Determination of the dosage of clomipramine for the treatment of urine spraying in cats

To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Randomized controlled multicenter clinical trial. 67 neutered cats. Cats with a minimum 1-month history of spraying urine against vertical surfaces at least twice per week were randomly assigned to be treate...

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Bibliographic Details
Published in:	Journal of the American Veterinary Medical Association Vol. 225; no. 6; pp. 881 - 887
Main Authors:	King, J.N, Steffan, J, Heath, S.E, Simpson, B.S, Crowell-Davis, S.L, Harrington, L.J.M, Weiss, A.B, Seewald, W
Format:	Journal Article
Language:	English
Published:	United States 15-09-2004
Subjects:	Administration, Oral Animals Behavior, Animal - drug effects Castration - veterinary Cat Diseases - drug therapy Cats Clomipramine - therapeutic use Dose-Response Relationship, Drug Drug Administration Schedule - veterinary Female Male Random Allocation Serotonin Uptake Inhibitors - therapeutic use Treatment Outcome Urination Disorders - drug therapy Urination Disorders - veterinary
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Summary:	To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Randomized controlled multicenter clinical trial. 67 neutered cats. Cats with a minimum 1-month history of spraying urine against vertical surfaces at least twice per week were randomly assigned to be treated with a placebo or with clomipramine at a dosage of 0.125 to 0.25 mg/kg (0.057 to 0.11 mg/lb), 0.25 to 0.5 mg/kg (0.11 to 0.23 mg/lb), or 0.5 to 1 mg/kg (0.23 to 0.45 mg/lb), p.o., every 24 hours for up to 12 weeks. Owners of all cats were given information on behavioral treatment and environmental modification. Prior to treatment, mean number of urine spraying events ranged from 0.9 to 1.3 urine spraying events/d for the 4 groups, and mean percentage of days with urine spraying events ranged from 62% to 69%. All 3 dosages of clomipramine were associated with significant reductions in frequency of urine spraying. Sedation was the most common adverse effect and was identified in 27 of the 50 cats treated with clomipramine; however, treatment was not discontinued in any cat because of sedation. Results of the present study suggest that compared with a placebo, clomipramine significantly reduces the frequency of urine spraying in cats in terms of the number of urine spraying events per day and the number of days with urine spraying events. For cats with urine spraying, the recommended initial dosage of clomipramine is 0.25 to 0.5 mg/kg, p.o., every 24 hours.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-1488 1943-569X
DOI:	10.2460/javma.2004.225.881