Search Results - "Harrington, Anthony W."

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO by Gu, Shenyan, Matta, Jose A., Lord, Brian, Harrington, Anthony W., Sutton, Steven W., Davini, Weston B., Bredt, David S.

“…Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling…”
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Recruitment of Actin Modifiers to TrkA Endosomes Governs Retrograde NGF Signaling and Survival by Harrington, Anthony W., St. Hillaire, Coryse, Zweifel, Larry S., Glebova, Natalia O., Philippidou, Polyxeni, Halegoua, Simon, Ginty, David D.

“…The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF…”
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Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids by Woodruff, Grace, Phillips, Naomi, Carromeu, Cassiano, Guicherit, Oivin, White, Alistair, Johnson, McCay, Zanella, Fabian, Anson, Blake, Lovenberg, Timothy, Bonaventure, Pascal, Harrington, Anthony W

“…Human induced Pluripotent Stem Cells (iPSCs) are a powerful tool to dissect the biology of complex human cell types such as those of the central nervous system…”
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NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain by Matta, Jose A., Gu, Shenyan, Davini, Weston B., Lord, Brian, Siuda, Edward R., Harrington, Anthony W., Bredt, David S.

“…Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of…”
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The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels by Woodruff, Grace, Bouwkamp, Christian G, de Vrij, Femke M, Lovenberg, Timothy, Bonaventure, Pascal, Kushner, Steven A, Harrington, Anthony W

“…Zinc homeostasis is a highly regulated process in mammalian cells that is critical for normal growth and development. Movement of zinc across cell compartments…”
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Long-Distance Control of Synapse Assembly by Target-Derived NGF by Sharma, Nikhil, Deppmann, Christopher D., Harrington, Anthony W., St. Hillaire, Coryse, Chen, Zhe-Yu, Lee, Francis S., Ginty, David D.

“…We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is…”
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ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury by Beattie, Michael S, Harrington, Anthony W, Lee, Ramee, Kim, Ju Young, Boyce, Sheri L, Longo, Frank M, Bresnahan, Jacqueline C, Hempstead, Barbara L, Yoon, Sung Ok

“…The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its role after injury has remained unclear. Here, we report that p75 is…”
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Long-distance retrograde neurotrophic factor signalling in neurons by Harrington, Anthony W., Ginty, David D.

“…Key Points Neurons require specialized mechanisms of intracellular neurotrophic factor signalling for communication over the long distances between axon…”
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The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule Neurons by Harrington, Anthony W., Li, Qi Ming, Tep, Chhavy, Park, Jong Bae, He, Zhigang, Yoon, Sung Ok

“…p75 and the Nogo receptor form a signaling unit for myelin inhibitory molecules, with p75 being responsible for RhoA activation. Because p75 lacks the GDP/GTP…”
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Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival by Suo, Dong, Park, Juyeon, Harrington, Anthony W, Zweifel, Larry S, Mihalas, Stefan, Deppmann, Christopher D

“…In this study, the authors report that target-derived NGF signaling induces the expression of Coronin-1, which consequently gets recruited to the…”
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Identification and characterization of select oxysterols as ligands for GPR17 by Harrington, Anthony W., Liu, Changlu, Phillips, Naomi, Nepomuceno, Diane, Kuei, Chester, Chang, Joseph, Chen, Weixuan, Sutton, Steven W., O'Malley, Daniel, Pham, Ly, Yao, Xiang, Sun, Siquan, Bonaventure, Pascal

“…Background and Purpose G‐protein coupled receptor 17 (GPR17) is an orphan receptor involved in the process of myelination, due to its ability to inhibit the…”
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Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis by Harrington, Anthony W, Kim, Ju Young, Yoon, Sung Ok

“…The neurotrophin receptor p75 can induce apoptosis both in vitro and in vivo. The mechanisms by which p75 induces apoptosis have remained mostly unknown. Here,…”
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Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival by Suo, Dong, Park, Juyeon, Harrington, Anthony W., Zweifel, Larry S., Mihalas, Stefan, Deppmann, Christopher D.

“…Retrograde communication from axonal targets to neuronal cell bodies is critical for both development and function of the nervous system. Much progress has…”
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Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death by Massa, Stephen M, Xie, Youmei, Yang, Tao, Harrington, Anthony W, Kim, Mi Lyang, Yoon, Sung Ok, Kraemer, Rosemary, Moore, Laura A, Hempstead, Barbara L, Longo, Frank M

“…Studies showing that neurotrophin binding to p75NTR can promote cell survival in the absence of Trk (tropomyosin-related kinase) receptors, together with…”
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Brain [alpha]7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO by Gu, Shenyan, Matta, Jose A, Lord, Brian, Harrington, Anthony W, Sutton, Steven W, Davini, Weston B, Bredt, David S

“…Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling…”
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The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule NeuronsS by Harrington, Anthony W., Li, Qi Ming, Tep, Chhavy, Park, Jong Bae, He, Zhigang, Yoon, Sung Ok

“…p75 and the Nogo receptor form a signaling unit for myelin inhibitory molecules, with p75 being responsible for RhoA activation. Because p75 lacks the GDP/GTP…”
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Small, Nonpeptide p75 NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death by Massa, Stephen M., Xie, Youmei, Yang, Tao, Harrington, Anthony W., Kim, Mi Lyang, Yoon, Sung Ok, Kraemer, Rosemary, Moore, Laura A., Hempstead, Barbara L., Longo, Frank M.

“…Studies showing that neurotrophin binding to p75 NTR can promote cell survival in the absence of Trk (tropomyosin-related kinase) receptors, together with…”
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Small, Nonpeptide p75 super(NTR) Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death by Massa, Stephen M, Xie, Youmei, Yang, Tao, Harrington, Anthony W, Kim, Mi Lyang, Yoon, Sung Ok, Kraemer, Rosemary, Moore, Laura A, Hempstead, Barbara L, Longo, Frank M

“…Studies showing that neurotrophin binding to p75 super(NTR) can promote cell survival in the absence of Trk (tropomyosin-related kinase) receptors, together…”
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Mechanism and consequence of p75 signalling by Harrington, Anthony W

“…The neurotrophin receptor p75 is responsible for a wide variety of signaling essential for proper development of the nervous system including cell survival and…”
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