Search Results - "Harrington, B"

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity by Chen, Janice S, Ma, Enbo, Harrington, Lucas B, Da Costa, Maria, Tian, Xinran, Palefsky, Joel M, Doudna, Jennifer A

“…CRISPR-Cas12a (Cpf1) proteins are RNA-guided enzymes that bind and cut DNA as components of bacterial adaptive immune systems. Like CRISPR-Cas9, Cas12a has…”
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Enhanced proofreading governs CRISPR–Cas9 targeting accuracy by Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.

“…A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target…”
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Programmed DNA destruction by miniature CRISPR-Cas14 enzymes by Harrington, Lucas B, Burstein, David, Chen, Janice S, Paez-Espino, David, Ma, Enbo, Witte, Isaac P, Cofsky, Joshua C, Kyrpides, Nikos C, Banfield, Jillian F, Doudna, Jennifer A

“…CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids and are widely employed as genome editing tools. These tools use…”
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A thermostable Cas9 with increased lifetime in human plasma by Harrington, Lucas B., Paez-Espino, David, Staahl, Brett T., Chen, Janice S., Ma, Enbo, Kyrpides, Nikos C., Doudna, Jennifer A.

“…CRISPR-Cas9 is a powerful technology that has enabled genome editing in a wide range of species. However, the currently developed Cas9 homologs all originate…”
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A Sensitive and Selective Electrochemical Sensor Based on Graphene Quantum Dot/Gold Nanoparticle Nanocomposite Modified Electrode for the Determination of Quercetin in Biological Samples by Li, Jianjun, Qu, Jiajia, Yang, Ran, Qu, Lingbo, de B. Harrington, Peter

“…A simple and sensitive electrochemical sensor based on (graphene quantum dot)/(gold nanoparticle) nanocomposite (GQD/AuNP) modified glassy carbon electrode…”
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Metabolomic profiling and comparison of major cinnamon species using UHPLC–HRMS by Wang, Yifei, Harrington, Peter de B., Chen, Pei

“…The metabolomic profiles of four major species of cinnamon ( Cinnamomum verum , C. burmannii , C. loureiroi , and C. cassia ) were investigated by…”
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Variability in practice and factors predictive of total crystalloid administration during abdominal surgery: retrospective two-centre analysis by Lilot, M., Ehrenfeld, J.M., Lee, C., Harrington, B., Cannesson, M., Rinehart, J.

“…Variation in clinical practice in the perioperative environment and intensive care unit is a major challenge facing modern medicine. The objective of the…”
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Analysis of cranberry proanthocyanidins using UPLC–ion mobility–high-resolution mass spectrometry by Wang, Yifei, de B. Harrington, Peter, Chang, Tony, Wu, Xianli, Chen, Pei

“…Cranberry proanthocyanidin oligomers were investigated using ultra performance liquid chromatography–ion mobility–high-resolution mass spectrometry…”
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A Literature Synthesis of Health Promotion Research in Salons and Barbershops by Linnan, Laura A., ScD, D’Angelo, Heather, MHS, Harrington, Cherise B., PhD

“…Context Barbershops and beauty salons are located in all communities and frequented by diverse groups of people, making them key settings for addressing health…”
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CRISPR Immunological Memory Requires a Host Factor for Specificity by Nuñez, James K., Bai, Lawrence, Harrington, Lucas B., Hinder, Tracey L., Doudna, Jennifer A.

“…Bacteria and archaea employ adaptive immunity against foreign genetic elements using CRISPR-Cas systems. To generate immunological memory, the Cas1-Cas2…”
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Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer by Wang, Ling, Vendrell-Dones, Mario O., Deriu, Chiara, Doğruer, Sevde, de B. Harrington, Peter, McCord, Bruce

“…Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy…”
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Quantitative analysis of proanthocyanidins in cocoa using cysteamine-induced thiolysis and reversed-phase UPLC by Wang, Yifei, Harrington, Peter de B., Chen, Pei

“…The thiolysis of B-type proanthocyanidins in cocoa by cysteamine was evaluated and optimized for its application in cocoa proanthocyanidin quantification. Four…”
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Renin–Angiotensin–Aldosterone System Inhibitors and COVID-19 Infection or Hospitalization: A Cohort Study by Dublin, Sascha, Walker, Rod L, Floyd, James S, Shortreed, Susan M, Fuller, Sharon, Albertson-Junkans, Ladia, Harrington, Laura B, Greenwood-Hickman, Mikael Anne, Green, Beverly B, Psaty, Bruce M

“…Abstract Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of coronavirus disease 2019…”
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Analysis of phenolic compositions in cranberry dietary supplements using UHPLC-HRMS by Wang, Yifei, de B. Harrington, Peter, Chen, Pei

“…•Ten cranberry dietary supplements were evaluated by their phenolic profiles.•Quercetin and myricetin aglycones were found in most supplements, not fruits.•All…”
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Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM by Sun, Ming, Azumaya, Caleigh M., Tse, Eric, Bulkley, David P., Harrington, Matthew B., Gilbert, Glenn, Frost, Adam, Southworth, Daniel, Verba, Kliment A., Cheng, Yifan, Agard, David A.

“…[Display omitted] •Exploring cryo-EM data collection strategies with focus using CDS mode on the Gatan K3 camera.•Gatan K3 operating in CDS mode outperformed…”
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Electrospray Ionization Ion Mobility Mass Spectrometry by Kohoutek, Katie M., Harrington, Peter de B.

“…Electrospray ionization ion mobility mass spectrometry (ESI-IMS-MS) is a rapidly progressing analytical technique for the examination of complex compounds in…”
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Sensitive voltammetric sensor based on Isopropanol–Nafion–PSS–GR nanocomposite modified glassy carbon electrode for determination of Clenbuterol in pork by Wang, Ling, Yang, Ran, Chen, Jing, Li, Jianjun, Qu, Lingbo, de B. Harrington, Peter

“…•PSS functionalized graphene (GR) was synthesized via one-step chemical reduction.•PSS–GR exhibited high electrocatalytic activity towards the oxidation of…”
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Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism by Oancea, I, Movva, R, Das, I, Aguirre de Cárcer, D, Schreiber, V, Yang, Y, Purdon, A, Harrington, B, Proctor, M, Wang, R, Sheng, Y, Lobb, M, Lourie, R, Ó Cuív, P, Duley, J A, Begun, J, Florin, T H J

“…Mercaptopurine (MP) and pro-drug azathioprine are 'first-line' oral therapies for maintaining remission in IBD. It is believed that their pharmacodynamic…”
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An ultrasensitive chemiluminescence immunoassay for fumonisin B1 detection in cereals based on gold‐coated magnetic nanoparticles by Jie, Mingsha, Yu, Songcheng, Yu, Fei, Liu, Lie, He, Leiliang, Li, Yanqiang, Zhang, Hongquan, Qu, Lingbo, Harrington, Peter de B, Wu, Yongjun

“…BACKGROUND In the present study, a novel highly sensitive magnetic enzyme chemiluminescence immunoassay (MECLIA) was developed to detect fumonisin B1 (FB1) in…”
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Comparison of Three Algorithms for the Baseline Correction of Hyphenated Data Objects by Wang, Zhengfang, Zhang, Mengliang, Harrington, Peter de B

“…Three novel two-way baseline correction algorithms, that is, orthogonal basis (OB), fuzzy optimal associative memory (FOAM), and polynomial fitting (PF), were…”
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