Search Results - "Harriff, Melanie J."

MAIT cells and microbial immunity by Meermeier, Erin W, Harriff, Melanie J, Karamooz, Elham, Lewinsohn, David M

“…Mucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial…”
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Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens by Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K., Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C., Lewinsohn, David M.

“…Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a…”
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Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells by Harriff, Melanie J, Karamooz, Elham, Burr, Ansen, Grant, Wilmon F, Canfield, Elizabeth T, Sorensen, Michelle L, Moita, Luis F, Lewinsohn, David M

“…Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play…”
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Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells by Harriff, Melanie J, Cansler, Meghan E, Toren, Katelynne Gardner, Canfield, Elizabeth T, Kwak, Stephen, Gold, Marielle C, Lewinsohn, David M

“…Mycobacterium tuberculosis (Mtb) is transmitted via inhalation of aerosolized particles. While alveolar macrophages are thought to play a central role in the…”
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Human mucosal associated invariant T cells detect bacterially infected cells by Gold, Marielle C, Cerri, Stefania, Smyk-Pearson, Susan, Cansler, Meghan E, Vogt, Todd M, Delepine, Jacob, Winata, Ervina, Swarbrick, Gwendolyn M, Chua, Wei-Jen, Yu, Yik Y L, Lantz, Olivier, Cook, Matthew S, Null, Megan D, Jacoby, David B, Harriff, Melanie J, Lewinsohn, Deborah A, Hansen, Ted H, Lewinsohn, David M

“…Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive…”
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The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence by Wright, Catherine C, Hsu, Fong Fu, Arnett, Eusondia, Dunaj, Jennifer L, Davidson, Patrick M, Pacheco, Sophia A, Harriff, Melanie J, Lewinsohn, David M, Schlesinger, Larry S, Purdy, Georgiana E

“…The mycobacterial cell wall is crucial to the host-pathogen interface, because it provides a barrier against antibiotics and the host immune response. In…”
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T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells by McMurtrey, Curtis, Harriff, Melanie J, Swarbrick, Gwendolyn M, Duncan, Amanda, Cansler, Meghan, Null, Megan, Bardet, Wilfried, Jackson, Kenneth W, Lewinsohn, Deborah A, Hildebrand, William, Lewinsohn, David M

“…HLA-E is a non-conventional MHC Class I molecule that has been recently demonstrated to present pathogen-derived ligands, resulting in the TCR-dependent…”
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Construction and validation of an ultraviolet germicidal irradiation system using locally available components by Schnell, Eric, Karamooz, Elham, Harriff, Melanie J, Yates, Jane E, Pfeiffer, Christopher D, Smith, Stephen M

“…Coronavirus disease (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is responsible for a global…”
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Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells by Jin, Haihong, Ladd, Nicole A., Peev, Andrew M., Swarbrick, Gwendolyn M., Cansler, Meghan, Null, Megan, Boughter, Christopher T., McMurtrey, Curtis, Nilsen, Aaron, Dobos, Karen M., Hildebrand, William H., Lewinsohn, Deborah A., Adams, Erin J., Lewinsohn, David M., Harriff, Melanie J.

“…MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early…”
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HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells by Harriff, Melanie J., Wolfe, Lisa M., Swarbrick, Gwendolyn, Null, Megan, Cansler, Meghan E., Canfield, Elizabeth T., Vogt, Todd, Toren, Katelynne Gardner, Li, Wei, Jackson, Mary, Lewinsohn, Deborah A., Dobos, Karen M., Lewinsohn, David M.

“…Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically…”
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Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates by van der Geest, Rick, Fan, Hongye, Peñaloza, Hernán F, Bain, William G, Xiong, Zeyu, Kohli, Naina, Larson, Emily, Sullivan, Mara L G, Franks, Jonathan M, Stolz, Donna B, Ito, Ryota, Chen, Kong, Doi, Yohei, Harriff, Melanie J, Lee, Janet S

“…( ) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of…”
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The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle by Grotzke, Jeff E, Harriff, Melanie J, Siler, Anne C, Nolt, Dawn, Delepine, Jacob, Lewinsohn, Deborah A, Lewinsohn, David M

“…Mycobacterium tuberculosis (Mtb) resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and…”
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TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I by Harriff, Melanie J, Burgdorf, Sven, Kurts, Christian, Wiertz, Emmanuel J H J, Lewinsohn, Deborah A, Lewinsohn, David M

“…Processing and presentation of antigen on MHC-I class I molecules serves to present peptides derived from cytosolic proteins to CD8(+) T cells. Infection with…”
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Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation by Kulicke, Corinna A., Swarbrick, Gwendolyn M., Ladd, Nicole A., Cansler, Meghan, Null, Megan, Worley, Aneta, Lemon, Chance, Ahmed, Tania, Bennett, Joshua, Lust, Taylor N., Heisler, Chelsea M., Huber, Megan E., Krawic, Jason R., Ankley, Laurisa M., McBride, Savannah K., Tafesse, Fikadu G., Olive, Andrew J., Hildebrand, William H., Lewinsohn, Deborah A., Adams, Erin J., Lewinsohn, David M., Harriff, Melanie J.

“…MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation…”
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Ex Vivo Lung Perfusion Provides New Insights into Human Lung-Resident Immune Cell Localization and Functional Interactions by Soma, Shogo, Harriff, Melanie J

“…Soma and Harriff discuss the study by Snyder and colleagues which support the innovative use of Ex Vivo Lung Perfusion (EVLP) for the study of complex human…”
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MR1-dependent antigen presentation by Karamooz, Elham, Harriff, Melanie J., Lewinsohn, David M.

“…MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for…”
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Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated Mucosal-associated Invariant T-Cell Activation by Huber, Megan E, Larson, Emily, Lust, Taylor N, Heisler, Chelsea M, Harriff, Melanie J

“…Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8 T lymphocytes, and infection-driven…”
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Species of Environmental Mycobacteria Differ in Their Abilities To Grow in Human, Mouse, and Carp Macrophages and with Regard to the Presence of Mycobacterial Virulence Genes, as Observed by DNA Microarray Hybridization by Harriff, Melanie J, Wu, Martin, Kent, Michael L, Bermudez, Luiz E

“…There are many species of environmental mycobacteria (EM) that infect animals that are important to the economy and research and that also have zoonotic…”
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Mycobacterium avium Genes MAV_5138 and MAV_3679 Are Transcriptional Regulators That Play a Role in Invasion of Epithelial Cells, in Part by Their Regulation of CipA, a Putative Surface Protein Interacting with Host Cell Signaling Pathways by HARRIFF, Melanie J, DANELISHVILI, Lia, WU, Martin, WILDER, Cara, MCNAMARA, Michael, KENT, Michael L, BERMUDEZ, Luiz E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens by Karamooz, Elham, Harriff, Melanie J., Narayanan, Gitanjali A., Worley, Aneta, Lewinsohn, David M.

“…The MHC-Ib molecule MR1 presents microbial metabolites to MR1-restricted T cells (MR1Ts). Given the ubiquitous expression of MR1 and the high prevalence of…”
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