Search Results - "Harris, Isaac S."

The Complex Interplay between Antioxidants and ROS in Cancer by Harris, Isaac S., DeNicola, Gina M.

“…Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the…”
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Modulation of oxidative stress as an anticancer strategy by Gorrini, Chiara, Harris, Isaac S., Mak, Tak W.

“…Key Points The role of reactive oxygen species (ROS) in tumorigenesis is controversial, as they have been shown to have both tumour-promoting and…”
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Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

“…Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven…”
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Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells by Coloff, Jonathan L., Murphy, J. Patrick, Braun, Craig R., Harris, Isaac S., Shelton, Laura M., Kami, Kenjiro, Gygi, Steven P., Selfors, Laura M., Brugge, Joan S.

“…Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of…”
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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance by Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.

“…Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a…”
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Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome” by Karisch, Robert, Fernandez, Minerva, Taylor, Paul, Virtanen, Carl, St-Germain, Jonathan R., Jin, Lily L., Harris, Isaac S., Mori, Jun, Mak, Tak W., Senis, Yotis A., Östman, Arne, Moran, Michael F., Neel, Benjamin G.

“…Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active…”
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FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2 by Bakker, Walbert J., Harris, Isaac S., Mak, Tak W.

“…FOXO transcription factors are important regulators of cell survival in response to a variety of stress stimuli, among which are oxidative stress, DNA damage,…”
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function by Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

“…Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and…”
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics by Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari, Zúñiga-Pflücker, Juan-Carlos, Mak, Tak W.

“…Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation…”
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TAp73 depletion accelerates aging through metabolic dysregulation by Rufini, Alessandro, Niklison-Chirou, Maria Victoria, Inoue, Satoshi, Tomasini, Richard, Harris, Isaac S, Marino, Arianna, Federici, Massimo, Dinsdale, David, Knight, Richard A, Melino, Gerry, Mak, Tak Wah

“…Aging is associated with impaired scavenging of reactive oxygen species (ROS). Here, we show that TAp73, a p53 family member, protects against aging by…”
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Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation by Raymonda, Matthew H, Rodríguez-Sánchez, Irene, Schafer, Xenia L, Smorodintsev-Schiller, Leonid, Harris, Isaac S, Munger, Joshua

“…Viruses modulate host cell metabolism to support the mass production of viral progeny. For human cytomegalovirus, we find that the viral U 38 protein is…”
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TAp73 is required for spermatogenesis and the maintenance of male fertility by Inoue, Satoshi, Tomasini, Richard, Rufini, Alessandro, Elia, Andrew J., Agostini, Massimiliano, Amelio, Ivano, Cescon, Dave, Dinsdale, David, Zhou, Lily, Harris, Isaac S., Lac, Sophie, Silvester, Jennifer, Li, Wanda Y., Sasaki, Masato, Haight, Jillian, Brüstle, Anne, Wakeham, Andrew, Mckerlie, Colin, Jurisicova, Andrea, Melino, Gerry, Mak, Tak W.

“…The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal…”
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Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression by Asantewaa, Gloria, Tuttle, Emily T., Ward, Nathan P., Kang, Yun Pyo, Kim, Yumi, Kavanagh, Madeline E., Girnius, Nomeda, Chen, Ying, Rodriguez, Katherine, Hecht, Fabio, Zocchi, Marco, Smorodintsev-Schiller, Leonid, Scales, TashJaé Q., Taylor, Kira, Alimohammadi, Fatemeh, Duncan, Renae P., Sechrist, Zachary R., Agostini-Vulaj, Diana, Schafer, Xenia L., Chang, Hayley, Smith, Zachary R., O’Connor, Thomas N., Whelan, Sarah, Selfors, Laura M., Crowdis, Jett, Gray, G. Kenneth, Bronson, Roderick T., Brenner, Dirk, Rufini, Alessandro, Dirksen, Robert T., Hezel, Aram F., Huber, Aaron R., Munger, Joshua, Cravatt, Benjamin F., Vasiliou, Vasilis, Cole, Calvin L., DeNicola, Gina M., Harris, Isaac S.

“…Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the…”
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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 by Inoue, Satoshi, Hao, Zhenyue, Elia, Andrew J, Cescon, David, Zhou, Lily, Silvester, Jennifer, Snow, Bryan, Harris, Isaac S, Sasaki, Masato, Li, Wanda Y, Itsumi, Momoe, Yamamoto, Kazuo, Ueda, Takeshi, Dominguez-Brauer, Carmen, Gorrini, Chiara, Chio, Iok In Christine, Haight, Jillian, You-Ten, Annick, McCracken, Susan, Wakeham, Andrew, Ghazarian, Danny, Penn, Linda J Z, Melino, Gerry, Mak, Tak W

“…Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or…”
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Glutathione and its precursors in cancer by Asantewaa, Gloria, Harris, Isaac S

“…Buffering oxidative stress is as a crucial requirement for tumorigenesis. Antioxidant is a term reserved for molecules that quench reactive oxygen species…”
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Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis by Kang, Yun Pyo, Mockabee-Macias, Andrea, Jiang, Chang, Falzone, Aimee, Prieto-Farigua, Nicolas, Stone, Everett, Harris, Isaac S., DeNicola, Gina M.

“…Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form…”
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Regulation of cancer cell metabolism by Mak, Tak W, Cairns, Rob A, Harris, Isaac S

“…Key Points Multiple molecular mechanisms, both intrinsic and extrinsic, converge to alter core cellular metabolism and provide support for the three basic…”
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Lysosomal cystine: an unexpected alarm bell for cysteine scarcity by Hecht, Fabio, Harris, Isaac S.

“…Cells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a…”
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3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis by Takahashi, Nobuaki, Cho, Patricia, Selfors, Laura M., Kuiken, Hendrik J., Kaul, Roma, Fujiwara, Takuro, Harris, Isaac S., Zhang, Tian, Gygi, Steven P., Brugge, Joan S.

“…Cancer-associated mutations that stabilize NRF2, an oxidant defense transcription factor, are predicted to promote tumor development. Here, utilizing 3D cancer…”
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Glutathione Primes T Cell Metabolism for Inflammation by Mak, Tak W., Grusdat, Melanie, Duncan, Gordon S., Dostert, Catherine, Nonnenmacher, Yannic, Cox, Maureen, Binsfeld, Carole, Hao, Zhenyue, Brüstle, Anne, Itsumi, Momoe, Jäger, Christian, Chen, Ying, Pinkenburg, Olaf, Camara, Bärbel, Ollert, Markus, Bindslev-Jensen, Carsten, Vasiliou, Vasilis, Gorrini, Chiara, Lang, Philipp A., Lohoff, Michael, Harris, Isaac S., Hiller, Karsten, Brenner, Dirk

“…Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent…”
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