Search Results - "Harrington, Susan"

Population Health: A New Essential in Nursing by Harrington, Susan A.

“…Nursing education is engaged in efforts to respond and adapt to the dynamic fluctuations of health care in the United States. Population health has been…”
Get full text

PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression by Tang, Haidong, Liang, Yong, Anders, Robert A, Taube, Janis M, Qiu, Xiangyan, Mulgaonkar, Aditi, Liu, Xin, Harrington, Susan M, Guo, Jingya, Xin, Yangchun, Xiong, Yahong, Nham, Kien, Silvers, William, Hao, Guiyang, Sun, Xiankai, Chen, Mingyi, Hannan, Raquibul, Qiao, Jian, Dong, Haidong, Peng, Hua, Fu, Yang-Xin

“…Programmed death-ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment, and PD-L1 blockade therapy has shown unprecedented durable…”
Get full text

PD-1 Restrains Radiotherapy-Induced Abscopal Effect by Park, Sean S, Dong, Haidong, Liu, Xin, Harrington, Susan M, Krco, Christopher J, Grams, Michael P, Mansfield, Aaron S, Furutani, Keith M, Olivier, Kenneth R, Kwon, Eugene D

“…We investigated the influence of PD-1 expression on the systemic antitumor response (abscopal effect) induced by stereotactic ablative radiotherapy (SABR) in…”
Get more information

Immune checkpoint molecules soluble program death ligand 1 and galectin‐9 are increased in pregnancy by Enninga, Elizabeth Ann L., Harrington, Susan M., Creedon, Douglas J., Ruano, Rodrigo, Markovic, Svetomir N., Dong, Haidong, Dronca, Roxana S.

“…Problem Pregnancy requires balance between tolerance to the haploidentical fetus and the mother's ability to mount immune responses. There are parallels to…”
Get full text

B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis by Mansfield, Aaron Scott, Roden, Anja C, Peikert, Tobias, Sheinin, Yuri M, Harrington, Susan M, Krco, Christopher J, Dong, Haidong, Kwon, Eugene D

“…B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types…”
Get more information

A Comparison of Five SARS-CoV-2 Molecular Assays With Clinical Correlations by Procop, Gary W, Brock, Jay E, Reineks, Edmunds Z, Shrestha, Nabin K, Demkowicz, Ryan, Cook, Eleanor, Ababneh, Emad, Harrington, Susan M

“…Abstract Objectives Comparative assessments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular assays that have been operationalized…”
Get full text

PD-L1 expression in triple-negative breast cancer by Mittendorf, Elizabeth A, Philips, Anne V, Meric-Bernstam, Funda, Qiao, Na, Wu, Yun, Harrington, Susan, Su, Xiaoping, Wang, Ying, Gonzalez-Angulo, Ana M, Akcakanat, Argun, Chawla, Akhil, Curran, Michael, Hwu, Patrick, Sharma, Padmanee, Litton, Jennifer K, Molldrem, Jeffrey J, Alatrash, Gheath

“…Early-phase trials targeting the T-cell inhibitory molecule programmed cell death ligand 1 (PD-L1) have shown clinical efficacy in cancer. This study was…”
Get more information

Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction by Zhu, Mojun, Chen, Chunhua, Foster, Nathan R, Hartley, Christopher, Mounajjed, Taofic, Salomao, Marcela A, Fruth, Briant F, Beamer, Staci E, Kim, Yohan, Harrington, Susan M, Pitot, Henry C, Sanhueza, Cristobal T, Feng, Yening, Herrmann, Joerg, McWilliams, Robert R, Lucien, Fabrice, Huang, Bing Q, Ma, Wen Wee, Bekaii-Saab, Tanios S, Dong, Haidong, Wigle, Dennis, Ahn, Daniel H, Hallemeier, Chris L, Blackmon, Shanda, Yoon, Harry H

“…This phase Ib/2 trial investigated pembrolizumab-containing trimodality therapy in patients with gastroesophageal junction (GEJ) adenocarcinoma. Patients with…”
Get full text

Tumor B7-H1 and B7-H3 Expression in Squamous Cell Carcinoma of the Lung by Boland, Jennifer M, Kwon, Eugene D, Harrington, Susan M, Wampfler, Jason A, Tang, Hui, Yang, Ping, Aubry, Marie Christine

“…Micro-Abstract Aberrant expression of immunomodulatory proteins B7-H1 and B7-H3 by malignant cells may contribute to tumoral immune evasion…”
Get full text

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance by Orme, Jacob J., Jazieh, Khalid A., Xie, Tiancheng, Harrington, Susan, Liu, Xin, Ball, Matthew, Madden, Benjamin, Charlesworth, M. Cristine, Azam, Tariq U., Lucien, Fabrice, Wootla, Bharath, Li, Yanli, Villasboas, Jose Caetano, Mansfield, Aaron S., Dronca, Roxana S., Dong, Haidong

“…ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The…”
Get full text

B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8+ T cells by Liu, Xin, Wu, Xiaosheng, Cao, Siyu, Harrington, Susan M., Yin, Peng, Mansfield, Aaron S., Dong, Haidong

“…B7-H1 (aka PD-L1) blocking antibodies have been used in treatment of human cancers through blocking B7-H1 expressed by tumor cells; however, their impact on…”
Get full text

Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trial by Hieken, Tina J., Nelson, Garth D., Flotte, Thomas J., Grewal, Eric P., Chen, Jun, McWilliams, Robert R., Kottschade, Lisa A., Yang, Lu, Domingo-Musibay, Evidio, Dronca, Roxana S., Yan, Yiyi, Markovic, Svetomir N., Dimou, Anastasios, Montane, Heather N., Erskine, Courtney L., Piltin, Mara A., Price, Daniel L., Khariwala, Samir S., Hui, Jane, Strand, Carrie A., Harrington, Susan M., Suman, Vera J., Dong, Haidong, Block, Matthew S.

“…Both targeted therapies and immunotherapies provide benefit in resected Stage III melanoma. We hypothesized that the combination of targeted and immunotherapy…”
Get full text

Non-invasive immunoPET imaging of PD-L1 using anti-PD-L1-B11 in breast cancer and melanoma tumor model by Bansal, Aditya, Pandey, Mukesh K., Barham, Whitney, Liu, Xin, Harrington, Susan M., Lucien, Fabrice, Dong, Haidong, Park, Sean S., DeGrado, Timothy R.

“…Immunotherapy targeting PD-1/PD-L1 immune checkpoint inhibition (ICI) is efficacious in various solid and hematologic malignancies. However, the response rate…”
Get full text

CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy by Yan, Yiyi, Cao, Siyu, Liu, Xin, Harrington, Susan M, Bindeman, Wendy E, Adjei, Alex A, Jang, Jin Sung, Jen, Jin, Li, Ying, Chanana, Pritha, Mansfield, Aaron S, Park, Sean S, Markovic, Svetomir N, Dronca, Roxana S, Dong, Haidong

“…Although immune checkpoint inhibitors have resulted in durable clinical benefits in a subset of patients with advanced cancer, some patients who did not…”
Get full text

A Novel PD-L1 Antibody Promotes Antitumor Function of Peripheral Cytotoxic Lymphocytes after Radical Nephrectomy in Patients with Renal Cell Carcinoma by An, Zesheng, Hsu, Michelle A, Gicobi, Joanina K, Xu, Tianxiao, Harrington, Susan M, Zhang, Henan, Pavelko, Kevin D, Hirdler, Jacob B, Lohse, Christine M, Nabavizadeh, Reza, Pessoa, Rodrigo R, Sharma, Vidit, Thompson, R Houston, Leibovich, Bradley C, Dong, Haidong, Lucien, Fabrice

“…The intrinsic and acquired resistance to PD-1/PD-L1 immune checkpoint blockade is an important challenge for patients and clinicians because no reliable tool…”
Get full text

Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels by Sideras, Kostandinos, de Man, Robert A., Harrington, Susan M., Polak, Wojciech G., Zhou, Guoying, Schutz, Hannah M., Pedroza-Gonzalez, Alexander, Biermann, Katharina, Mancham, Shanta, Hansen, Bettina E., Bart Takkenberg, R., van Vuuren, Anneke J., Pan, Qiuwei, Ijzermans, Jan N. M., Sleijfer, Stefan, Sprengers, Dave, Dong, Haidong, Kwekkeboom, Jaap, Bruno, Marco J.

“…Tumor expression of immune co-inhibitory ligands, such as PD-L1 and Galectin-9, have potential prognostic value in Hepatocellular Carcinoma (HCC). Circulating…”
Get full text

Pic Protease of Enteroaggregative Escherichia coli Promotes Intestinal Colonization and Growth in the Presence of Mucin by Harrington, Susan M, Sheikh, Jalaluddin, Henderson, Ian R, Ruiz-Perez, Fernando, Cohen, Paul S, Nataro, James P

“…Enteroaggregative Escherichia coli (EAEC) is increasingly being recognized as a cause of diarrheal disease in diverse populations. No small animal model is…”
Get full text

Multicenter Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Study for Identification of Clinically Relevant Nocardia spp by Blosser, Sara J, Drake, Steven K, Andrasko, Jennifer L, Henderson, Christina M, Kamboj, Kamal, Antonara, Stella, Mijares, Lilia, Conville, Patricia, Frank, Karen M, Harrington, Susan M, Balada-Llasat, Joan-Miquel, Zelazny, Adrian M

“…This multicenter study analyzed Nocardia spp., including extraction, spectral acquisition, Bruker matrix-assisted laser desorption ionization-time of flight…”
Get full text

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1 by Yin, Peng, Liu, Xin, Mansfield, Aaron S, Harrington, Susan M, Li, Yinghua, Yan, Yiyi, Dong, Haidong

“…CpG oligodeoxynucleotides, as a ligand of toll-like receptor (TLR)-9, have demonstrated promising antitumor effects in some clinical trials; however, its…”
Get full text

Lawsonella clevelandensis gen. nov., sp. nov., a new member of the suborder Corynebacterineae isolated from human abscesses by Bell, Melissa E, Bernard, Kathryn A, Harrington, Susan M, Patel, Nisha B, Tucker, Trudy-Ann, Metcalfe, Maureen G, McQuiston, John R

“…Gram-stain-positive, partially acid-fast, non-spore-forming, anaerobic, catalase-positive, pleomorphic bacteria were isolated from human abscesses. Strains…”
Get full text