Search Results - "Harris, Jonathan M"

Correlation of Experimental and Calculated Inhibition Constants of Protease Inhibitor Complexes by Goettig, Peter, Chen, Xingchen, Harris, Jonathan M

“…Predicting the potency of inhibitors is key to in silico screening of promising synthetic or natural compounds. Here we describe a predictive workflow that…”
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Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition by de Veer, Simon J, Swedberg, Joakim E, Akcan, Muharrem, Rosengren, K Johan, Brattsand, Maria, Craik, David J, Harris, Jonathan M

“…Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesizing a peptide bond. Studies…”
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Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold by Swedberg, Joakim E, Mahatmanto, Tunjung, Abdul Ghani, Hafiza, de Veer, Simon J, Schroeder, Christina I, Harris, Jonathan M, Craik, David J

“…Thrombosis is a leading cause of morbidity and mortality associated with cardiovascular diseases. Inhibition of factor XIIa (FXIIa) provides thrombus…”
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Plasmin Substrate Binding Site Cooperativity Guides the Design of Potent Peptide Aldehyde Inhibitors by Swedberg, Joakim E, Harris, Jonathan M

“…Perioperative bleeding is a cause of major blood loss and is associated with increased rates of postoperative morbidity and mortality. To combat this,…”
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Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype by Wallace, Daniel F, Harris, Jonathan M, Subramaniam, V Nathan

“…Ferroportin disease is a heterogeneous iron release disorder resulting from mutations in the ferroportin gene. Ferroportin protein is a multitransmembrane…”
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Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase by Leahy, Darren, Grant, Cameron, Jackson, Alex, Duff, Alex, Tardiota, Nicholas, Van Haeften, Jessica, Chen, Xingchen, Peake, Jonathan M., Kruppa, Michael D., Smith, Eliot T., Johnson, David A., Lott, William B., Harris, Jonathan M.

“…Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the…”
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Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment by Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E, Boyle, Glen M, Parsons, Peter G, McGuckin, Michael A, Harris, Jonathan M, Clements, Judith A

“…High tumor kallikrein-related-peptidase 4 (KLK4) levels are associated with a poor outcome for women with serous epithelial ovarian cancer (EOC), for which…”
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Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif by Chen, Xingchen, Riley, Blake T, de Veer, Simon J, Hoke, David E, Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E, Brattsand, Maria, Hartfield, Perry J, Buckle, Ashley M, Harris, Jonathan M

“…Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski…”
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A TriAdj-Adjuvanted Chlamydia trachomatis CPAF Protein Vaccine Is Highly Immunogenic in Pigs by Proctor, Jessica, Stadler, Maria, Cortes, Lizette M, Brodsky, David, Poisson, Lydia, Gerdts, Volker, Smirnov, Alex I, Smirnova, Tatyana I, Barua, Subarna, Leahy, Darren, Beagley, Kenneth W, Harris, Jonathan M, Darville, Toni, Käser, Tobias

“…( ) infections are the most common sexually transmitted infection (STI). Despite effective antibiotics for , undetected infections or delayed treatment can…”
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Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network by Swedberg, Joakim E, de Veer, Simon J, Sit, Kei C, Reboul, Cyril F, Buckle, Ashley M, Harris, Jonathan M

“…Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s)…”
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Natural and Engineered Plasmin Inhibitors: Applications and Design Strategies by Swedberg, Joakim E., Harris, Jonathan M.

“…The serine protease plasmin is ubiquitously expressed throughout the human body in the form of the zymogen plasminogen. Conversion to active plasmin occurs…”
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An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity by Moore, Nicole L, Buchanan, Grant, Harris, Jonathan M, Selth, Luke A, Bianco-Miotto, Tina, Hanson, Adrienne R, Birrell, Stephen N, Butler, Lisa M, Hickey, Theresa E, Tilley, Wayne D

“…Recent evidence indicates that the estrogen receptor-α-negative, androgen receptor (AR)-positive molecular apocrine subtype of breast cancer is driven by AR…”
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Mutation of the Androgen Receptor Causes Oncogenic Transformation of the Prostate by Han, Guangzhou, Buchanan, Grant, Ittmann, Michael, Harris, Jonathan M., Yu, Xiaoqing, DeMayo, Francesco J., Tilley, Wayne, Greenberg, Norman M., Allison, James P.

“…Recent evidence demonstrates that the androgen receptor (AR) continues to influence prostate cancer growth despite medical therapies that reduce circulating…”
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Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14 by de Veer, Simon J, Swedberg, Joakim E, Parker, Edward A, Harris, Jonathan M

“…An array of substrates link the tryptic serine protease, kallikrein-related peptidase 14 (KLK14), to physiological functions including desquamation and…”
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Increased Prefrontal Gyrification in a Large High-Risk Cohort Characterizes Those Who Develop Schizophrenia and Reflects Abnormal Prefrontal Development by Harris, Jonathan M, Moorhead, T. William J, Miller, Patrick, McIntosh, Andrew M, Bonnici, Heidi M, Owens, David G.C, Johnstone, Eve C, Lawrie, Stephen M

“…Background In our cohort considered at high risk (HR) of developing schizophrenia, we previously found a significant difference in extent of right prefrontal…”
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Proteases and proteomics: Cutting to the core of human skin pathologies by de Veer, Simon J., Furio, Laetitia, Harris, Jonathan M., Hovnanian, Alain

“…Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the…”
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Aprataxin Forms a Discrete Branch in the HIT (Histidine Triad) Superfamily of Proteins with Both DNA/RNA Binding and Nucleotide Hydrolase Activities by Kijas, Amanda W., Harris, Janelle L., Harris, Jonathan M., Lavin, Martin F.

“…Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset autosomal recessive spinocerebellar ataxia with a defect in the protein Aprataxin, implicated in…”
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The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine by Wansa, K D Senali Abayratna, Harris, Jonathan M, Yan, Grace, Ordentlich, Peter, Muscat, George E O

“…NOR-1/NR4A3 is an “orphan member” of the nuclear hormone receptor superfamily. NOR-1 and its close relatives Nurr1 and Nur77 are members of the NR4A…”
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Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia? by Harris, Jonathan M, Whalley, Heather, Yates, Shona, Miller, Patrick, Johnstone, Eve C, Lawrie, Stephen M

“…A number of studies have found localized differences in the appearance and extent of cortical folding between the brains of schizophrenic patients and healthy…”
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Pre-frontal lobe gyrification index in schizophrenia, mental retardation and comorbid groups: An automated study by Bonnici, Heidi M., William, T., Moorhead, J., Stanfield, Andrew C., Harris, Jonathan M., Owens, David G., Johnstone, Eve C., Lawrie, Stephen M.

“…In this paper, we describe the application of an automated method of calculating Gyrification Index (GI) – the Automated GI (A-GI) – to a total of 95…”
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