Search Results - "Harrigan, Patrick"

Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control by Harrigan, Patrick, Madhani, Hiten D., El-Samad, Hana

“…Biological signaling networks use feedback control to dynamically adjust their operation in real time. Traditional static genetic methods such as gene…”
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The evolution of gene expression levels in mammalian organs by Brawand, David, Soumillon, Magali, Necsulea, Anamaria, Julien, Philippe, Csárdi, Gábor, Harrigan, Patrick, Weier, Manuela, Liechti, Angélica, Aximu-Petri, Ayinuer, Kircher, Martin, Albert, Frank W., Zeller, Ulrich, Khaitovich, Philipp, Grützner, Frank, Bergmann, Sven, Nielsen, Rasmus, Pääbo, Svante, Kaessmann, Henrik

“…Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression…”
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Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast by Aranda-Díaz, Andrés, Mace, Kieran, Zuleta, Ignacio, Harrigan, Patrick, El-Samad, Hana

“…Cellular phenotypes are the result of complex interactions between many components. Understanding and predicting the system level properties of the resulting…”
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Feasibility of virtual low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson’s disease by Elshourbagy, Abdelwahab, Eltaras, Mennatullah Mohamed, Abdalshafy, Hassan, Javed, Samrah, Sadaney, Ahmed Omar, Harrigan, Timothy Patrick, Mills, Kelly Alexander, Hernandez, Manuel Enrique, Brašić, James Robert

“…A low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson‘s disease, a structured motor assessment administered…”
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Corrigendum to “Feasibility of virtual low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson's disease” [MethodsX 11 (2023) 102230] by Elshourbagy, Abdelwahab, Eltaras, Mennatullah Mohamed, Abdalshafy, Hassan, Javed, Samrah, Sadaney, Ahmed Omar, Harrigan, Timothy Patrick, Mills, Kelly Alexander, Hernandez, Manuel Enrique, Brašić, James Robert

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Dataset of quality assurance measurements of rhythmic movements by Ziegelman, Liran, Kosuri, Tanvi, Hakim, Husain, Zhao, Luqi, Elshourbagy, Abdelwahab, Mills, Kelly Alexander, Harrigan, Timothy Patrick, Hernandez, Manuel Enrique, Brašić, James Robert

“…A low-cost quantitative structured office measurement of movements in the extremities of people with Parkinson's disease [1,2] was performed on participants…”
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Modeling gene expression evolution with an extended Ornstein-Uhlenbeck process accounting for within-species variation by Rohlfs, Rori V, Harrigan, Patrick, Nielsen, Rasmus

“…Much of the phenotypic variation observed between even closely related species may be driven by differences in gene expression levels. The current availability…”
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France. UrbanaHuppert, George, Public Schools in Renaissance and Chicago: University of Illinois Press, 1984 by Harrigan, Patrick J.

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Single-cell analysis of habituation in Stentor coeruleus by Rajan, Deepa, Makushok, Tatyana, Kalish, Asa, Acuna, Lilibeth, Bonville, Alex, Correa Almanza, Kathya, Garibay, Brenda, Tang, Eric, Voss, Megan, Lin, Athena, Barlow, Kyle, Harrigan, Patrick, Slabodnick, Mark M., Marshall, Wallace F.

“…Although learning is often viewed as a unique feature of organisms with complex nervous systems, single-celled organisms also demonstrate basic forms of…”
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Women's agency and the development of women's intercollegiate athletics, 1961 - 2001 by Harrigan, Patrick J

“…Autonomous women’s athletics had a strong foundation, especially in central Canada, from the 1920s. The expansion of women’s programs from the 1960s on was due…”
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You get what you screen for: on the value of fermentation characterization in high-throughput strain improvements in industrial settings by Wehrs, Maren, de Beaumont-Felt, Alexander, Goranov, Alexi, Harrigan, Patrick, de Kok, Stefan, Lieder, Sarah, Vallandingham, Jim, Tyner, Kristina

“…While design and high-throughput build approaches in biotechnology have increasingly gained attention over the past decade, approaches to test strain…”
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Church, State, and Education in France From the Falloux to the Ferry Laws: A Reassessment by Harrigan, Patrick J

“…Contrary to the traditional interpretation of republican historiography, the Falloux Law opened a unique period of cooperation between Church and State in…”
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Building robust functionality in synthetic circuits using engineered feedback regulation by Chen, Susan, Harrigan, Patrick, Heineike, Benjamin, Stewart-Ornstein, Jacob, El-Samad, Hana

“…Graphical abstract Highlights ► Engineered feedback loops implement elaborate functionality in synthetic circuits. ► The homeostatic potential of feedback…”
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Combining Classical Genetics with Control Theory to Study Feedback Regulation in Signaling Networks by Harrigan, Patrick

“…The ability to self-regulate in feedback is what allows cells to operate robustly despite the uncertainties of both a changing external environment and their…”
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A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells by Fonseca, João Pedro, Bonny, Alain R, Kumar, G. Renuka, Ng, Andrew H, Town, Jason, Wu, Qiu Chang, Aslankoohi, Elham, Chen, Susan Y, Dods, Galen, Harrigan, Patrick, Osimiri, Lindsey C, Kistler, Amy L, El-Samad, Hana

“…The ability to rapidly assemble and prototype cellular circuits is vital for biological research and its applications in biotechnology and medicine. Current…”
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From the Salon to the Schoolroom: Educating Bourgeois Girls in Nineteenth-Century France by Harrigan, Patrick

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The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial by Burns, Daniel K., Chiang, Carl, Welsh-Bohmer, Kathleen A., Brannan, Stephen K., Culp, Meredith, O'Neil, Janet, Runyan, Grant, Harrigan, Patrick, Plassman, Brenda L., Lutz, Michael, Lai, Eric, Haneline, Stephen, Yarnall, David, Yarbrough, Deborah, Metz, Craig, Ponduru, Sridevi, Sundseth, Scott, Saunders, Ann M., Dubois, Bruno, Cummings, Jeffrey, Doody, Rachelle, Lyketsos, Constantine, Reiman, Eric, Welsh-Bohmer, Kathleen A., Welsh-Bohmer, Kathleen A., Sano, Mary, Schneider, Lon, Craft, Suzanne, Espeland, Mark, Monsch, Andreas

“…Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more…”
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P1‐050: ADJUDICATING MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE AS A NOVEL ENDPOINT EVENT IN THE TOMMORROW STUDY: A DELAY‐OF‐ONSET PHASE 3 CLINICAL TRIAL by Chiang, Carl, Alexander, Robert, Welsh-Bohmer, Kathleen A., Plassman, Brenda L., Romero, Heather, Hayden, Kathleen M., Keefe, Richard SE, Atkins, Alexandra S., Harrigan, Patrick, O'Neil, Janet, Culp, Meredith, Walter, Ryan, Wu, Jingtao, Randle, LaDonna, Haneline, Stephen, Yarbrough, Deborah, Metz, Craig, Burns, Daniel K., Saunders, Ann M.

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ADJUDICATING MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER’S DISEASE AS A NOVEL ENDPOINT EVENT IN THE TOMMORROW STUDY: A DELAY-OF-ONSET PHASE 3 CLINICAL TRIAL by Chiang, Carl, Alexander, Robert, Welsh-Bohmer, Kathleen A., Plassman, Brenda L., Romero, Heather, Hayden, Kathleen M., Keefe, Richard SE, Atkins, Alexandra S., Harrigan, Patrick, O'Neil, Janet, Culp, Meredith, Walter, Ryan, Wu, Jingtao, Randle, LaDonna, Haneline, Stephen, Yarbrough, Deborah, Metz, Craig, Burns, Daniel K., Saunders, Ann M.

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P4‐383: Characterization of the Screened Population for the Tommorrow Study: a Pharmacogenetics‐Supported Clinical Trial to Delay the Onset of Mild Cognitive Impairment Due to Alzheimer’S Disease by Martenyi, Ferenc, Welsh-Bohmer, Kathleen A., Plassman, Brenda L., Harrigan, Patrick, Chiang, Carl, O'Neil, Janet, Runyan, Grant, Culp, Meredith, Lutz, Michael W., Lai, Eric, Saunders, Ann M., Haneline, Stephen, Yarnall, David, Yarbrough, Deborah, Metz, Craig, Burns, Daniel K., Roses, Allen D.

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