Search Results - "Harris, Audray K."
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Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies
Published in Nature communications (30-03-2023)“…Influenza virus infects millions of people annually and can cause global pandemics. Hemagglutinin (HA) is the primary component of commercial influenza…”
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Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies
Published in Proceedings of the National Academy of Sciences - PNAS (19-03-2013)“…Rapid antigenic variation of HA, the major virion surface protein of influenza A virus, remains the principal challenge to the development of broader and more…”
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Impact of adjuvant: Trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus
Published in Frontiers in immunology (30-09-2022)“…As new vaccine technologies and platforms, such as nanoparticles and novel adjuvants, are developed to aid in the establishment of a universal influenza…”
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Structural analysis of influenza vaccine virus-like particles reveals a multicomponent organization
Published in Scientific reports (09-07-2018)“…Influenza virus continues to be a major health problem due to the continually changing immunodominant head regions of the major surface glycoprotein,…”
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Corrigendum: Impact of adjuvant: trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus
Published in Frontiers in immunology (12-09-2023)Get full text
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Negative-Stain Transmission Electron Microscopy of Molecular Complexes for Image Analysis by 2D Class Averaging
Published in Current protocols in microbiology (Online) (01-09-2019)“…Negative-stain transmission electron microscopy (EM) is a technique that has provided nanometer resolution images of macromolecules for about 60 years…”
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HIV-1 Envelope Glycoprotein Trimers Display Open Quaternary Conformation When Bound to the gp41 Membrane-Proximal External-Region-Directed Broadly Neutralizing Antibody Z13e1
Published in Journal of Virology (01-06-2013)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of Hemagglutinin Antigens on Influenza Virus and within Vaccines Using Electron Microscopy
Published in Vaccines (Basel) (25-05-2018)“…Influenza viruses affect millions of people worldwide on an annual basis. Although vaccines are available, influenza still causes significant human mortality…”
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Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
Published in Nature medicine (01-09-2015)“…Barney Graham and colleagues have developed a hemagglutinin stem–based nanoparticle as a vaccine that confers protection against different influenza strains in…”
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Cryo-EM cools down swine fever
Published in The Journal of biological chemistry (03-01-2020)“…African swine fever virus (ASFV) is among the most complex DNA viruses known. Outbreaks have killed millions of swine around the world, and there is currently…”
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Structural studies of influenza virus RNPs by electron microscopy indicate molecular contortions within NP supra-structures
Published in Journal of structural biology (01-03-2017)“…Ribonucleoprotein (RNP) complexes of influenza viruses are composed of multiple copies of the viral nucleoprotein (NP) that can form filamentous…”
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Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes
Published in PLoS pathogens (28-08-2023)“…Despite the availability of seasonal vaccines and antiviral medications, influenza virus continues to be a major health concern and pandemic threat due to the…”
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Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform
Published in Virology (New York, N.Y.) (01-02-2017)“…Abstract While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on…”
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Characterization of Influenza Vaccine Hemagglutinin Complexes by Cryo-Electron Microscopy and Image Analyses Reveals Structural Polymorphisms
Published in Clinical and vaccine immunology (01-06-2016)“…Influenza virus afflicts millions of people worldwide on an annual basis. There is an ever-present risk that animal viruses will cross the species barrier to…”
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Immunoelectron Microscopy of Viral Antigens
Published in Current protocols in microbiology (Online) (01-06-2019)“…Immunoelectron microscopy is a powerful technique for identifying viral antigens and determining their structural localization and organization within vaccines…”
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Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Published in Nature immunology (01-06-2019)“…In the version of this article initially published, the labels (50 Å) above the scale bars in Fig. 1b were incorrect. The correct size is 50 nm. The error has…”
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Cryo-EM cools down swine fever
Published in The Journal of biological chemistry (03-01-2020)“…African swine fever virus (ASFV) is among the most complex DNA viruses known. Outbreaks have killed millions of swine around the world, and there is currently…”
Get full text
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Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses
Published in Immunity (Cambridge, Mass.) (13-12-2022)“…Current influenza vaccines predominantly induce immunity to the hypervariable hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conversely,…”
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Molecular Structures of Native HA Trimers on 2009 H1N1 Pandemic Influenza Virus Complexed with Neutralizing Antibodies
Published in Biophysical journal (29-01-2013)Get full text
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