Search Results - "Harries, W"

Long non-coding RNAs and human disease by Harries, Lorna W

“…The central dogma of molecular biology states that DNA is transcribed into RNA, which in turn is translated into proteins. We now know, however, that as much…”
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Splicing regulatory factors, ageing and age-related disease by Latorre, Eva, Harries, Lorna. W

“…Highlights • Alternative splicing (AS) is emerging as an important control point of gene expression. • AS allows a single gene to produce several mRNA with…”
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RNA Biology Provides New Therapeutic Targets for Human Disease by Harries, Lorna W

“…RNA is the messenger molecule that conveys information from the genome and allows the production of biomolecules required for life in a responsive and…”
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease by Lunnon, Katie, Smith, Rebecca, Hannon, Eilis, De Jager, Philip L, Srivastava, Gyan, Volta, Manuela, Troakes, Claire, Al-Sarraj, Safa, Burrage, Joe, Macdonald, Ruby, Condliffe, Daniel, Harries, Lorna W, Katsel, Pavel, Haroutunian, Vahram, Kaminsky, Zachary, Joachim, Catharine, Powell, John, Lovestone, Simon, Bennett, David A, Schalkwyk, Leonard C, Mill, Jonathan

“…Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive neuropathology and cognitive decline. Here the authors describe…”
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Human longevity: 25 genetic loci associated in 389,166 UK biobank participants by Pilling, Luke C, Kuo, Chia-Ling, Sicinski, Kamil, Tamosauskaite, Jone, Kuchel, George A, Harries, Lorna W, Herd, Pamela, Wallace, Robert, Ferrucci, Luigi, Melzer, David

“…We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers'…”
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Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans by Fletcher, Tony, Galloway, Tamara S., Melzer, David, Holcroft, Paul, Cipelli, Riccardo, Pilling, Luke C., Mondal, Debapriya, Luster, Michael, Harries, Lorna W.

“…Perfluorooctanoic acid (PFOA, ‘C8’) and perfluoroctane sulphonate (PFOS) are environmentally stable compounds with industrial and consumer uses and long…”
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An evaluation of the role of miR-361-5p in senescence and systemic ageing by Manni, Emad, Jeffery, Nicola, Chambers, David, Slade, Luke, Etheridge, Timothy, Harries, Lorna W.

“…Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular…”
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Human genetic variation and its effect on miRNA biogenesis, activity and function by Hogg, Daniel R, Harries, Lorna W

“…miRNAs are small non-coding regulators of gene expression that are estimated to regulate over 60% of all human genes. Each miRNA can target multiple mRNA…”
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Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer by Mou, Zhuofan, Spencer, Jack, McGrath, John S, Harries, Lorna W

“…Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a hallmark of cancer that profoundly influences the development and…”
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To help aging populations, classify organismal senescence by Calimport, Stuart R G, Bentley, Barry L, Stewart, Claire E, Pawelec, Graham, Scuteri, Angelo, Vinciguerra, Manlio, Slack, Cathy, Chen, Danica, Harries, Lorna W, Marchant, Gary, Fleming, G Alexander, Conboy, Michael, Antebi, Adam, Small, Gary W, Gil, Jesus, Lakatta, Edward G, Richardson, Arlan, Rosen, Clifford, Nikolich, Karoly, Wyss-Coray, Tony, Steinman, Lawrence, Montine, Thomas, de Magalhães, João Pedro, Campisi, Judith, Church, George

“…Comprehensive disease classification and staging is required to address unmet needs of aging populations Globally, citizens exist for sustained periods in…”
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Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood by Haque, Shahnaz, Ames, Ryan M, Moore, Karen, Lee, Benjamin P, Jeffery, Nicola, Harries, Lorna W

“…Circular RNAs are non-coding RNA molecules with gene regulatory potential that have been associated with several human diseases. They are stable and present in…”
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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing by Harries, Lorna W., Hernandez, Dena, Henley, William, Wood, Andrew R., Holly, Alice C., Bradley‐Smith, Rachel M., Yaghootkar, Hanieh, Dutta, Ambarish, Murray, Anna, Frayling, Timothy M., Guralnik, Jack M., Bandinelli, Stefania, Singleton, Andrew, Ferrucci, Luigi, Melzer, David

“…Summary Aging is a major risk factor for chronic disease in the human population, but there are little human data on gene expression alterations that accompany…”
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Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion by Locke, J. M., da Silva Xavier, G., Dawe, H. R., Rutter, G. A., Harries, L. W.

“…Aims/hypothesis Type 2 diabetes is characterised by progressive beta cell dysfunction, with changes in gene expression playing a crucial role in its…”
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers by Pilling, Luke C, Atkins, Janice L, Duff, Michael O, Beaumont, Robin N, Jones, Samuel E, Tyrrell, Jessica, Kuo, Chia-Ling, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Wood, Andrew R, Murray, Anna, Weedon, Michael N, Harries, Lorna W, Kuchel, George A, Ferrucci, Luigi, Frayling, Timothy M, Melzer, David

“…Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and…”
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Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals by Davies, Merlin, Bramwell, Laura R, Jeffery, Nicola, Bunce, Ben, Lee, Ben P, Knight, Bridget, Auckland, Cressida, Masoli, Jane AH, Harries, Lorna W

“…•SARS-CoV-2 activity is difficult to assess with conventional PCR assays.•Subgenomic RNA (sgRNA) may be a better proxy for infectivity.•Over 10% of COVID-19…”
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Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer by Munkley, Jennifer, Li, Ling, Krishnan, S R Gokul, Hysenaj, Gerald, Scott, Emma, Dalgliesh, Caroline, Oo, Htoo Zarni, Maia, Teresa Mendes, Cheung, Kathleen, Ehrmann, Ingrid, Livermore, Karen E, Zielinska, Hanna, Thompson, Oliver, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Harries, Lorna W, Daugaard, Mads, Cockell, Simon, Barbosa-Morais, Nuno L, Oltean, Sebastian, Elliott, David J

“…Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy…”
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Gene expression analysis reveals a 5-gene signature for progression-free survival in prostate cancer by Mou, Zhuofan, Spencer, Jack, Knight, Bridget, John, Joseph, McCullagh, Paul, McGrath, John S., Harries, Lorna W.

“…Prostate cancer (PCa) is the second most common male cancer worldwide, but effective biomarkers for the presence or progression risk of disease are currently…”
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Obesity impacts the regulation of miR-10b and its targets in primary breast tumors by Meerson, Ari, Eliraz, Yaniv, Yehuda, Hila, Knight, Bridget, Crundwell, Malcolm, Ferguson, Douglas, Lee, Benjamin P, Harries, Lorna W

“…Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms which may partly be regulated by microRNAs (miRNAs)…”
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Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies by Locke, Jonathan M, Hysenaj, Gerald, Wood, Andrew R, Weedon, Michael N, Harries, Lorna W

“…Genome-wide association studies (GWAS) have identified variation at >65 genomic loci associated with susceptibility to type 2 diabetes, but little progress has…”
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Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones by Bramwell, Laura R, Frankum, Ryan, Harries, Lorna W

“…Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug…”
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