Timothy J, Malinge, Sébastien, Taylor, Jordan E, Stegmaier, Kimberly, Jaffe, Jacob D, Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian H, Stevenson, Kristen E, Neuberg, Donna, Silverman, Lewis B, Sallan, Stephen E, Bradner, James E, Hahn, William C, Crispino, John D, Pellman, David, Weinstock, David M

“…David Weinstock and colleagues identify a triplication at chromosome 21q22 that is associated with development of B cell acute lymphoblastic leukemia (B-ALL)…”
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Akt stimulates aerobic glycolysis in cancer cells by ELSTROM, Rebecca L, BAUER, Daniel E, THOMPSON, Craig B, BUZZAI, Monica, KARNAUSKAS, Robyn, HARRIS, Marian H, PLAS, David R, HONGMING ZHUANG, CINALLI, Ryan M, ALAVI, Abass, RUDIN, Charles M

“…Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this…”
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IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia by Paolino, Jonathan, Tsai, Harrison K, Harris, Marian H, Pikman, Yana

“…encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key role in lymphoid lineage development. IKAROS plays a critical role in the…”
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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia by Pouliot, Gayle P, Degar, James, Hinze, Laura, Kochupurakkal, Bose, Vo, Chau D, Burns, Melissa A, Moreau, Lisa, Ganesa, Chirag, Roderick, Justine, Peirs, Sofie, Menten, Bjorn, Loh, Mignon L, Hunger, Stephen P, Silverman, Lewis B, Harris, Marian H, Stevenson, Kristen E, Weinstock, David M, Weng, Andrew P, Van Vlierberghe, Pieter, D'Andrea, Alan D, Gutierrez, Alejandro

“…BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of…”
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Future of Clinical Genomics in Pediatric Oncology by Janeway, Katherine A, Place, Andrew E, Kieran, Mark W, Harris, Marian H

“…The somatic genomic alterations in pediatric cancers to some extent overlap with those seen in adult cancers, but the exact distribution throughout the genome…”
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Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001 by Vrooman, Lynda M., Blonquist, Traci M., Harris, Marian H., Stevenson, Kristen E., Place, Andrew E., Hunt, Sarah K., O'Brien, Jane E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Sulis, Maria Luisa, Welch, Jennifer J.G., Neuberg, Donna S., Sallan, Stephen E., Silverman, Lewis B.

“…Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 05-001 tested a new risk stratification system in children and adolescents with newly diagnosed…”
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The CD28 Signaling Pathway Regulates Glucose Metabolism by Frauwirth, Kenneth A, Riley, James L, Harris, Marian H, Parry, Richard V, Rathmell, Jeffrey C, Plas, David R, Elstrom, Rebecca L, June, Carl H, Thompson, Craig B

“…Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increases metabolic demand. Although T cells increase glucose…”
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Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors by Forester, Craig M., Sartain, Sarah E., Guo, Dongjing, Harris, Marian H., Weinberg, Olga K., Fleming, Mark D., London, Wendy B., Williams, David A., Hofmann, Inga

“…Pediatric acquired aplastic anemia (AA) is a bone marrow disorder that is difficult to distinguish from inherited bone marrow failure syndromes and…”
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Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia by Tran, Thai Hoa, Harris, Marian H., Nguyen, Jonathan V., Blonquist, Traci M., Stevenson, Kristen E., Stonerock, Eileen, Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Welch, Jennifer J.G., Reshmi, Shalini C., Neuberg, Donna S., Sallan, Stephen E., Loh, Mignon L., Silverman, Lewis B.

“…Recurrent chromosomal rearrangements carry prognostic significance in pediatric B-lineage acute lymphoblastic leukemia (B-ALL). Recent genome-wide analyses…”
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Gene Rearrangement Detection in Pediatric Leukemia by Harris, Marian H.

“…The detection of gene rearrangements in pediatric leukemia is an essential component of the work-up, with implications for accurate diagnosis, proper risk…”
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth by Cantley, Lewis C, Christofk, Heather R, Vander Heiden, Matthew G, Harris, Marian H, Ramanathan, Arvind, Gerszten, Robert E, Wei, Ru, Fleming, Mark D, Schreiber, Stuart L

“…Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high lactate production by tumours…”
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