Search Results - "Harris, Dwight D"

Dipeptidyl peptidase 4 inhibitor sitagliptin decreases myocardial fibrosis and modulates myocardial insulin signaling in a swine model of chronic myocardial ischemia by Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, Stone, Chris, Bellam, Krishna, Malhotra, Akshay, Abid, M Ruhul, Sellke, Frank W

“…Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the…”
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Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium by Sabe, Sharif A, Xu, Cynthia M, Potz, Brittany A, Malhotra, Akshay, Sabra, Mohamed, Harris, Dwight D, Broadwin, Mark, Abid, M Ruhul, Sellke, Frank W

“…We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy improves myocardial function, perfusion, and angiogenesis in a swine…”
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Left Ventricular Assist Device Outflow Graft Obstruction: A Complication Specific to Polytetrafluoroethylene Covering. A Word of Caution by Alnabelsi, Talal, Shafii, Alexis E, Gurley, John C, Dulnuan, Kenneth, Harris, Dwight D, Guglin, Maya

“…Pump thrombosis is an established complication of left ventricular assist devices (LVADs). Outflow graft obstruction has been previously described as one cause…”
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Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells by Gedaly, Roberto, Cornea, Virgilius, Turcios, Lilia, Edmisson, Jacob S., Harris, Dwight D., Watt, David S., Chapelin, Fanny, Khurana, Aman, Mei, Xiaonan, Liu, Chunming, Taylor, Isaac, Gonzalez-Valdivieso, Juan, Mitchel, Hunter, Ruffing, Alexis, Chishti, Asir, Orozco, Gabriel, Zwischenberger, Joseph, Evers, B. Mark, Marti, Francesc

“…Regulatory T cells (Tregs) are essential to maintain self-tolerance and immune homeostasis but, as components of the tumor microenvironment (TME), are also a…”
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Role of Protein Kinase C in Metabolic Regulation of Coronary Endothelial Small Conductance Calcium-Activated Potassium Channels by Xing, Hang, Sabe, Sharif A, Shi, Guangbin, Harris, Dwight D, Liu, Yuhong, Sellke, Frank W, Feng, Jun

“…Small conductance calcium-activated potassium (SK) channels are largely responsible for endothelium-dependent coronary arteriolar relaxation. Endothelial SK…”
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Antineutrophil Cytoplasmic Antibody Vasculitis after Coronary Artery Bypass Grafting by Harris, Dwight D, Sabe, Sharif A, Ehsan, Afshin

“…Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of rare autoimmune disorders associated with the presence of ANCA autoantibodies…”
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DPP-4 inhibitor sitagliptin treatment results in altered myocardial metabolic proteome and oxidative phosphorylation in a swine model of chronic myocardial ischemia by Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, Bellam, Krishna, Xu, Cynthia M, Li, Janelle W, Abid, M Ruhul, Sellke, Frank W

“…Small animal models have shown improved cardiac function with DPP-4 inhibition, but many human studies have shown worse outcomes or no benefit. We seek to…”
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Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia by Broadwin, Mark, Harris, Dwight D., Sabe, Sharif A., Sengun, Elif, Sylvestre, Amber J., Alexandrov, Boian S., Sellke, Frank W., Usheva, Anny

“…Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease…”
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Crafting a Rigorous, Clinically Relevant Large Animal Model of Chronic Myocardial Ischemia: What Have We Learned in 20 Years? by Stone, Christopher R, Harris, Dwight D, Broadwin, Mark, Kanuparthy, Meghamsh, Sabe, Sharif A, Xu, Cynthia, Feng, Jun, Abid, M Ruhul, Sellke, Frank W

“…The past several decades have borne witness to several breakthroughs and paradigm shifts within the field of cardiovascular medicine, but one component that…”
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Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia by Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, Stone, Christopher, Xu, Cynthia, Hu, Jiayu, Kanuparthy, Meghamsh, Abid, M Ruhul, Sellke, Frank W

“…Sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to be cardioprotective independent of glucose control, but the mechanisms of these benefits are…”
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Intramyocardial Injection of Hypoxia-Conditioned Extracellular Vesicles Modulates Response to Oxidative Stress in the Chronically Ischemic Myocardium by Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, Xu, Cynthia, Stone, Christopher, Kanuparthy, Meghamsh, Malhotra, Akshay, Abid, M Ruhul, Sellke, Frank W

“…Patients with advanced coronary artery disease (CAD) who are not eligible for stenting or surgical bypass procedures have limited treatment options…”
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Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile by Sabe, Sharif A., Xu, Cynthia M., Sabra, Mohamed, Harris, Dwight D., Broadwin, Mark, Bellam, Krishna G., Banerjee, Debolina, Usheva, Anny, Abid, M. Ruhul, Sellke, Frank W.

“…Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK…”
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Extracorporeal membrane oxygenation as a rescue measure after thoracic surgery by Harris, Dwight D, Saha, Sibu P

“…Background Extracorporeal membrane oxygenation is used for many different conditions including respiratory distress, cardiogenic shock, and trauma. In these…”
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Increased blood transfusion and its impact in patients having tracheostomy while on extracorporeal membrane oxygenation by Harris, Dwight D., Shafii, Alexis E., Baz, Maher, Tribble, Thomas A., Ferraris, Victor A.

“…Introduction: Tracheostomy has been utilized in combination with venovenous extracorporeal membrane oxygenation (VV-ECMO) to enable early spontaneous breathing…”
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Cardioprotection in cardiovascular surgery by Sabe, Sharif A., Harris, Dwight D., Broadwin, Mark, Sellke, Frank W.

“…Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic injury to the heart during aortic…”
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Gender, race, and ethnicity in lung cancer clinical trial participation: Analysis of 253,845 patients from 2002 to 2021 by Kanuparthy, Meghamsh, Kanuparthy, Srikur, Harris, Dwight D., Broadwin, Mark, Stone, Christopher, Abbas, Abbas E., Sellke, Frank W.

“…Lung cancer remains the greatest cause of cancer-related death, and multiple large studies have identified persistent racial disparities in lung cancer…”
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Metformin Preconditioning Augments Cardiac Perfusion and Performance in a Large Animal Model of Chronic Coronary Artery Disease by Stone, Christopher, Sabe, Sharif, Harris, Dwight D, Broadwin, Mark, Kant, Rajeev, Kanuparthy, Meghamsh, Abid, M Ruhul, Sellke, Frank W

“…To test the efficacy of metformin during the induction of coronary ischemia on myocardial performance in a large animal model of coronary artery disease (CAD)…”
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Effects of diet-induced metabolic syndrome on cardiac function and angiogenesis in response to the sodium-glucose cotransporter-2 inhibitor canagliflozin by Harris, Dwight D., Broadwin, Mark, Sabe, Sharif A., Stone, Chris, Kanuparthy, Meghamsh, Nho, Ju-Woo, Bellam, Krishna, Banerjee, Debolina, Abid, M. Ruhul, Sellke, Frank W.

“…Sodium-glucose cotransporter-2 inhibitors are antidiabetic medications that have been shown to decrease cardiovascular events and heart failure-related…”
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Proteomic Analysis and Sex-Specific Changes in Chronically Ischemic Swine Myocardium Treated with Sodium-Glucose Cotransporter-2 Inhibitor Canagliflozin by Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, Stone, Christopher, Malhotra, Akshay, Xu, Cynthia M, Sabra, Mohamed, Abid, M Ruhul, Sellke, Frank W

“…Although sodium-glucose cotransporter-2 inhibitors have been shown to improve cardiovascular outcomes in general, little is presently known about any…”
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Canagliflozin improves coronary microvascular vasodilation and increases absolute blood flow to the myocardium independent of angiogenesis by Banerjee, Debolina, Sabe, Sharif A, Xing, Hang, Xu, Cynthia, Sabra, Mohamed, Harris, Dwight D, Broadwin, Mark, Abid, M Ruhul, Usheva, Anny, Feng, Jun, Sellke, Frank W

“…Sodium-glucose cotransporter-2 inhibitor, canagliflozin, improves myocardial perfusion to ischemic territory without accompanying changes in vascular density…”
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