Search Results - "Harrington, LS"

Restraining PI3K: mTOR signalling goes back to the membrane by Harrington, Laura S., Findlay, Greg M., Lamb, Richard F.

“…The lipid kinase phosphoinositide 3-kinase (PI3K) is activated in response to various extracellular signals including peptide growth factors such as insulin…”
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The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins by Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.

“…Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses…”
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P2X1 receptors and the endothelium by Harrington, L S, Mitchell, J A

“…Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated…”
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Novel role for P2X receptor activation in endothelium‐dependent vasodilation by Harrington, Louise S, Mitchell, Jane A

“…ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y. Activation of P2X receptors has traditionally been associated with…”
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Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll‐like receptor 4 responses in macrophages by Moreno, L, McMaster, SK, Gatheral, T, Bailey, LK, Harrington, LS, Cartwright, N, Armstrong, PCJ, Warner, TD, Paul‐Clark, M, Mitchell, JA

“…Background and purpose:  Gram‐negative bacteria contain ligands for Toll‐like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors…”
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TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation? by Findlay, Greg M, Harrington, Laura S, Lamb, Richard F

“…Understanding the relationship between growth and proliferation in multicellular organisms requires identification of the key regulators of growth control, and…”
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Not so EEZE: the ‘EDHF’ antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries by Harrington, Louise S., Falck, John R., Mitchell, Jane A.

“…P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study,…”
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Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats by SACK, M. N, HARRINGTON, L. S, JONASSEN, A. K, MJØS, O. D, YELLON, D. M

“…Fuel substrate utilization is highly regulated during cardiac development and with the onset of cardiac hypertrophy. Glucose and lactate are the predominant…”
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Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease by Schegg, K M, Harrington, L S, Neilsen, S, Zweig, R M, Peacock, J H

“…In order to determine the effect of Alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase…”
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