Search Results - "Harris, Christina R."

A simplified methodology for the activation of organic charcoal by Nelson, Stephen, Hare, Connor, Mpyisi, Atieno, Yew, Chen Wei, LeBrun, Kendra, Harris, Christina R., Feese, Berquin D., Celestine, Ronald, Kinjo, Masato, Peacock, John S.

“…One in three people globally are challenged to live on hazardous, unsanitary water, and this relates to higher risks of death and development of diseases…”
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Desoxyepothilone B is Curative against Human Tumor Xenografts that are Refractory to Paclitaxel by Chou, Ting-Chao, Zhang, Xiu-Guo, Harris, Christina R., Kuduk, Scott D., Balog, Aaron, Savin, Kenneth A., Bertino, Joseph R., Danishefsky, Samuel J.

“…The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although structurally dissimilar, both…”
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Sequencing Reactions with Samarium(II) Iodide by Molander, Gary A, Harris, Christina R

“…Molander and Harris highlight the use of samarium(II) iodide (SmI2) in each class of sequential, or tandem, organic reactions. The review covers published…”
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Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones by Wagman, Allan S., Cirz, Ryan, McEnroe, Glenn, Aggen, James, Linsell, Martin S., Goldblum, Adam A., Lopez, Sara, Gomez, Marcela, Miller, George, Simons, Lloyd J., Belliotti, Thomas R., Harris, Christina R., Poel, Toni‐Jo, Melnick, Michael J., Gaston, Ricky D., Moser, Heinz E.

“…Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a…”
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Cover Feature: Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (ChemMedChem 20/2017) by Wagman, Allan S., Cirz, Ryan, McEnroe, Glenn, Aggen, James, Linsell, Martin S., Goldblum, Adam A., Lopez, Sara, Gomez, Marcela, Miller, George, Simons, Lloyd J., Belliotti, Thomas R., Harris, Christina R., Poel, Toni‐Jo, Melnick, Michael J., Gaston, Ricky D., Moser, Heinz E.

“…The Cover Feature shows the conceptual conversion of clinafloxacin to its tetracyclic analog by addition of a 7‐membered ring, thereby conformationally fixing…”
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Complex Target-Oriented Synthesis in the Drug Discovery Process:  A Case History in the dEpoB Series by Danishefsky, Samuel J

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Pursuit of Optimal Carbohydrate-Based Anticancer Vaccines:  Preparation of a Multiantigenic Unimolecular Glycopeptide Containing the Tn, MBr1, and Lewisy Antigens by Allen, Jennifer R, Harris, Christina R, Danishefsky, Samuel J

“…A novel preparation of nonnatural glycoamino acids starting from n-pentenyl glycosides is described. The approach involves a Horner−Emmons olefination with a…”
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Advances in the discovery of novel antibacterial agents during the year 2002 by Harris, Christina R, Thorarensen, Atli

“…The development of bacterial resistance is a significant problem in the treatment of infection, and the importance of research directed toward the discovery of…”
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Conjugate Addition Reactions Mediated by Samarium(II) Iodide by Molander, Gary A, Harris, Christina R

“…Samarium(II) iodide in conjunction with a catalytic low-valent transition metal species has been employed to promote the conjugate addition reaction of primary…”
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Six-membered cyclic .beta.-keto esters by tandem conjugate addition-Dieckmann condensation reactions by Bunce, Richard A, Harris, Christina R

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New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol Condensation by Harris, Christina R, Kuduk, Scott D, Balog, Aaron, Savin, Ken, Glunz, Peter W, Danishefsky, Samuel J

“…The epothilones are naturally occurring cytotoxic molecules that possess the remarkable ability to arrest cell division through the stabilization of…”
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Synthesis and evaluation of geldanamycin-testosterone hybrids by KUDUK, S. D, HARRIS, C. R, ZHENG, F. F, SEPP-LORENZINO, L, OUERFELLI, Q, ROSEN, N, DANISHEFSKY, S. J

“…Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM-testosterone…”
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Sequenced Reactions with Samarium(II) Iodide. Tandem Intramolecular Nucleophilic Acyl Substitution/Intramolecular Barbier Cyclizations by Molander, Gary A, Harris, Christina R

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Sequenced Reactions with Samarium(II) Iodide. Tandem Nucleophilic Acyl Substitution/Ketyl−Olefin Coupling Reactions by Molander, Gary A, Harris, Christina R

“…Samarium(II) iodide has been employed to promote a tandem intramolecular nucleophilic acyl substitution/intramolecular ketyl−olefin coupling cyclization…”
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Sequenced Reactions with Samarium(II) Iodide. Sequential Nucleophilic Acyl Substitution/Ketyl Olefin Coupling Reactions for the Preparation of Oxygen Heterocycles by Molander, Gary A, Harris, Christina R

“…Samarium(II) iodide has been employed to promote a sequential intramolecular nucleophilic acyl substitution/intramolecular ketyl olefin coupling cyclization…”
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Probing the SAR of dEpoB via Chemical Synthesis:  A Total Synthesis Evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B by Chappell, Mark D, Harris, Christina R, Kuduk, Scott D, Balog, Aaron, Wu, Zhicai, Zhang, Fei, Lee, Chul Bom, Stachel, Shawn J, Danishefsky, Samuel J, Chou, Ting-Chao, Guan, Yongbiao

“…A practical total synthesis of 26-(1,3-dioxolanyl)-12,13-desoxyepothilone B (26-dioxolanyl dEpoB) was accomplished in a highly convergent manner. A novel…”
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Sequential Ketyl−Olefin Coupling/β-Elimination Reactions Mediated by Samarium(II) Iodide by Molander, Gary A, Harris, Christina R

“…Samarium(II) iodide (SmI2) has been employed in an intramolecular sequential ketyl−olefin coupling/β-elimination reaction. The overall process results in the…”
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Sequential Nucleophilic Acyl Substitution/Alkenyl Transfer Reactions Mediated by Samarium(II) Iodide by Molander, Gary A, Harris, Christina R

“…Samarium(II) iodide (SmI2) has been employed in a one-pot, three-step, nucleophilic acyl substitution/ketyl−olefin coupling/β-elimination reaction sequence…”
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In pursuit of an anticancer vaccine: a monomolecular construct containing multiple carbohydrate antigens by Williams, Lawrence J, Harris, Christina R, Glunz, Peter W, Danishefsky, Samuel J

“…The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le y, and Tn tumor antigens clustered in a…”
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Remarkable long range effects on the diastereoface selectivity in an aldol condensation by Harris, Christina R, Kuduk, Scott D, Balog, Aaron, Savin, Ken A, Danishefsky, Samuel J

“…The stereochemical results in an aldol reaction between the enolate 2 and various α-methyl aldehydes indicates a stabilizing through space interaction between…”
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